PDE4D | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	28 studies	56% ± 22%	Explore
natural killer cell	21 studies	26% ± 8%	Explore
astrocyte	18 studies	65% ± 21%	Explore
T cell	17 studies	28% ± 15%	Explore
fibroblast	16 studies	50% ± 20%	Explore
oligodendrocyte precursor cell	14 studies	69% ± 22%	Explore
CD4-positive, alpha-beta T cell	14 studies	21% ± 5%	Explore
oligodendrocyte	13 studies	55% ± 18%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	31% ± 10%	Explore
microglial cell	13 studies	48% ± 19%	Explore
mucosal invariant T cell	13 studies	30% ± 14%	Explore
glutamatergic neuron	12 studies	83% ± 22%	Explore
CD8-positive, alpha-beta T cell	12 studies	20% ± 4%	Explore
smooth muscle cell	11 studies	41% ± 14%	Explore
GABAergic neuron	11 studies	77% ± 22%	Explore
type II pneumocyte	10 studies	58% ± 34%	Explore
endothelial cell of lymphatic vessel	10 studies	54% ± 24%	Explore
type I pneumocyte	9 studies	43% ± 21%	Explore
epithelial cell	9 studies	40% ± 23%	Explore
gamma-delta T cell	9 studies	28% ± 9%	Explore
mature NK T cell	8 studies	27% ± 13%	Explore
neuron	8 studies	54% ± 28%	Explore
pericyte	8 studies	44% ± 21%	Explore
macrophage	8 studies	47% ± 19%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	23% ± 8%	Explore
ciliated cell	8 studies	48% ± 30%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	34% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	25% ± 9%	Explore
retinal cone cell	7 studies	40% ± 17%	Explore
B cell	7 studies	39% ± 16%	Explore
adipocyte	7 studies	49% ± 15%	Explore
regulatory T cell	7 studies	20% ± 3%	Explore
basal cell	7 studies	53% ± 29%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	22% ± 2%	Explore
interneuron	6 studies	85% ± 12%	Explore
cardiac muscle cell	6 studies	56% ± 21%	Explore
mesothelial cell	6 studies	62% ± 23%	Explore
myeloid cell	6 studies	43% ± 14%	Explore
club cell	6 studies	61% ± 24%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	25% ± 9%	Explore
leukocyte	5 studies	37% ± 27%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	5 studies	26% ± 7%	Explore
amacrine cell	5 studies	70% ± 29%	Explore
endothelial cell of artery	5 studies	45% ± 23%	Explore
myofibroblast cell	5 studies	42% ± 28%	Explore
memory B cell	5 studies	21% ± 4%	Explore
granule cell	4 studies	66% ± 19%	Explore
dendritic cell	4 studies	23% ± 5%	Explore
vein endothelial cell	4 studies	37% ± 13%	Explore
retinal ganglion cell	4 studies	69% ± 20%	Explore
retinal rod cell	4 studies	53% ± 6%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	25% ± 6%	Explore
mast cell	4 studies	33% ± 16%	Explore
monocyte	4 studies	47% ± 11%	Explore
respiratory goblet cell	4 studies	64% ± 24%	Explore
renal principal cell	4 studies	66% ± 34%	Explore
cholangiocyte	3 studies	49% ± 16%	Explore
endothelial cell of sinusoid	3 studies	40% ± 8%	Explore
hepatic stellate cell	3 studies	59% ± 18%	Explore
GABAergic interneuron	3 studies	86% ± 1%	Explore
glial cell	3 studies	48% ± 14%	Explore
precursor B cell	3 studies	22% ± 3%	Explore
plasma cell	3 studies	32% ± 7%	Explore
lymphocyte	3 studies	26% ± 12%	Explore
GABAergic amacrine cell	3 studies	88% ± 5%	Explore
Mueller cell	3 studies	54% ± 19%	Explore
OFF-bipolar cell	3 studies	30% ± 6%	Explore
glycinergic amacrine cell	3 studies	81% ± 12%	Explore
T follicular helper cell	3 studies	20% ± 4%	Explore
innate lymphoid cell	3 studies	21% ± 4%	Explore
endothelial cell of vascular tree	3 studies	49% ± 6%	Explore
hepatocyte	3 studies	41% ± 28%	Explore
hematopoietic stem cell	3 studies	32% ± 21%	Explore
muscle cell	3 studies	68% ± 35%	Explore
goblet cell	3 studies	42% ± 24%	Explore
brush cell	3 studies	44% ± 16%	Explore
T-helper 17 cell	3 studies	30% ± 13%	Explore
renal alpha-intercalated cell	3 studies	73% ± 38%	Explore
mucus secreting cell	3 studies	72% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	17 studies	65% ± 23%	Explore
peripheral blood	6 studies	19% ± 4%	Explore
eye	6 studies	45% ± 17%	Explore
heart	5 studies	41% ± 15%	Explore
lung	5 studies	49% ± 14%	Explore
adipose	3 studies	38% ± 11%	Explore
kidney	3 studies	84% ± 16%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	4488.06	244 / 245	99%	9.86	495 / 502
kidney	100%	2280.87	89 / 89	98%	11.48	879 / 901
lung	100%	4094.42	576 / 578	92%	8.82	1065 / 1155
thymus	96%	1920.95	629 / 653	83%	5.39	504 / 605
esophagus	87%	1883.13	1259 / 1445	87%	5.32	160 / 183
