LRBA | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	22 studies	42% ± 15%	Explore
astrocyte	19 studies	43% ± 20%	Explore
oligodendrocyte	15 studies	40% ± 16%	Explore
microglial cell	15 studies	48% ± 17%	Explore
ciliated cell	14 studies	44% ± 22%	Explore
CD8-positive, alpha-beta T cell	14 studies	27% ± 14%	Explore
T cell	13 studies	36% ± 19%	Explore
natural killer cell	13 studies	29% ± 15%	Explore
oligodendrocyte precursor cell	13 studies	49% ± 17%	Explore
regulatory T cell	13 studies	28% ± 14%	Explore
macrophage	12 studies	37% ± 16%	Explore
GABAergic neuron	11 studies	49% ± 24%	Explore
glutamatergic neuron	11 studies	59% ± 24%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	21% ± 10%	Explore
fibroblast	11 studies	39% ± 11%	Explore
epithelial cell	10 studies	48% ± 21%	Explore
B cell	10 studies	37% ± 19%	Explore
CD4-positive, alpha-beta T cell	9 studies	31% ± 16%	Explore
pericyte	9 studies	33% ± 12%	Explore
mucosal invariant T cell	9 studies	24% ± 13%	Explore
adipocyte	9 studies	39% ± 11%	Explore
mast cell	9 studies	30% ± 11%	Explore
smooth muscle cell	9 studies	32% ± 10%	Explore
gamma-delta T cell	9 studies	20% ± 3%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	27% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	28% ± 15%	Explore
basal cell	8 studies	45% ± 25%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	23% ± 6%	Explore
retinal cone cell	7 studies	56% ± 31%	Explore
dendritic cell	7 studies	36% ± 14%	Explore
endothelial cell of lymphatic vessel	7 studies	44% ± 13%	Explore
type I pneumocyte	7 studies	54% ± 24%	Explore
neuron	6 studies	55% ± 25%	Explore
interneuron	6 studies	57% ± 25%	Explore
type II pneumocyte	6 studies	59% ± 20%	Explore
club cell	6 studies	53% ± 25%	Explore
naive B cell	5 studies	17% ± 2%	Explore
retina horizontal cell	5 studies	64% ± 28%	Explore
cardiac muscle cell	5 studies	47% ± 10%	Explore
respiratory goblet cell	5 studies	47% ± 26%	Explore
myeloid cell	5 studies	33% ± 5%	Explore
mature NK T cell	5 studies	28% ± 18%	Explore
hematopoietic stem cell	5 studies	29% ± 8%	Explore
monocyte	5 studies	32% ± 11%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	18% ± 2%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	33% ± 16%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	19% ± 3%	Explore
granule cell	4 studies	45% ± 11%	Explore
plasma cell	4 studies	41% ± 10%	Explore
mesothelial cell	4 studies	42% ± 13%	Explore
lymphocyte	4 studies	51% ± 23%	Explore
Mueller cell	4 studies	59% ± 21%	Explore
amacrine cell	4 studies	69% ± 13%	Explore
retinal rod cell	4 studies	56% ± 14%	Explore
goblet cell	4 studies	40% ± 30%	Explore
leukocyte	4 studies	62% ± 13%	Explore
hematopoietic precursor cell	3 studies	41% ± 14%	Explore
ionocyte	3 studies	29% ± 3%	Explore
cholangiocyte	3 studies	59% ± 16%	Explore
exhausted T cell	3 studies	27% ± 5%	Explore
GABAergic interneuron	3 studies	44% ± 4%	Explore
progenitor cell	3 studies	32% ± 12%	Explore
vein endothelial cell	3 studies	38% ± 17%	Explore
GABAergic amacrine cell	3 studies	63% ± 18%	Explore
glycinergic amacrine cell	3 studies	69% ± 11%	Explore
retinal ganglion cell	3 studies	57% ± 18%	Explore
endothelial cell of vascular tree	3 studies	41% ± 13%	Explore
hepatocyte	3 studies	73% ± 19%	Explore
retinal pigment epithelial cell	3 studies	65% ± 21%	Explore
ependymal cell	3 studies	62% ± 7%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	38% ± 15%	Explore
enteroendocrine cell	3 studies	32% ± 11%	Explore
alveolar macrophage	3 studies	39% ± 7%	Explore
capillary endothelial cell	3 studies	30% ± 8%	Explore
group 3 innate lymphoid cell	3 studies	21% ± 7%	Explore
