MESD | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	23 studies	25% ± 10%	Explore
fibroblast	22 studies	27% ± 12%	Explore
natural killer cell	21 studies	22% ± 6%	Explore
macrophage	16 studies	21% ± 7%	Explore
regulatory T cell	15 studies	23% ± 6%	Explore
CD8-positive, alpha-beta T cell	14 studies	23% ± 4%	Explore
CD4-positive, alpha-beta T cell	12 studies	21% ± 5%	Explore
plasma cell	11 studies	39% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	21% ± 4%	Explore
connective tissue cell	11 studies	25% ± 7%	Explore
epithelial cell	10 studies	37% ± 18%	Explore
gamma-delta T cell	10 studies	22% ± 11%	Explore
plasmacytoid dendritic cell	10 studies	29% ± 9%	Explore
plasmablast	9 studies	44% ± 23%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	21% ± 4%	Explore
basal cell	9 studies	33% ± 16%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	19% ± 3%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	21% ± 4%	Explore
mature NK T cell	9 studies	20% ± 4%	Explore
capillary endothelial cell	9 studies	24% ± 7%	Explore
mucosal invariant T cell	9 studies	20% ± 4%	Explore
pericyte	9 studies	22% ± 4%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	22% ± 5%	Explore
T cell	8 studies	19% ± 2%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	19% ± 2%	Explore
conventional dendritic cell	8 studies	25% ± 10%	Explore
vein endothelial cell	8 studies	25% ± 10%	Explore
smooth muscle cell	8 studies	19% ± 3%	Explore
endothelial cell of lymphatic vessel	7 studies	24% ± 5%	Explore
classical monocyte	7 studies	20% ± 6%	Explore
myofibroblast cell	7 studies	18% ± 2%	Explore
abnormal cell	7 studies	23% ± 7%	Explore
endothelial cell of artery	7 studies	19% ± 5%	Explore
B cell	7 studies	18% ± 4%	Explore
mast cell	6 studies	20% ± 5%	Explore
non-classical monocyte	6 studies	21% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	21% ± 4%	Explore
ciliated cell	6 studies	35% ± 14%	Explore
secretory cell	5 studies	30% ± 16%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	27% ± 6%	Explore
myeloid cell	5 studies	26% ± 8%	Explore
astrocyte	5 studies	28% ± 3%	Explore
T follicular helper cell	5 studies	17% ± 1%	Explore
neuron	5 studies	23% ± 9%	Explore
goblet cell	5 studies	24% ± 8%	Explore
club cell	4 studies	23% ± 7%	Explore
monocyte	4 studies	19% ± 4%	Explore
hematopoietic precursor cell	4 studies	27% ± 3%	Explore
progenitor cell	4 studies	23% ± 5%	Explore
mesothelial cell	4 studies	29% ± 15%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	26% ± 3%	Explore
endothelial cell of vascular tree	4 studies	21% ± 3%	Explore
innate lymphoid cell	4 studies	21% ± 1%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	25% ± 6%	Explore
oligodendrocyte	4 studies	25% ± 6%	Explore
hematopoietic stem cell	4 studies	16% ± 1%	Explore
respiratory goblet cell	3 studies	28% ± 15%	Explore
leukocyte	3 studies	22% ± 6%	Explore
glomerular endothelial cell	3 studies	26% ± 5%	Explore
neural crest cell	3 studies	19% ± 1%	Explore
extravillous trophoblast	3 studies	41% ± 12%	Explore
placental villous trophoblast	3 studies	69% ± 15%	Explore
lymphocyte	3 studies	23% ± 9%	Explore
type I pneumocyte	3 studies	27% ± 5%	Explore
retinal rod cell	3 studies	19% ± 3%	Explore
Mueller cell	3 studies	24% ± 6%	Explore
exhausted T cell	3 studies	23% ± 5%	Explore
GABAergic neuron	3 studies	29% ± 2%	Explore
glutamatergic neuron	3 studies	39% ± 4%	Explore
dendritic cell	3 studies	43% ± 8%	Explore
enteroendocrine cell	3 studies	27% ± 11%	Explore
intestinal crypt stem cell	3 studies	21% ± 3%	Explore
group 3 innate lymphoid cell	3 studies	25% ± 11%	Explore
