LCK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006919Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0050870Biological processpositive regulation of T cell activation
GO_0050862Biological processpositive regulation of T cell receptor signaling pathway
GO_0030097Biological processhemopoiesis
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0051249Biological processregulation of lymphocyte activation
GO_0045087Biological processinnate immune response
GO_0031295Biological processT cell costimulation
GO_0050853Biological processB cell receptor signaling pathway
GO_2001244Biological processpositive regulation of intrinsic apoptotic signaling pathway
GO_1903039Biological processpositive regulation of leukocyte cell-cell adhesion
GO_0051209Biological processrelease of sequestered calcium ion into cytosol
GO_0050852Biological processT cell receptor signaling pathway
GO_0030168Biological processplatelet activation
GO_0038083Biological processpeptidyl-tyrosine autophosphorylation
GO_0030217Biological processT cell differentiation
GO_0018108Biological processpeptidyl-tyrosine phosphorylation
GO_0035556Biological processintracellular signal transduction
GO_0050900Biological processleukocyte migration
GO_0006882Biological processintracellular zinc ion homeostasis
GO_0034116Biological processpositive regulation of heterotypic cell-cell adhesion
GO_0006468Biological processprotein phosphorylation
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0038094Biological processFc-gamma receptor signaling pathway
GO_0001772Cellular componentimmunological synapse
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0000242Cellular componentpericentriolar material
GO_0016004Molecular functionphospholipase activator activity
GO_0004715Molecular functionnon-membrane spanning protein tyrosine kinase activity
GO_0043548Molecular functionphosphatidylinositol 3-kinase binding
GO_0042608Molecular functionT cell receptor binding
GO_0042610Molecular functionCD8 receptor binding
GO_0019903Molecular functionprotein phosphatase binding
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0019901Molecular functionprotein kinase binding
GO_0005102Molecular functionsignaling receptor binding
GO_0042802Molecular functionidentical protein binding
GO_0042169Molecular functionSH2 domain binding
GO_0043274Molecular functionphospholipase binding
GO_0005524Molecular functionATP binding
GO_0051117Molecular functionATPase binding
GO_0004722Molecular functionprotein serine/threonine phosphatase activity
GO_0042609Molecular functionCD4 receptor binding
GO_0005515Molecular functionprotein binding
GO_0001784Molecular functionphosphotyrosine residue binding

IV. Literature review

[source]
Gene nameLCK
Protein nameTyrosine-protein kinase (EC 2.7.10.2)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
LCK proto-oncogene, Src family tyrosine kinase
SynonymshCG_41609
DescriptionFUNCTION: Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. Interacts with FYB2 . .

AccessionsQ573B4
E9PKQ8
P06239
ENST00000696991.1
E9PQ10
F8W6B9
ENST00000495610.7
ENST00000696990.1
E9PJ92
E9PAP0
A0A0S2Z3T3
E9PI33
ENST00000373557.6
A0A0S2Z3Y8
ENST00000482949.6
ENST00000333070.4 [P06239-3]
ENST00000477031.6
ENST00000461712.6
ENST00000336890.10 [P06239-1]
A0A8V8TKX3
A0A8V8TM09
ENST00000373562.7