HCST | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	46 studies	75% ± 22%	Explore
CD8-positive, alpha-beta T cell	39 studies	70% ± 19%	Explore
macrophage	37 studies	49% ± 21%	Explore
T cell	35 studies	53% ± 21%	Explore
CD4-positive, alpha-beta T cell	30 studies	55% ± 14%	Explore
classical monocyte	27 studies	65% ± 15%	Explore
conventional dendritic cell	27 studies	49% ± 15%	Explore
regulatory T cell	27 studies	55% ± 15%	Explore
plasmacytoid dendritic cell	25 studies	59% ± 17%	Explore
non-classical monocyte	24 studies	59% ± 13%	Explore
mature NK T cell	22 studies	81% ± 13%	Explore
monocyte	20 studies	59% ± 19%	Explore
gamma-delta T cell	20 studies	77% ± 15%	Explore
dendritic cell	19 studies	41% ± 16%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	49% ± 16%	Explore
B cell	16 studies	21% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	79% ± 20%	Explore
mucosal invariant T cell	16 studies	75% ± 19%	Explore
mast cell	15 studies	32% ± 16%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	84% ± 14%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	76% ± 15%	Explore
myeloid cell	13 studies	54% ± 20%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	73% ± 24%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	60% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	75% ± 19%	Explore
innate lymphoid cell	9 studies	55% ± 22%	Explore
plasma cell	9 studies	39% ± 12%	Explore
leukocyte	9 studies	49% ± 16%	Explore
T follicular helper cell	9 studies	51% ± 12%	Explore
memory B cell	9 studies	20% ± 4%	Explore
platelet	8 studies	42% ± 17%	Explore
neutrophil	8 studies	53% ± 20%	Explore
plasmablast	7 studies	50% ± 17%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	77% ± 17%	Explore
hematopoietic stem cell	7 studies	26% ± 11%	Explore
CD4-positive helper T cell	6 studies	44% ± 14%	Explore
hematopoietic precursor cell	6 studies	50% ± 24%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	66% ± 19%	Explore
mononuclear phagocyte	6 studies	56% ± 19%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	63% ± 8%	Explore
alveolar macrophage	5 studies	36% ± 11%	Explore
CD4-positive, alpha-beta cytotoxic T cell	5 studies	72% ± 24%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	77% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	80% ± 13%	Explore
exhausted T cell	5 studies	88% ± 5%	Explore
T-helper 17 cell	5 studies	60% ± 11%	Explore
microglial cell	5 studies	68% ± 18%	Explore
double negative thymocyte	5 studies	74% ± 23%	Explore
intermediate monocyte	5 studies	70% ± 18%	Explore
megakaryocyte	4 studies	41% ± 16%	Explore
precursor B cell	4 studies	22% ± 3%	Explore
granulocyte	4 studies	44% ± 13%	Explore
group 3 innate lymphoid cell	4 studies	40% ± 14%	Explore
T-helper 1 cell	4 studies	66% ± 9%	Explore
monocyte-derived dendritic cell	3 studies	62% ± 19%	Explore
common myeloid progenitor	3 studies	45% ± 11%	Explore
intraepithelial lymphocyte	3 studies	80% ± 5%	Explore
granulocyte monocyte progenitor cell	3 studies	45% ± 27%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	49% ± 4%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	66% ± 6%	Explore
double-positive, alpha-beta thymocyte	3 studies	65% ± 18%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	62% ± 13%	Explore
lung	10 studies	33% ± 11%	Explore
bone marrow	5 studies	42% ± 24%	Explore
intestine	4 studies	25% ± 8%	Explore
lymph node	4 studies	33% ± 8%	Explore
kidney	3 studies	48% ± 22%	Explore
brain	3 studies	43% ± 19%	Explore
liver	3 studies	55% ± 19%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	215.46	578 / 578	76%	5.23	874 / 1155
intestine	94%	77.34	907 / 966	62%	5.71	327 / 527
breast	90%	75.37	414 / 459	64%	3.88	718 / 1118
uterus	86%	43.78	147 / 170	68%	4.82	311 / 459
ovary	52%	23.41	93 / 180	99%	16.81	425 / 430
stomach	75%	39.92	271 / 359	74%	9.94	211 / 286
kidney	72%	52.62	64 / 89	71%	4.64	644 / 901
esophagus	61%	28.32	880 / 1445	80%	6.55	147 / 183
bladder	81%	68.05	17 / 21	56%	4.79	281 / 504
thymus	79%	45.88	513 / 653	57%	7.05	347 / 605
brain	65%	41.74	1710 / 2642	63%	4.45	443 / 705
prostate	88%	54.69	215 / 245	38%	1.62	191 / 502
adrenal gland	86%	48.07	221 / 258	38%	1.70	88 / 230
liver	70%	34.40	159 / 226	50%	3.36	202 / 406
skin	46%	20.98	835 / 1809	68%	5.67	321 / 472
pancreas	25%	10.65	81 / 328	83%	5.31	148 / 178
lymph node	0%	0	0 / 0	100%	67.76	29 / 29
peripheral blood	100%	944.41	929 / 929	0%	0	0 / 0
spleen	100%	591.39	241 / 241	0%	0	0 / 0
adipose	99%	141.08	1186 / 1204	0%	0	0 / 0
blood vessel	84%	74.56	1128 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	76%	5.71	34 / 45
heart	44%	19.39	382 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	31%	1.46	25 / 80
muscle	9%	2.83	70 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0051897	Biological process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0006468	Biological process	protein phosphorylation
GO_0050776	Biological process	regulation of immune response
GO_0042267	Biological process	natural killer cell mediated cytotoxicity
GO_0009986	Cellular component	cell surface
GO_0005886	Cellular component	plasma membrane
GO_0030674	Molecular function	protein-macromolecule adaptor activity
GO_0043548	Molecular function	phosphatidylinositol 3-kinase binding
GO_0005102	Molecular function	signaling receptor binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	HCST
Protein name	Hematopoietic cell signal transducer (DNAX-activation protein 10) (Membrane protein DAP10) (Transmembrane adapter protein KAP10)
Synonyms	DAP10 PIK3AP UNQ587/PRO1157 KAP10
Description	FUNCTION: Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as a docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells. In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR-induced signals. KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells; indeed, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells. .
Accessions	ENST00000246551.9 [Q9UBK5-1] Q9UBK5 ENST00000437550.2 [Q9UBK5-2]

HCST report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review