muscle cell	3 studies	27% ± 16%	Explore
transit amplifying cell	3 studies	44% ± 34%	Explore
brush cell	3 studies	25% ± 6%	Explore
double negative thymocyte	3 studies	23% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	34% ± 20%	Explore
platelet	3 studies	21% ± 4%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	67% ± 33%	Explore
kidney loop of Henle epithelial cell	3 studies	63% ± 33%	Explore
renal principal cell	3 studies	55% ± 26%	Explore
mural cell	3 studies	49% ± 13%	Explore
abnormal cell	3 studies	36% ± 25%	Explore
mucus secreting cell	3 studies	55% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	17 studies	47% ± 21%	Explore
lung	7 studies	37% ± 17%	Explore
eye	5 studies	58% ± 14%	Explore
heart	4 studies	37% ± 5%	Explore
liver	4 studies	38% ± 22%	Explore
kidney	4 studies	53% ± 23%	Explore
intestine	3 studies	19% ± 1%	Explore
adipose	3 studies	39% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	3081.61	245 / 245	100%	37.82	502 / 502
esophagus	100%	2987.81	1441 / 1445	99%	22.42	182 / 183
thymus	100%	3871.41	653 / 653	99%	24.44	600 / 605
intestine	100%	4107.06	966 / 966	99%	19.61	522 / 527
breast	100%	3077.35	459 / 459	99%	43.38	1105 / 1118
stomach	100%	2843.57	359 / 359	98%	19.75	280 / 286
lung	99%	2850.56	575 / 578	98%	17.68	1136 / 1155
pancreas	100%	2313.86	327 / 328	98%	16.69	174 / 178
kidney	100%	3408.20	89 / 89	97%	17.96	874 / 901
bladder	100%	2409.24	21 / 21	97%	15.96	487 / 504
uterus	100%	2095.71	170 / 170	94%	12.47	432 / 459
ovary	100%	2435.21	180 / 180	92%	10.61	396 / 430
adrenal gland	100%	3824.16	258 / 258	90%	12.40	208 / 230
skin	100%	4983.88	1809 / 1809	89%	10.62	420 / 472
brain	91%	1172.45	2404 / 2642	86%	6.79	605 / 705
liver	100%	1652.56	226 / 226	62%	5.76	250 / 406
spleen	100%	2228.44	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	9.45	1 / 1
blood vessel	100%	2284.29	1333 / 1335	0%	0	0 / 0
adipose	100%	1940.21	1202 / 1204	0%	0	0 / 0
muscle	97%	1248.31	782 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	15.46	43 / 45
lymph node	0%	0	0 / 0	93%	11.33	27 / 29
heart	91%	1680.85	780 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	81%	7.78	65 / 80
peripheral blood	51%	2681.48	476 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000423	Biological process	mitophagy
GO_0008104	Biological process	protein localization
GO_0034497	Biological process	protein localization to phagophore assembly site
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005829	Cellular component	cytosol
GO_0005794	Cellular component	Golgi apparatus
GO_0005886	Cellular component	plasma membrane
GO_0005765	Cellular component	lysosomal membrane
GO_0016020	Cellular component	membrane
GO_0019901	Molecular function	protein kinase binding
GO_0005515	Molecular function	protein binding
GO_0003674	Molecular function	molecular_function

IV. Literature review

[source]

Gene name	LRBA
Protein name	Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) LRBA protein LPS responsive beige-like anchor protein
Synonyms	LBA CDC4L BGL
Description	FUNCTION: Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria . .
Accessions	ENST00000651035.1 A0A8V8TKR0 A0A3B3ISK3 ENST00000648823.1 A0A3B3IS13 A0A494BZW2 ENST00000648878.1 ENST00000648626.1 ENST00000508606.1 A0A8V8TM79 ENST00000502839.1 ENST00000651695.2 A0A3B3IU76 ENST00000510413.5 [P50851-2] ENST00000649874.1 ENST00000503716.5 ENST00000697128.1 ENST00000697127.1 ENST00000651943.2 ENST00000507224.5 Q969R7 P50851 A0A494C1L5 H0Y9N9 ENST00000357115.9 [P50851-1] A0A8V8TLZ6 E9PEM5 A0A494C0R9 A0A8V8TL26 H0YA17 Q6P1X2

LRBA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review