LSM2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	26 studies	28% ± 11%	Explore
B cell	25 studies	30% ± 9%	Explore
CD8-positive, alpha-beta T cell	20 studies	36% ± 15%	Explore
T cell	19 studies	28% ± 10%	Explore
endothelial cell	19 studies	31% ± 14%	Explore
regulatory T cell	17 studies	29% ± 11%	Explore
CD4-positive, alpha-beta T cell	16 studies	34% ± 20%	Explore
fibroblast	16 studies	26% ± 11%	Explore
memory B cell	15 studies	27% ± 9%	Explore
naive B cell	14 studies	25% ± 7%	Explore
mast cell	13 studies	24% ± 4%	Explore
endothelial cell of lymphatic vessel	13 studies	27% ± 10%	Explore
pericyte	13 studies	26% ± 8%	Explore
smooth muscle cell	13 studies	26% ± 8%	Explore
gamma-delta T cell	13 studies	31% ± 16%	Explore
macrophage	12 studies	22% ± 9%	Explore
conventional dendritic cell	12 studies	27% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	27% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	25% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	30% ± 7%	Explore
mature NK T cell	10 studies	28% ± 10%	Explore
connective tissue cell	10 studies	32% ± 8%	Explore
epithelial cell	10 studies	36% ± 20%	Explore
vein endothelial cell	10 studies	25% ± 11%	Explore
mucosal invariant T cell	9 studies	21% ± 5%	Explore
endothelial cell of vascular tree	9 studies	23% ± 5%	Explore
plasma cell	8 studies	31% ± 16%	Explore
basal cell	8 studies	31% ± 14%	Explore
classical monocyte	8 studies	22% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	20% ± 4%	Explore
myofibroblast cell	8 studies	31% ± 8%	Explore
endothelial cell of artery	8 studies	22% ± 6%	Explore
plasmacytoid dendritic cell	8 studies	27% ± 8%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	33% ± 14%	Explore
T follicular helper cell	7 studies	20% ± 5%	Explore
abnormal cell	7 studies	32% ± 11%	Explore
plasmablast	6 studies	50% ± 20%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	31% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	25% ± 8%	Explore
capillary endothelial cell	6 studies	27% ± 14%	Explore
hematopoietic stem cell	6 studies	42% ± 18%	Explore
hematopoietic precursor cell	5 studies	48% ± 23%	Explore
non-classical monocyte	5 studies	22% ± 4%	Explore
progenitor cell	5 studies	32% ± 6%	Explore
erythroblast	5 studies	37% ± 19%	Explore
precursor B cell	5 studies	37% ± 14%	Explore
pro-B cell	5 studies	33% ± 6%	Explore
myeloid cell	5 studies	22% ± 9%	Explore
dendritic cell	5 studies	35% ± 20%	Explore
immature B cell	5 studies	33% ± 16%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	40% ± 13%	Explore
innate lymphoid cell	5 studies	22% ± 6%	Explore
exhausted T cell	4 studies	41% ± 9%	Explore
monocyte	4 studies	20% ± 6%	Explore
goblet cell	4 studies	26% ± 13%	Explore
intestinal crypt stem cell	4 studies	25% ± 7%	Explore
transit amplifying cell	4 studies	24% ± 5%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	41% ± 9%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	29% ± 13%	Explore
precursor cell	3 studies	46% ± 15%	Explore
pancreatic A cell	3 studies	35% ± 17%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	32% ± 12%	Explore
leukocyte	3 studies	31% ± 11%	Explore
mesothelial cell	3 studies	33% ± 17%	Explore
neural crest cell	3 studies	40% ± 7%	Explore
lymphocyte	3 studies	32% ± 11%	Explore
ciliated cell	3 studies	37% ± 5%	Explore
intraepithelial lymphocyte	3 studies	38% ± 11%	Explore
germinal center B cell	3 studies	32% ± 1%	Explore
intermediate monocyte	3 studies	27% ± 11%	Explore
