GTF2I | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	37 studies	35% ± 13%	Explore
fibroblast	27 studies	30% ± 10%	Explore
macrophage	26 studies	26% ± 11%	Explore
B cell	23 studies	27% ± 8%	Explore
pericyte	23 studies	27% ± 8%	Explore
smooth muscle cell	22 studies	30% ± 12%	Explore
natural killer cell	19 studies	23% ± 6%	Explore
astrocyte	18 studies	42% ± 16%	Explore
ciliated cell	17 studies	59% ± 18%	Explore
endothelial cell of lymphatic vessel	16 studies	35% ± 10%	Explore
memory B cell	16 studies	21% ± 6%	Explore
basal cell	16 studies	40% ± 21%	Explore
epithelial cell	16 studies	40% ± 21%	Explore
naive B cell	15 studies	25% ± 6%	Explore
oligodendrocyte precursor cell	14 studies	51% ± 19%	Explore
mast cell	13 studies	24% ± 12%	Explore
classical monocyte	13 studies	29% ± 14%	Explore
oligodendrocyte	13 studies	46% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	22% ± 6%	Explore
microglial cell	13 studies	37% ± 12%	Explore
T cell	12 studies	24% ± 9%	Explore
CD8-positive, alpha-beta T cell	12 studies	22% ± 7%	Explore
plasmacytoid dendritic cell	11 studies	33% ± 12%	Explore
type I pneumocyte	10 studies	49% ± 15%	Explore
club cell	10 studies	36% ± 18%	Explore
glutamatergic neuron	10 studies	60% ± 18%	Explore
conventional dendritic cell	10 studies	30% ± 17%	Explore
capillary endothelial cell	10 studies	29% ± 8%	Explore
gamma-delta T cell	10 studies	25% ± 16%	Explore
adipocyte	10 studies	56% ± 12%	Explore
type II pneumocyte	9 studies	40% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	25% ± 6%	Explore
GABAergic neuron	9 studies	57% ± 18%	Explore
CD4-positive, alpha-beta T cell	9 studies	21% ± 7%	Explore
myofibroblast cell	9 studies	38% ± 13%	Explore
connective tissue cell	9 studies	35% ± 13%	Explore
vein endothelial cell	9 studies	31% ± 10%	Explore
myeloid cell	9 studies	31% ± 10%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	22% ± 4%	Explore
secretory cell	8 studies	34% ± 15%	Explore
progenitor cell	8 studies	38% ± 13%	Explore
abnormal cell	8 studies	38% ± 18%	Explore
neuron	8 studies	50% ± 19%	Explore
endothelial cell of artery	8 studies	30% ± 9%	Explore
mesothelial cell	8 studies	37% ± 9%	Explore
respiratory goblet cell	7 studies	32% ± 18%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	23% ± 5%	Explore
kidney loop of Henle epithelial cell	7 studies	29% ± 11%	Explore
monocyte	7 studies	22% ± 10%	Explore
amacrine cell	7 studies	45% ± 15%	Explore
precursor B cell	7 studies	38% ± 14%	Explore
retinal cone cell	7 studies	37% ± 15%	Explore
dendritic cell	7 studies	32% ± 16%	Explore
endothelial cell of vascular tree	7 studies	24% ± 9%	Explore
alveolar macrophage	6 studies	32% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	25% ± 6%	Explore
kidney distal convoluted tubule epithelial cell	6 studies	39% ± 11%	Explore
retinal rod cell	6 studies	33% ± 12%	Explore
interneuron	6 studies	62% ± 21%	Explore
retinal ganglion cell	6 studies	66% ± 23%	Explore
hematopoietic stem cell	6 studies	42% ± 20%	Explore
retina horizontal cell	6 studies	52% ± 22%	Explore
regulatory T cell	6 studies	19% ± 5%	Explore
hematopoietic precursor cell	5 studies	49% ± 11%	Explore
plasma cell	5 studies	32% ± 13%	Explore
leukocyte	5 studies	26% ± 5%	Explore
non-classical monocyte	5 studies	24% ± 9%	Explore
mature NK T cell	5 studies	25% ± 8%	Explore
epithelial cell of proximal tubule	5 studies	31% ± 8%	Explore
retinal bipolar neuron	5 studies	39% ± 15%	Explore
lymphocyte	5 studies	30% ± 9%	Explore
mucosal invariant T cell	5 studies	20% ± 4%	Explore
pro-B cell	5 studies	37% ± 15%	Explore
immature B cell	5 studies	35% ± 13%	Explore
cardiac muscle cell	5 studies	41% ± 4%	Explore
Mueller cell	5 studies	42% ± 17%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	23% ± 7%	Explore
deuterosomal cell	4 studies	28% ± 7%	Explore
duct epithelial cell	4 studies	29% ± 18%	Explore
ionocyte	4 studies	38% ± 13%	Explore
precursor cell	4 studies	48% ± 16%	Explore
podocyte	4 studies	36% ± 11%	Explore
enterocyte	4 studies	18% ± 2%	Explore
goblet cell	4 studies	25% ± 10%	Explore
glial cell	4 studies	35% ± 8%	Explore
granule cell	4 studies	38% ± 16%	Explore
brush cell	4 studies	45% ± 23%	Explore
OFF-bipolar cell	4 studies	61% ± 5%	Explore
ON-bipolar cell	4 studies	68% ± 5%	Explore
innate lymphoid cell	4 studies	20% ± 4%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	33% ± 9%	Explore
luminal cell of prostate epithelium	4 studies	29% ± 12%	Explore
muscle cell	4 studies	34% ± 15%	Explore
erythrocyte	4 studies	45% ± 11%	Explore
mucus secreting cell	4 studies	37% ± 12%	Explore
renal principal cell	4 studies	32% ± 10%	Explore
