FAM162A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0090200Biological processpositive regulation of release of cytochrome c from mitochondria
GO_0051402Biological processneuron apoptotic process
GO_0006919Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0043065Biological processpositive regulation of apoptotic process
GO_0071456Biological processcellular response to hypoxia
GO_0031966Cellular componentmitochondrial membrane
GO_0005829Cellular componentcytosol
GO_0005739Cellular componentmitochondrion
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFAM162A
Protein nameFamily with sequence similarity 162 member A
Protein FAM162A (E2-induced gene 5 protein) (Growth and transformation-dependent protein) (HGTD-P)
Protein FAM162A
SynonymsC3orf28
E2IG5
FWP001
DC16
DescriptionFUNCTION: Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues . May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition . May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly (By similarity). .

AccessionsENST00000689215.1
A0A8I5KQT5
F8W7Q4
ENST00000232125.9
ENST00000688794.1
A0A8I5KUT6
E9PH05
ENST00000684791.1
ENST00000686831.1
ENST00000692876.1
ENST00000688900.1
A0A8I5KW67
ENST00000477892.5
Q96A26
ENST00000469967.1
ENST00000685650.1
ENST00000693245.1
A0A8I5QJA3
A0A8I5KUL7