ESD | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	34 studies	41% ± 16%	Explore
endothelial cell	29 studies	31% ± 15%	Explore
smooth muscle cell	25 studies	45% ± 15%	Explore
pericyte	25 studies	42% ± 17%	Explore
CD4-positive, alpha-beta T cell	23 studies	23% ± 8%	Explore
macrophage	19 studies	25% ± 10%	Explore
conventional dendritic cell	18 studies	31% ± 15%	Explore
connective tissue cell	16 studies	45% ± 16%	Explore
endothelial cell of lymphatic vessel	15 studies	38% ± 10%	Explore
basal cell	15 studies	34% ± 16%	Explore
B cell	15 studies	26% ± 10%	Explore
plasmacytoid dendritic cell	15 studies	29% ± 12%	Explore
classical monocyte	14 studies	25% ± 11%	Explore
epithelial cell	14 studies	40% ± 21%	Explore
myofibroblast cell	13 studies	49% ± 14%	Explore
mast cell	12 studies	23% ± 3%	Explore
monocyte	12 studies	25% ± 8%	Explore
CD8-positive, alpha-beta T cell	12 studies	21% ± 8%	Explore
T cell	12 studies	24% ± 13%	Explore
ciliated cell	11 studies	36% ± 15%	Explore
regulatory T cell	11 studies	21% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	22% ± 5%	Explore
capillary endothelial cell	10 studies	23% ± 5%	Explore
progenitor cell	9 studies	44% ± 12%	Explore
abnormal cell	9 studies	28% ± 13%	Explore
endothelial cell of artery	9 studies	21% ± 5%	Explore
endothelial cell of vascular tree	9 studies	31% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	23% ± 8%	Explore
non-classical monocyte	8 studies	27% ± 10%	Explore
natural killer cell	8 studies	22% ± 7%	Explore
astrocyte	8 studies	30% ± 13%	Explore
naive B cell	7 studies	19% ± 5%	Explore
epithelial cell of proximal tubule	7 studies	43% ± 13%	Explore
mesothelial cell	7 studies	46% ± 20%	Explore
vein endothelial cell	7 studies	25% ± 7%	Explore
memory B cell	7 studies	21% ± 3%	Explore
hematopoietic stem cell	7 studies	35% ± 12%	Explore
neuron	7 studies	44% ± 20%	Explore
T follicular helper cell	7 studies	20% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	19% ± 4%	Explore
kidney loop of Henle epithelial cell	6 studies	30% ± 7%	Explore
goblet cell	6 studies	27% ± 16%	Explore
type II pneumocyte	6 studies	37% ± 16%	Explore
dendritic cell	6 studies	35% ± 22%	Explore
secretory cell	6 studies	26% ± 10%	Explore
mononuclear phagocyte	5 studies	30% ± 15%	Explore
renal alpha-intercalated cell	5 studies	52% ± 9%	Explore
enterocyte	5 studies	26% ± 10%	Explore
intestinal crypt stem cell	5 studies	36% ± 7%	Explore
transit amplifying cell	5 studies	25% ± 9%	Explore
retinal rod cell	5 studies	31% ± 16%	Explore
pro-B cell	5 studies	44% ± 5%	Explore
myeloid cell	5 studies	29% ± 14%	Explore
type I pneumocyte	5 studies	30% ± 11%	Explore
glutamatergic neuron	5 studies	31% ± 12%	Explore
oligodendrocyte precursor cell	5 studies	29% ± 12%	Explore
oligodendrocyte	5 studies	20% ± 5%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	23% ± 5%	Explore
hematopoietic precursor cell	4 studies	59% ± 21%	Explore
pancreatic A cell	4 studies	46% ± 17%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	50% ± 13%	Explore
enteroendocrine cell	4 studies	46% ± 17%	Explore
leukocyte	4 studies	26% ± 6%	Explore
erythroblast	4 studies	51% ± 15%	Explore
immature B cell	4 studies	33% ± 24%	Explore
precursor B cell	4 studies	36% ± 19%	Explore
adventitial cell	4 studies	34% ± 11%	Explore
Mueller cell	4 studies	37% ± 14%	Explore
erythrocyte	4 studies	37% ± 20%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	25% ± 3%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	22% ± 7%	Explore
pancreatic D cell	3 studies	44% ± 20%	Explore
type B pancreatic cell	3 studies	58% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	20% ± 3%	Explore
glomerular endothelial cell	3 studies	25% ± 5%	Explore
mature NK T cell	3 studies	17% ± 1%	Explore
neural crest cell	3 studies	54% ± 10%	Explore
lymphocyte	3 studies	29% ± 9%	Explore
innate lymphoid cell	3 studies	21% ± 2%	Explore
plasma cell	3 studies	28% ± 8%	Explore
club cell	3 studies	29% ± 10%	Explore
retinal cone cell	3 studies	46% ± 12%	Explore
microglial cell	3 studies	24% ± 8%	Explore
alveolar macrophage	3 studies	28% ± 4%	Explore