squamous epithelial cell	3 studies	50% ± 23%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	32% ± 7%	Explore
cholangiocyte	3 studies	49% ± 24%	Explore
glomerular endothelial cell	3 studies	36% ± 4%	Explore
renal alpha-intercalated cell	3 studies	31% ± 4%	Explore
enteroendocrine cell	3 studies	41% ± 8%	Explore
neural crest cell	3 studies	45% ± 9%	Explore
GABAergic interneuron	3 studies	64% ± 12%	Explore
placental villous trophoblast	3 studies	39% ± 12%	Explore
mononuclear phagocyte	3 studies	20% ± 3%	Explore
GABAergic amacrine cell	3 studies	60% ± 11%	Explore
glycinergic amacrine cell	3 studies	50% ± 7%	Explore
rod bipolar cell	3 studies	67% ± 8%	Explore
germinal center B cell	3 studies	29% ± 6%	Explore
myoepithelial cell	3 studies	42% ± 19%	Explore
retinal pigment epithelial cell	3 studies	37% ± 14%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	69% ± 8%	Explore
neutrophil	3 studies	23% ± 3%	Explore
group 3 innate lymphoid cell	3 studies	35% ± 17%	Explore
transit amplifying cell	3 studies	37% ± 31%	Explore
parietal epithelial cell	3 studies	43% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	17 studies	48% ± 19%	Explore
lung	13 studies	37% ± 18%	Explore
eye	9 studies	39% ± 15%	Explore
peripheral blood	8 studies	29% ± 13%	Explore
kidney	8 studies	28% ± 10%	Explore
heart	5 studies	32% ± 3%	Explore
intestine	4 studies	29% ± 9%	Explore
bone marrow	4 studies	33% ± 16%	Explore
breast	4 studies	24% ± 5%	Explore
adipose	4 studies	36% ± 20%	Explore
placenta	3 studies	24% ± 7%	Explore
uterus	3 studies	40% ± 17%	Explore
liver	3 studies	41% ± 21%	Explore
lymph node	3 studies	28% ± 16%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	2047.76	180 / 180	100%	13.60	428 / 430
esophagus	99%	1752.94	1435 / 1445	100%	16.21	183 / 183
stomach	99%	1638.49	357 / 359	99%	11.03	282 / 286
intestine	100%	1700.81	964 / 966	97%	7.63	513 / 527
lung	99%	1471.34	575 / 578	97%	8.33	1121 / 1155
breast	100%	1964.49	459 / 459	95%	10.29	1061 / 1118
brain	97%	1214.25	2557 / 2642	97%	10.95	686 / 705
skin	100%	2326.36	1806 / 1809	93%	7.76	437 / 472
thymus	100%	2986.92	652 / 653	91%	9.53	550 / 605
bladder	100%	1897.38	21 / 21	90%	6.13	455 / 504
pancreas	98%	1012.74	322 / 328	91%	5.92	162 / 178
prostate	100%	1364.45	245 / 245	87%	6.65	437 / 502
kidney	100%	1216.03	89 / 89	86%	6.87	779 / 901
uterus	100%	1777.95	170 / 170	80%	5.18	369 / 459
adrenal gland	100%	3091.05	258 / 258	75%	5.42	173 / 230
liver	82%	588.98	186 / 226	59%	2.79	238 / 406
adipose	100%	1809.06	1204 / 1204	0%	0	0 / 0
spleen	100%	1191.27	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	2.21	1 / 1
muscle	100%	2071.25	802 / 803	0%	0	0 / 0
blood vessel	100%	1309.20	1332 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	89%	6.11	40 / 45
eye	0%	0	0 / 0	89%	4.44	71 / 80
heart	88%	1036.64	758 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	59%	3.83	17 / 29
peripheral blood	46%	956.16	429 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006366	Biological process	transcription by RNA polymerase II
GO_0016525	Biological process	negative regulation of angiogenesis
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0005654	Cellular component	nucleoplasm
GO_0016020	Cellular component	membrane
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0061629	Molecular function	RNA polymerase II-specific DNA-binding transcription factor binding
GO_0003677	Molecular function	DNA binding
GO_0001228	Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific
GO_0003700	Molecular function	DNA-binding transcription factor activity
GO_0005515	Molecular function	protein binding
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific

IV. Literature review

[source]

Gene name	GTF2I
Protein name	General transcription factor II, i General transcription factor II-I General transcription factor IIi isoform B General transcription factor IIi isoform D General transcription factor IIi isoform E General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) General transcription factor IIi isoform A GTF2I-BRAF fusion protein General transcription factor IIi isoform C General transcription factor IIi
Synonyms	BRAF fusion WBSCR6 BAP135
Description	FUNCTION: Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. .
Accessions	ENST00000432143.2 A0A494C1K3 A0A8I5KVB5 X5D939 A0A494C013 A0A494C0Q7 ENST00000573035.6 [P78347-1] C9J6M0 ENST00000690345.1 X5D2J9 X5DR09 P78347 ENST00000621734.4 [P78347-4] ENST00000652150.1 A0A1W6S962 ENST00000620631.4 Q499G6 ENST00000443166.5 [P78347-5] ENST00000614986.4 [P78347-3] ENST00000650807.1 A0A8F9S2Z6 X5DNP5 X5D7Q9 ENST00000620879.4 [P78347-2]

GTF2I report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review