NOSIP | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
CD4-positive, alpha-beta T cell	29 studies	46% ± 19%	Explore
natural killer cell	27 studies	23% ± 7%	Explore
T cell	24 studies	31% ± 15%	Explore
CD8-positive, alpha-beta T cell	22 studies	39% ± 19%	Explore
regulatory T cell	21 studies	29% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	55% ± 21%	Explore
endothelial cell	17 studies	30% ± 12%	Explore
gamma-delta T cell	14 studies	33% ± 16%	Explore
mucosal invariant T cell	14 studies	34% ± 13%	Explore
mature NK T cell	14 studies	27% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	58% ± 22%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	27% ± 8%	Explore
B cell	12 studies	21% ± 6%	Explore
fibroblast	11 studies	24% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	29% ± 8%	Explore
classical monocyte	10 studies	24% ± 9%	Explore
endothelial cell of artery	10 studies	21% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	31% ± 19%	Explore
non-classical monocyte	9 studies	24% ± 9%	Explore
capillary endothelial cell	9 studies	23% ± 7%	Explore
pericyte	9 studies	23% ± 7%	Explore
vein endothelial cell	9 studies	21% ± 7%	Explore
naive B cell	9 studies	18% ± 3%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	44% ± 17%	Explore
plasmacytoid dendritic cell	8 studies	24% ± 6%	Explore
memory B cell	8 studies	19% ± 4%	Explore
myofibroblast cell	7 studies	22% ± 4%	Explore
smooth muscle cell	7 studies	24% ± 6%	Explore
epithelial cell	7 studies	38% ± 22%	Explore
ciliated cell	7 studies	29% ± 11%	Explore
T follicular helper cell	7 studies	33% ± 17%	Explore
abnormal cell	7 studies	29% ± 21%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	37% ± 16%	Explore
connective tissue cell	6 studies	24% ± 6%	Explore
basal cell	6 studies	28% ± 10%	Explore
endothelial cell of lymphatic vessel	6 studies	24% ± 6%	Explore
macrophage	6 studies	22% ± 7%	Explore
endothelial cell of vascular tree	6 studies	23% ± 5%	Explore
CD4-positive helper T cell	5 studies	24% ± 13%	Explore
monocyte	5 studies	21% ± 4%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	50% ± 17%	Explore
conventional dendritic cell	5 studies	32% ± 15%	Explore
T-helper 17 cell	5 studies	34% ± 21%	Explore
precursor B cell	5 studies	26% ± 7%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	37% ± 12%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	57% ± 8%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	43% ± 23%	Explore
hematopoietic precursor cell	4 studies	25% ± 9%	Explore
plasma cell	4 studies	27% ± 11%	Explore
plasmablast	4 studies	46% ± 18%	Explore
leukocyte	4 studies	22% ± 5%	Explore
exhausted T cell	4 studies	42% ± 20%	Explore
neuron	4 studies	29% ± 14%	Explore
enteroendocrine cell	4 studies	29% ± 13%	Explore
goblet cell	4 studies	26% ± 9%	Explore
double negative thymocyte	4 studies	44% ± 13%	Explore
platelet	3 studies	18% ± 1%	Explore
glomerular endothelial cell	3 studies	18% ± 2%	Explore
neural crest cell	3 studies	17% ± 1%	Explore
lymphocyte	3 studies	26% ± 7%	Explore
immature B cell	3 studies	23% ± 5%	Explore
pro-B cell	3 studies	24% ± 2%	Explore
retinal cone cell	3 studies	42% ± 11%	Explore
erythroblast	3 studies	30% ± 17%	Explore
innate lymphoid cell	3 studies	25% ± 6%	Explore
glutamatergic neuron	3 studies	27% ± 8%	Explore
dendritic cell	3 studies	35% ± 13%	Explore
granulocyte	3 studies	22% ± 5%	Explore
intestinal crypt stem cell	3 studies	26% ± 6%	Explore
secretory cell	3 studies	21% ± 4%	Explore
T-helper 1 cell	3 studies	42% ± 21%	Explore
hematopoietic stem cell	3 studies	18% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	26% ± 8%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	66% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	18 studies	34% ± 10%	Explore
lung	9 studies	25% ± 7%	Explore
intestine	6 studies	22% ± 10%	Explore
brain	4 studies	22% ± 4%	Explore
lymph node	4 studies	27% ± 10%	Explore
liver	4 studies	26% ± 15%	Explore
kidney	3 studies	20% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1888.92	1445 / 1445	100%	22.00	183 / 183
liver	100%	1208.63	226 / 226	100%	29.45	406 / 406
ovary	100%	1999.84	180 / 180	100%	32.39	430 / 430
pancreas	100%	3075.25	328 / 328	100%	37.77	178 / 178
thymus	100%	2115.68	653 / 653	100%	43.95	605 / 605
brain	100%	1650.35	2637 / 2642	100%	37.00	705 / 705
uterus	100%	2413.02	170 / 170	100%	56.26	458 / 459
stomach	100%	1603.29	359 / 359	100%	39.94	285 / 286
skin	100%	1953.67	1809 / 1809	100%	38.70	470 / 472
adrenal gland	100%	2099.84	258 / 258	100%	31.22	229 / 230
kidney	100%	1992.84	89 / 89	99%	26.82	896 / 901
intestine	100%	2242.52	966 / 966	99%	46.40	524 / 527
bladder	100%	1914.24	21 / 21	99%	46.50	500 / 504
prostate	100%	2213.31	245 / 245	99%	34.93	498 / 502
breast	100%	2044.14	459 / 459	99%	34.48	1109 / 1118
lung	100%	1907.37	577 / 578	99%	29.55	1141 / 1155
adipose	100%	1932.31	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	39.73	80 / 80
lymph node	0%	0	0 / 0	100%	91.30	29 / 29
muscle	100%	2766.85	803 / 803	0%	0	0 / 0
spleen	100%	3122.44	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	48.31	45 / 45
ureter	0%	0	0 / 0	100%	51.41	1 / 1
blood vessel	100%	1854.93	1333 / 1335	0%	0	0 / 0
heart	100%	1601.56	858 / 861	0%	0	0 / 0
peripheral blood	100%	3208.22	925 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0051001	Biological process	negative regulation of nitric-oxide synthase activity
GO_0043086	Biological process	negative regulation of catalytic activity
GO_0045428	Biological process	regulation of nitric oxide biosynthetic process
GO_0000139	Cellular component	Golgi membrane
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0061630	Molecular function	ubiquitin protein ligase activity
GO_0140313	Molecular function	molecular sequestering activity
GO_0005515	Molecular function	protein binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	NOSIP
Protein name	Nitric oxide synthase-interacting protein Nitric oxide synthase-interacting protein (E3 ubiquitin-protein ligase NOSIP) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase NOSIP) (eNOS-interacting protein) Nitric oxide synthase interacting protein Nitric oxide synthase-interacting protein (E3 ubiquitin-protein ligase NOSIP) (RING-type E3 ubiquitin transferase NOSIP)
Synonyms	CGI-25
Description	FUNCTION: E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity . . FUNCTION: Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity. .
Accessions	M0R1K2 ENST00000598296.5 M0R3B2 ENST00000599537.5 M0R1T7 ENST00000596358.6 ENST00000600019.5 ENST00000598544.1 M0QX85 A0A075B6F9 ENST00000594932.5 A0A075B797 ENST00000339093.7 Q9Y314 ENST00000601015.5

NOSIP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review