transit amplifying cell	3 studies	19% ± 3%	Explore
double negative thymocyte	3 studies	29% ± 11%	Explore
microglial cell	3 studies	22% ± 2%	Explore
oligodendrocyte precursor cell	3 studies	20% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	11 studies	26% ± 13%	Explore
peripheral blood	11 studies	20% ± 3%	Explore
brain	6 studies	28% ± 4%	Explore
intestine	5 studies	23% ± 10%	Explore
liver	4 studies	25% ± 8%	Explore
kidney	3 studies	20% ± 2%	Explore
placenta	3 studies	49% ± 14%	Explore
uterus	3 studies	29% ± 16%	Explore
bone marrow	3 studies	18% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2156.11	1445 / 1445	100%	24.49	183 / 183
intestine	100%	2196.83	966 / 966	100%	29.30	527 / 527
liver	100%	2287.23	226 / 226	100%	23.11	406 / 406
lung	100%	3062.46	578 / 578	100%	32.15	1155 / 1155
stomach	100%	2104.55	359 / 359	100%	25.16	286 / 286
thymus	100%	5410.08	653 / 653	100%	58.97	605 / 605
brain	100%	2004.82	2640 / 2642	100%	29.32	705 / 705
breast	100%	2653.52	459 / 459	100%	35.54	1117 / 1118
prostate	100%	2610.62	245 / 245	100%	39.44	501 / 502
uterus	100%	2631.86	170 / 170	100%	36.49	458 / 459
pancreas	100%	2247.01	327 / 328	100%	29.08	178 / 178
bladder	100%	2401.00	21 / 21	100%	29.56	502 / 504
skin	100%	3276.34	1809 / 1809	100%	44.97	470 / 472
ovary	100%	3510.39	180 / 180	100%	21.03	428 / 430
kidney	100%	2309.00	89 / 89	99%	28.01	896 / 901
adrenal gland	100%	3404.69	258 / 258	98%	28.95	226 / 230
adipose	100%	2778.36	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	23.95	29 / 29
spleen	100%	2814.55	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	29.79	45 / 45
ureter	0%	0	0 / 0	100%	13.14	1 / 1
blood vessel	100%	2445.13	1332 / 1335	0%	0	0 / 0
heart	99%	1718.27	851 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	99%	26.83	79 / 80
muscle	92%	750.38	740 / 803	0%	0	0 / 0
peripheral blood	84%	1368.74	783 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006457	Biological process	protein folding
GO_0007498	Biological process	mesoderm development
GO_1904395	Biological process	positive regulation of skeletal muscle acetylcholine-gated channel clustering
GO_0001503	Biological process	ossification
GO_0016055	Biological process	Wnt signaling pathway
GO_0034394	Biological process	protein localization to cell surface
GO_0006909	Biological process	phagocytosis
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005886	Cellular component	plasma membrane
GO_0050750	Molecular function	low-density lipoprotein particle receptor binding
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding
GO_0003674	Molecular function	molecular_function

IV. Literature review

[source]

Gene name	MESD
Protein name	LRP chaperone MESD (LDLR chaperone MESD) (Mesoderm development LRP chaperone MESD) (Mesoderm development candidate 2) (Mesoderm development protein) (Renal carcinoma antigen NY-REN-61) LRP chaperone MESD (LDLR chaperone MESD) (Mesoderm development candidate 2) (Mesoderm development protein)
Synonyms	MESDM MESDC2 KIAA0081 UNQ1911/PRO4369
Description	FUNCTION: Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs) . Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane . Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4 (By similarity). May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells (By similarity). .
Accessions	H0YLI4 Q14696 ENST00000619987.4 [Q14696-1] ENST00000422879.3 [Q14696-2] ENST00000261758.6 [Q14696-1] ENST00000559537.1 ENST00000561312.5 [Q14696-1]

MESD report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review