LBR | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	26 studies	26% ± 8%	Explore
B cell	24 studies	26% ± 8%	Explore
CD4-positive, alpha-beta T cell	19 studies	23% ± 9%	Explore
CD8-positive, alpha-beta T cell	19 studies	26% ± 8%	Explore
regulatory T cell	18 studies	23% ± 5%	Explore
naive B cell	16 studies	22% ± 4%	Explore
classical monocyte	16 studies	25% ± 10%	Explore
T cell	14 studies	25% ± 8%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	27% ± 6%	Explore
gamma-delta T cell	14 studies	26% ± 12%	Explore
endothelial cell	13 studies	26% ± 11%	Explore
memory B cell	13 studies	19% ± 3%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	23% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	25% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	23% ± 3%	Explore
plasmacytoid dendritic cell	11 studies	24% ± 6%	Explore
monocyte	10 studies	27% ± 10%	Explore
mature NK T cell	10 studies	21% ± 4%	Explore
endothelial cell of lymphatic vessel	9 studies	23% ± 7%	Explore
smooth muscle cell	9 studies	26% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	24% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	24% ± 4%	Explore
mucosal invariant T cell	9 studies	23% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	21% ± 3%	Explore
plasmablast	7 studies	38% ± 21%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	31% ± 10%	Explore
macrophage	7 studies	22% ± 3%	Explore
conventional dendritic cell	6 studies	34% ± 14%	Explore
precursor B cell	6 studies	43% ± 19%	Explore
epithelial cell	6 studies	39% ± 11%	Explore
pericyte	6 studies	18% ± 4%	Explore
hematopoietic precursor cell	5 studies	34% ± 14%	Explore
interneuron	5 studies	24% ± 11%	Explore
pro-B cell	5 studies	34% ± 11%	Explore
myeloid cell	5 studies	32% ± 7%	Explore
immature B cell	5 studies	35% ± 13%	Explore
T follicular helper cell	5 studies	20% ± 3%	Explore
GABAergic neuron	5 studies	23% ± 6%	Explore
neutrophil	5 studies	24% ± 6%	Explore
erythrocyte	5 studies	31% ± 16%	Explore
plasma cell	4 studies	31% ± 12%	Explore
leukocyte	4 studies	25% ± 7%	Explore
exhausted T cell	4 studies	30% ± 7%	Explore
non-classical monocyte	4 studies	28% ± 7%	Explore
myofibroblast cell	4 studies	25% ± 9%	Explore
transit amplifying cell	4 studies	25% ± 5%	Explore
lymphocyte	4 studies	25% ± 5%	Explore
endothelial cell of artery	4 studies	16% ± 1%	Explore
glutamatergic neuron	4 studies	25% ± 9%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	24% ± 5%	Explore
basal cell	4 studies	20% ± 3%	Explore
astrocyte	4 studies	21% ± 1%	Explore
oligodendrocyte	4 studies	22% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	23% ± 4%	Explore
abnormal cell	3 studies	25% ± 4%	Explore
microglial cell	3 studies	23% ± 3%	Explore
capillary endothelial cell	3 studies	18% ± 3%	Explore
ciliated cell	3 studies	26% ± 5%	Explore
erythroblast	3 studies	60% ± 31%	Explore
germinal center B cell	3 studies	35% ± 9%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	27% ± 6%	Explore
innate lymphoid cell	3 studies	20% ± 3%	Explore
oligodendrocyte precursor cell	3 studies	29% ± 8%	Explore
dendritic cell	3 studies	38% ± 16%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	34% ± 14%	Explore
goblet cell	3 studies	19% ± 5%	Explore
intestinal crypt stem cell	3 studies	23% ± 3%	Explore
neuron	3 studies	29% ± 1%	Explore
T-helper 1 cell	3 studies	21% ± 3%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	24% ± 3%	Explore
double negative thymocyte	3 studies	36% ± 8%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	26% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	15 studies	25% ± 9%	Explore
brain	5 studies	23% ± 5%	Explore
bone marrow	5 studies	23% ± 7%	Explore
lung	4 studies	23% ± 2%	Explore
intestine	3 studies	23% ± 8%	Explore
liver	3 studies	42% ± 27%	Explore
lymph node	3 studies	20% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	6105.88	1445 / 1445	100%	67.40	183 / 183
stomach	100%	4544.60	359 / 359	100%	79.90	285 / 286
lung	99%	3460.11	575 / 578	100%	51.91	1155 / 1155
intestine	100%	8927.40	966 / 966	99%	85.34	524 / 527
uterus	100%	7472.04	170 / 170	99%	54.15	454 / 459
liver	100%	2373.77	226 / 226	98%	46.50	399 / 406
bladder	100%	5926.81	21 / 21	98%	53.08	494 / 504
prostate	100%	3638.33	244 / 245	98%	33.36	491 / 502
pancreas	96%	1745.74	316 / 328	98%	35.70	174 / 178
breast	100%	3331.10	459 / 459	93%	29.01	1037 / 1118
kidney	100%	2228.61	89 / 89	89%	31.82	801 / 901
ovary	100%	3426.84	180 / 180	86%	19.65	368 / 430
skin	99%	2573.65	1796 / 1809	85%	26.90	403 / 472
thymus	100%	2429.90	650 / 653	79%	22.91	476 / 605
brain	66%	826.25	1743 / 2642	98%	32.30	694 / 705
adrenal gland	72%	822.69	185 / 258	57%	8.71	131 / 230
adipose	100%	3898.11	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	80.00	29 / 29
spleen	100%	5548.50	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	42.36	45 / 45
ureter	0%	0	0 / 0	100%	11.88	1 / 1
blood vessel	99%	3614.08	1322 / 1335	0%	0	0 / 0
peripheral blood	99%	8662.93	918 / 929	0%	0	0 / 0
heart	74%	1001.47	640 / 861	0%	0	0 / 0
muscle	72%	899.28	578 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	14%	1.74	11 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006695	Biological process	cholesterol biosynthetic process
GO_0030223	Biological process	neutrophil differentiation
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0031965	Cellular component	nuclear membrane
GO_0005637	Cellular component	nuclear inner membrane
GO_0005635	Cellular component	nuclear envelope
GO_0016020	Cellular component	membrane
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0005521	Molecular function	lamin binding
GO_0070087	Molecular function	chromo shadow domain binding
GO_0070402	Molecular function	NADPH binding
GO_0050613	Molecular function	delta14-sterol reductase activity
GO_0005515	Molecular function	protein binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	LBR
Protein name	Delta(14)-sterol reductase LBR (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (C-14 sterol reductase) (Integral nuclear envelope inner membrane protein) (Lamin-B receptor) (Sterol C14-reductase) Delta(14)-sterol reductase LBR (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (C-14 sterol reductase) (C14SR) (Integral nuclear envelope inner membrane protein) (LMN2R) (Lamin-B receptor) (Sterol C14-reductase) Lamin B receptor
Synonyms
Description	FUNCTION: Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis . Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (By similarity). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (By similarity). Anchors the lamina and the heterochromatin to the inner nuclear membrane . .
Accessions	ENST00000272163.9 C9JES9 C9JXK0 ENST00000425080.1 A0A494C1L1 ENST00000651341.1 Q14739 ENST00000421383.1 ENST00000338179.6

LBR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review