PHF3 report

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I. Expression across cell types

Cell ontologyData table

Name	Number of supported studies	Average coverage
B cell	30 studies	26% ± 9%	Explore
natural killer cell	27 studies	24% ± 8%	Explore
endothelial cell	27 studies	30% ± 12%	Explore
macrophage	21 studies	25% ± 11%	Explore
fibroblast	21 studies	28% ± 11%	Explore
CD4-positive, alpha-beta T cell	21 studies	26% ± 8%	Explore
CD8-positive, alpha-beta T cell	19 studies	26% ± 7%	Explore
regulatory T cell	19 studies	26% ± 8%	Explore
memory B cell	18 studies	25% ± 7%	Explore
T cell	17 studies	26% ± 9%	Explore
naive B cell	17 studies	28% ± 8%	Explore
mast cell	15 studies	24% ± 6%	Explore
pericyte	15 studies	23% ± 8%	Explore
ciliated cell	15 studies	27% ± 10%	Explore
gamma-delta T cell	15 studies	28% ± 10%	Explore
classical monocyte	14 studies	22% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	29% ± 10%	Explore
non-classical monocyte	14 studies	25% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	26% ± 7%	Explore
smooth muscle cell	13 studies	23% ± 5%	Explore
basal cell	13 studies	31% ± 14%	Explore
astrocyte	13 studies	36% ± 17%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	25% ± 8%	Explore
mucosal invariant T cell	13 studies	27% ± 7%	Explore
plasmacytoid dendritic cell	12 studies	27% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	30% ± 10%	Explore
oligodendrocyte	12 studies	40% ± 15%	Explore
oligodendrocyte precursor cell	12 studies	32% ± 16%	Explore
mature NK T cell	12 studies	24% ± 6%	Explore
microglial cell	12 studies	34% ± 13%	Explore
endothelial cell of lymphatic vessel	11 studies	28% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	29% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	28% ± 8%	Explore
epithelial cell	11 studies	38% ± 17%	Explore
monocyte	10 studies	23% ± 8%	Explore
glutamatergic neuron	10 studies	43% ± 24%	Explore
type I pneumocyte	9 studies	29% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	27% ± 8%	Explore
type II pneumocyte	8 studies	27% ± 9%	Explore
GABAergic neuron	8 studies	46% ± 20%	Explore
myofibroblast cell	8 studies	23% ± 7%	Explore
adipocyte	8 studies	37% ± 11%	Explore
conventional dendritic cell	7 studies	24% ± 9%	Explore
neuron	7 studies	36% ± 22%	Explore
interneuron	7 studies	44% ± 25%	Explore
club cell	7 studies	31% ± 9%	Explore
amacrine cell	7 studies	29% ± 12%	Explore
retinal rod cell	7 studies	24% ± 8%	Explore
dendritic cell	7 studies	31% ± 14%	Explore
plasma cell	6 studies	27% ± 8%	Explore
respiratory goblet cell	6 studies	28% ± 8%	Explore
secretory cell	6 studies	25% ± 6%	Explore
leukocyte	6 studies	28% ± 6%	Explore
connective tissue cell	6 studies	24% ± 6%	Explore
plasmablast	5 studies	30% ± 11%	Explore
capillary endothelial cell	5 studies	19% ± 2%	Explore
retinal bipolar neuron	5 studies	21% ± 6%	Explore
precursor B cell	5 studies	28% ± 8%	Explore
myeloid cell	5 studies	26% ± 6%	Explore
lymphocyte	5 studies	30% ± 11%	Explore
Mueller cell	5 studies	27% ± 11%	Explore
T follicular helper cell	5 studies	27% ± 9%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	30% ± 9%	Explore
hematopoietic precursor cell	4 studies	33% ± 16%	Explore
abnormal cell	4 studies	34% ± 17%	Explore
glial cell	4 studies	23% ± 5%	Explore
granule cell	4 studies	31% ± 5%	Explore
pro-B cell	4 studies	29% ± 4%	Explore
immature B cell	4 studies	26% ± 7%	Explore
retina horizontal cell	4 studies	30% ± 12%	Explore
retinal cone cell	4 studies	27% ± 11%	Explore
endothelial cell of vascular tree	4 studies	29% ± 11%	Explore
innate lymphoid cell	4 studies	24% ± 5%	Explore
hepatocyte	4 studies	48% ± 15%	Explore
hematopoietic stem cell	4 studies	30% ± 5%	Explore
goblet cell	4 studies	35% ± 23%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	21% ± 5%	Explore
kidney loop of Henle epithelial cell	4 studies	20% ± 3%	Explore
ionocyte	3 studies	37% ± 8%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	29% ± 4%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	25% ± 4%	Explore
exhausted T cell	3 studies	27% ± 11%	Explore
glomerular endothelial cell	3 studies	17% ± 0%	Explore
GABAergic interneuron	3 studies	35% ± 3%	Explore
progenitor cell	3 studies	34% ± 2%	Explore
retinal ganglion cell	3 studies	27% ± 11%	Explore
brush cell	3 studies	27% ± 9%	Explore
endothelial cell of artery	3 studies	16% ± 1%	Explore
vein endothelial cell	3 studies	29% ± 17%	Explore
GABAergic amacrine cell	3 studies	29% ± 14%	Explore
OFF-bipolar cell	3 studies	31% ± 9%	Explore
ON-bipolar cell	3 studies	33% ± 10%	Explore
glycinergic amacrine cell	3 studies	30% ± 10%	Explore
rod bipolar cell	3 studies	33% ± 13%	Explore
erythroblast	3 studies	22% ± 7%	Explore
CD4-positive helper T cell	3 studies	26% ± 7%	Explore
neural progenitor cell	3 studies	34% ± 5%	Explore
ependymal cell	3 studies	34% ± 15%	Explore
granulocyte	3 studies	27% ± 9%	Explore
intestinal crypt stem cell	3 studies	21% ± 3%	Explore
alveolar macrophage	3 studies	28% ± 9%	Explore
group 3 innate lymphoid cell	3 studies	32% ± 12%	Explore
transit amplifying cell	3 studies	33% ± 22%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	31% ± 3%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	26% ± 5%	Explore
double negative thymocyte	3 studies	41% ± 10%	Explore
erythrocyte	3 studies	29% ± 14%	Explore

