Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| peripheral blood | 17 studies | 38% ± 12% | |
| lung | 13 studies | 30% ± 12% | |
| intestine | 7 studies | 25% ± 6% | |
| kidney | 6 studies | 38% ± 16% | |
| uterus | 5 studies | 24% ± 5% | |
| lymph node | 5 studies | 29% ± 11% | |
| liver | 3 studies | 38% ± 14% | |
| breast | 3 studies | 28% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| kidney | 100% | 5120.43 | 89 / 89 | 98% | 237.55 | 880 / 901 |
| breast | 96% | 1711.93 | 442 / 459 | 91% | 352.11 | 1016 / 1118 |
| prostate | 100% | 1805.98 | 245 / 245 | 87% | 144.69 | 437 / 502 |
| ovary | 100% | 1605.06 | 180 / 180 | 86% | 191.79 | 370 / 430 |
| thymus | 100% | 1498.03 | 651 / 653 | 84% | 114.23 | 511 / 605 |
| lung | 100% | 3471.83 | 578 / 578 | 79% | 157.48 | 917 / 1155 |
| liver | 100% | 1723.73 | 225 / 226 | 75% | 92.56 | 303 / 406 |
| uterus | 99% | 985.84 | 168 / 170 | 75% | 141.13 | 342 / 459 |
| stomach | 99% | 1158.92 | 356 / 359 | 70% | 132.25 | 199 / 286 |
| brain | 83% | 783.56 | 2185 / 2642 | 84% | 116.78 | 595 / 705 |
| intestine | 100% | 1737.75 | 963 / 966 | 63% | 111.46 | 334 / 527 |
| bladder | 100% | 822.00 | 21 / 21 | 61% | 132.07 | 307 / 504 |
| esophagus | 92% | 822.52 | 1324 / 1445 | 56% | 76.02 | 103 / 183 |
| pancreas | 32% | 179.88 | 106 / 328 | 87% | 187.09 | 154 / 178 |
| adrenal gland | 88% | 543.90 | 227 / 258 | 14% | 11.99 | 33 / 230 |
| spleen | 100% | 2207.00 | 241 / 241 | 0% | 0 | 0 / 0 |
| skin | 41% | 167.36 | 742 / 1809 | 55% | 87.07 | 260 / 472 |
| peripheral blood | 95% | 1533.89 | 887 / 929 | 0% | 0 | 0 / 0 |
| adipose | 95% | 1007.83 | 1143 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 93% | 214.87 | 27 / 29 |
| blood vessel | 87% | 560.54 | 1165 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 82% | 104.86 | 37 / 45 |
| heart | 65% | 292.19 | 557 / 861 | 0% | 0 | 0 / 0 |
| muscle | 38% | 157.43 | 309 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 26% | 54.22 | 21 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006644 | Biological process | phospholipid metabolic process |
| GO_0070292 | Biological process | N-acylphosphatidylethanolamine metabolic process |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0150074 | Biological process | positive regulation of protein-glutamine gamma-glutamyltransferase activity |
| GO_0045618 | Biological process | positive regulation of keratinocyte differentiation |
| GO_0036152 | Biological process | phosphatidylethanolamine acyl-chain remodeling |
| GO_0016042 | Biological process | lipid catabolic process |
| GO_0005829 | Cellular component | cytosol |
| GO_0016020 | Cellular component | membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0004623 | Molecular function | phospholipase A2 activity |
| GO_0016410 | Molecular function | N-acyltransferase activity |
| GO_0008970 | Molecular function | phospholipase A1 activity |
| GO_0016746 | Molecular function | acyltransferase activity |
| GO_0052739 | Molecular function | phosphatidylserine 1-acylhydrolase activity |
| GO_0052740 | Molecular function | 1-acyl-2-lysophosphatidylserine acylhydrolase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | PLAAT4 |
| Protein name | Phospholipase A and acyltransferase 4 (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (HRAS-like suppressor 4) (HRSL4) (RAR-responsive protein TIG3) (Retinoic acid receptor responder protein 3) (Retinoid-inducible gene 1 protein) (Tazarotene-induced gene 3 protein) Retinoic acid receptor responder protein 3 Phospholipase A and acyltransferase 4 |
| Synonyms | TIG3 RARRES3 RIG1 |
| Description | FUNCTION: Exhibits both phospholipase A1/2 and acyltransferase activities . Shows phospholipase A1 (PLA1) and A2 (PLA2), catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids . For most substrates, PLA1 activity is much higher than PLA2 activity . Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid . Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) . Promotes keratinocyte differentiation via activation of TGM1 . . |
| Accessions | A0A348GSI2 Q9UL19 ENST00000255688.8 [Q9UL19-1] ENST00000439013.6 [Q9UL19-2] A6NG31 ENST00000354445.2 |