stomach	99%	2657.03	356 / 359	74%	4.65	212 / 286
intestine	100%	4680.65	966 / 966	73%	3.60	386 / 527
bladder	100%	5181.57	21 / 21	72%	4.37	361 / 504
uterus	95%	1829.86	162 / 170	73%	5.99	337 / 459
brain	81%	1098.41	2132 / 2642	82%	4.82	576 / 705
skin	86%	1723.28	1556 / 1809	72%	4.21	342 / 472
breast	93%	1500.92	426 / 459	50%	2.51	564 / 1118
muscle	100%	14164.64	803 / 803	0%	0	0 / 0
blood vessel	98%	4676.49	1311 / 1335	0%	0	0 / 0
adipose	94%	2050.31	1136 / 1204	0%	0	0 / 0
pancreas	7%	66.15	22 / 328	88%	4.82	156 / 178
heart	93%	2910.95	802 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	84%	4.74	38 / 45
spleen	79%	955.15	191 / 241	0%	0	0 / 0
adrenal gland	5%	40.49	13 / 258	63%	3.45	144 / 230
ovary	37%	787.70	66 / 180	30%	1.07	128 / 430
lymph node	0%	0	0 / 0	66%	3.08	19 / 29
peripheral blood	63%	1344.26	589 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	46%	2.01	37 / 80
liver	10%	103.08	22 / 226	12%	0.49	49 / 406
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_1901898	Biological process	negative regulation of relaxation of cardiac muscle
GO_1902514	Biological process	regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
GO_0086004	Biological process	regulation of cardiac muscle cell contraction
GO_0019933	Biological process	cAMP-mediated signaling
GO_0002027	Biological process	regulation of heart rate
GO_0050852	Biological process	T cell receptor signaling pathway
GO_0032743	Biological process	positive regulation of interleukin-2 production
GO_0045822	Biological process	negative regulation of heart contraction
GO_0032754	Biological process	positive regulation of interleukin-5 production
GO_0061028	Biological process	establishment of endothelial barrier
GO_0032729	Biological process	positive regulation of type II interferon production
GO_0010880	Biological process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO_0033137	Biological process	negative regulation of peptidyl-serine phosphorylation
GO_0006198	Biological process	cAMP catabolic process
GO_0106072	Biological process	negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_1901844	Biological process	regulation of cell communication by electrical coupling involved in cardiac conduction
GO_0071875	Biological process	adrenergic receptor signaling pathway
GO_0010460	Biological process	positive regulation of heart rate
GO_0016324	Cellular component	apical plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005813	Cellular component	centrosome
GO_0005891	Cellular component	voltage-gated calcium channel complex
GO_0005829	Cellular component	cytosol
GO_0034704	Cellular component	calcium channel complex
GO_0005634	Cellular component	nucleus
GO_0019899	Molecular function	enzyme binding
GO_0004114	Molecular function	3',5'-cyclic-nucleotide phosphodiesterase activity
GO_0030552	Molecular function	cAMP binding
GO_1901363	Molecular function	heterocyclic compound binding
GO_0005246	Molecular function	calcium channel regulator activity
GO_0030545	Molecular function	signaling receptor regulator activity
GO_0047555	Molecular function	3',5'-cyclic-GMP phosphodiesterase activity
GO_0097110	Molecular function	scaffold protein binding
GO_0031698	Molecular function	beta-2 adrenergic receptor binding
GO_0046872	Molecular function	metal ion binding
GO_0044325	Molecular function	transmembrane transporter binding
GO_0051117	Molecular function	ATPase binding
GO_0004115	Molecular function	3',5'-cyclic-AMP phosphodiesterase activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PDE4D
Protein name	Phosphodiesterase 4D Phosphodiesterase (EC 3.1.4.-) 3',5'-cyclic-AMP phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43) (cAMP-specific phosphodiesterase 4D)
Synonyms	DPDE3 hCG_1811507
Description	FUNCTION: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. .
Accessions	ENST00000505507.6 D6RIG1 ENST00000505453.1 A0A1B0GW84 ENST00000317118.12 [Q08499-8] D6RAQ0 ENST00000405755.6 [Q08499-9] A0A140VJR0 ENST00000502575.1 [Q08499-12] ENST00000358923.10 [Q08499-5] ENST00000340635.11 [Q08499-1] ENST00000309641.10 [Q08499-7] ENST00000507116.6 [Q08499-6] ENST00000514552.5 D6RBB2 D6R9L4 ENST00000360047.9 [Q08499-2] ENST00000509368.6 D6RHE0 Q08499 ENST00000502484.6 [Q08499-11] ENST00000515835.2 ENST00000503258.5 [Q08499-10] ENST00000636120.1

PDE4D report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review