II. Expression across tissues

sc-RNAseq dataData table

Name	Number of supported studies	Average coverage
brain	16 studies	37% ± 21%	Explore
peripheral blood	15 studies	27% ± 7%	Explore
lung	11 studies	24% ± 7%	Explore
eye	8 studies	29% ± 14%	Explore
kidney	6 studies	22% ± 4%	Explore
bone marrow	4 studies	23% ± 6%	Explore
liver	4 studies	35% ± 15%	Explore
adipose	4 studies	28% ± 6%	Explore
heart	3 studies	19% ± 3%	Explore
uterus	3 studies	31% ± 11%	Explore
lymph node	3 studies	21% ± 4%	Explore
intestine	3 studies	25% ± 6%	Explore

Bulk RNAseq dataData table

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4208.83	1445 / 1445	100%	15.91	183 / 183
lung	100%	5258.44	578 / 578	99%	13.53	1149 / 1155
breast	100%	6878.09	459 / 459	99%	19.60	1110 / 1118
thymus	100%	6509.16	653 / 653	99%	18.39	600 / 605
prostate	100%	5600.90	245 / 245	99%	15.34	496 / 502
brain	100%	3267.98	2634 / 2642	99%	13.76	698 / 705
pancreas	100%	2904.87	328 / 328	98%	11.65	175 / 178
ovary	100%	8663.32	180 / 180	98%	9.36	421 / 430
stomach	100%	3643.75	359 / 359	97%	13.16	278 / 286
intestine	100%	5351.23	966 / 966	97%	11.98	511 / 527
uterus	100%	7445.69	170 / 170	97%	11.02	444 / 459
bladder	100%	5462.57	21 / 21	96%	10.39	485 / 504
adrenal gland	100%	5216.51	258 / 258	94%	9.56	217 / 230
kidney	100%	3565.34	89 / 89	94%	13.00	845 / 901
skin	100%	5613.00	1809 / 1809	92%	12.18	432 / 472
liver	100%	2722.48	226 / 226	91%	8.86	369 / 406
blood vessel	100%	5582.81	1335 / 1335	0%	0	0 / 0
spleen	100%	4245.81	241 / 241	0%	0	0 / 0
adipose	100%	6362.37	1203 / 1204	0%	0	0 / 0
muscle	100%	4121.48	801 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	11.67	43 / 45
heart	95%	2736.21	817 / 861	0%	0	0 / 0
peripheral blood	94%	3607.38	872 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	90%	9.11	26 / 29
eye	0%	0	0 / 0	61%	4.68	49 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1