neuron	3 studies	32% ± 13%	Explore
granulocyte monocyte progenitor cell	3 studies	37% ± 23%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	50% ± 28%	Explore
enteroendocrine cell	3 studies	33% ± 10%	Explore
erythrocyte	3 studies	44% ± 20%	Explore
group 3 innate lymphoid cell	3 studies	33% ± 16%	Explore
T-helper 17 cell	3 studies	38% ± 27%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	19% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	11 studies	26% ± 8%	Explore
lung	10 studies	27% ± 11%	Explore
intestine	6 studies	27% ± 12%	Explore
bone marrow	5 studies	17% ± 1%	Explore
lymph node	5 studies	22% ± 4%	Explore
kidney	4 studies	24% ± 4%	Explore
liver	4 studies	30% ± 24%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1279.23	1445 / 1445	100%	88.06	183 / 183
ovary	100%	1376.48	180 / 180	100%	203.06	430 / 430
skin	100%	1535.73	1809 / 1809	100%	161.02	472 / 472
stomach	100%	1073.52	359 / 359	100%	126.85	286 / 286
brain	100%	933.34	2638 / 2642	100%	138.86	705 / 705
uterus	100%	1796.66	170 / 170	100%	175.49	458 / 459
thymus	100%	1259.46	653 / 653	100%	114.47	603 / 605
intestine	100%	1472.40	966 / 966	100%	146.94	525 / 527
breast	100%	1467.97	459 / 459	100%	137.87	1113 / 1118
bladder	100%	1518.95	21 / 21	99%	156.20	501 / 504
prostate	100%	1209.58	245 / 245	99%	83.40	499 / 502
lung	100%	1257.25	577 / 578	99%	132.51	1149 / 1155
pancreas	99%	798.72	326 / 328	99%	93.05	177 / 178
liver	100%	597.11	226 / 226	98%	81.83	399 / 406
adrenal gland	100%	1298.82	258 / 258	95%	65.61	218 / 230
kidney	100%	1241.25	89 / 89	93%	65.30	841 / 901
adipose	100%	1369.74	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	178.61	80 / 80
lymph node	0%	0	0 / 0	100%	225.92	29 / 29
spleen	100%	1621.19	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	144.81	45 / 45
ureter	0%	0	0 / 0	100%	121.86	1 / 1
blood vessel	100%	1373.22	1334 / 1335	0%	0	0 / 0
muscle	100%	938.72	800 / 803	0%	0	0 / 0
heart	100%	770.33	857 / 861	0%	0	0 / 0
peripheral blood	98%	1523.51	915 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000244	Biological process	spliceosomal tri-snRNP complex assembly
GO_0006402	Biological process	mRNA catabolic process
GO_0000398	Biological process	mRNA splicing, via spliceosome
GO_0046540	Cellular component	U4/U6 x U5 tri-snRNP complex
GO_0120115	Cellular component	Lsm2-8 complex
GO_1990726	Cellular component	Lsm1-7-Pat1 complex
GO_0005654	Cellular component	nucleoplasm
GO_0071005	Cellular component	U2-type precatalytic spliceosome
GO_0000932	Cellular component	P-body
GO_0071011	Cellular component	precatalytic spliceosome
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0071013	Cellular component	catalytic step 2 spliceosome
GO_0005688	Cellular component	U6 snRNP
GO_0005634	Cellular component	nucleus
GO_0031267	Molecular function	small GTPase binding
GO_0017070	Molecular function	U6 snRNA binding
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	LSM2
Protein name	U6 snRNA-associated Sm-like protein LSm2 (Protein G7b) (Small nuclear ribonuclear protein D homolog) (snRNP core Sm-like protein Sm-x5)
Synonyms	G7B C6orf28
Description	FUNCTION: Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) . The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA . .
Accessions	ENST00000455705.2 ENST00000434125.2 ENST00000432122.2 ENST00000383391.4 ENST00000375661.6 ENST00000424975.2 Q9Y333

LSM2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review