rod bipolar cell	3 studies	26% ± 7%	Explore
muscle cell	3 studies	41% ± 22%	Explore
germinal center B cell	3 studies	22% ± 2%	Explore
myoepithelial cell	3 studies	38% ± 8%	Explore
GABAergic neuron	3 studies	28% ± 2%	Explore
pancreatic ductal cell	3 studies	50% ± 20%	Explore
granulocyte	3 studies	36% ± 10%	Explore
granulocyte monocyte progenitor cell	3 studies	39% ± 23%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	51% ± 25%	Explore
glial cell	3 studies	44% ± 26%	Explore
group 3 innate lymphoid cell	3 studies	29% ± 14%	Explore
keratinocyte	3 studies	21% ± 1%	Explore
T-helper 17 cell	3 studies	27% ± 9%	Explore
gamma-delta T cell	3 studies	36% ± 29%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	26% ± 2%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	22% ± 1%	Explore
interneuron	3 studies	25% ± 8%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	25% ± 1%	Explore
progenitor cell of mammary luminal epithelium	3 studies	29% ± 4%	Explore
hepatocyte	3 studies	41% ± 31%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	13 studies	31% ± 15%	Explore
peripheral blood	11 studies	25% ± 10%	Explore
intestine	9 studies	33% ± 18%	Explore
eye	9 studies	27% ± 13%	Explore
brain	9 studies	24% ± 7%	Explore
kidney	8 studies	31% ± 10%	Explore
liver	5 studies	30% ± 23%	Explore
lymph node	5 studies	20% ± 4%	Explore
uterus	4 studies	41% ± 13%	Explore
bone marrow	4 studies	22% ± 4%	Explore
breast	4 studies	24% ± 6%	Explore
pancreas	3 studies	55% ± 9%	Explore
adrenal gland	3 studies	18% ± 2%	Explore
esophagus	3 studies	39% ± 31%	Explore
thymus	3 studies	56% ± 25%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	5512.49	1445 / 1445	100%	62.60	183 / 183
skin	100%	5271.32	1809 / 1809	100%	89.56	472 / 472
kidney	100%	4896.35	89 / 89	100%	100.97	900 / 901
thymus	100%	5834.09	653 / 653	100%	103.95	604 / 605
breast	100%	6053.24	459 / 459	100%	79.65	1116 / 1118
prostate	100%	4621.02	245 / 245	100%	76.18	501 / 502
uterus	100%	6823.01	170 / 170	100%	72.05	458 / 459
ovary	100%	6244.07	180 / 180	100%	55.17	429 / 430
intestine	100%	5563.22	966 / 966	100%	100.25	525 / 527
brain	99%	3364.63	2626 / 2642	100%	95.63	705 / 705
liver	100%	3695.96	225 / 226	100%	71.35	405 / 406
lung	99%	4383.20	575 / 578	100%	62.95	1151 / 1155
stomach	100%	3780.34	359 / 359	99%	88.24	283 / 286
bladder	100%	5768.71	21 / 21	98%	72.13	495 / 504
adrenal gland	100%	4120.86	258 / 258	98%	78.84	225 / 230
pancreas	95%	1972.13	311 / 328	100%	71.18	178 / 178
blood vessel	100%	10629.61	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	78.59	80 / 80
lymph node	0%	0	0 / 0	100%	91.61	29 / 29
spleen	100%	3133.35	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	58.26	45 / 45
ureter	0%	0	0 / 0	100%	21.90	1 / 1
adipose	100%	6333.09	1203 / 1204	0%	0	0 / 0
muscle	100%	4232.27	802 / 803	0%	0	0 / 0
heart	96%	4243.53	827 / 861	0%	0	0 / 0
peripheral blood	83%	2691.00	771 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0008150	Biological process	biological_process
GO_0046294	Biological process	formaldehyde catabolic process
GO_0005788	Cellular component	endoplasmic reticulum lumen
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0047374	Molecular function	methylumbelliferyl-acetate deacetylase activity
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding
GO_0052689	Molecular function	carboxylic ester hydrolase activity
GO_0018738	Molecular function	S-formylglutathione hydrolase activity
GO_0016788	Molecular function	hydrolase activity, acting on ester bonds

IV. Literature review

[source]

Gene name	ESD
Protein name	S-formylglutathione hydrolase (FGH) (EC 3.1.2.12) (Esterase D) (Methylumbelliferyl-acetate deacetylase) (EC 3.1.1.56) S-formylglutathione hydrolase (EC 3.1.2.12)
Synonyms	hCG_29992
Description	FUNCTION: Serine hydrolase involved in the detoxification of formaldehyde. . FUNCTION: Serine hydrolase involved in the detoxification of formaldehyde. . FUNCTION: Serine hydrolase involved in the detoxification of formaldehyde. . FUNCTION: Serine hydrolase involved in the detoxification of formaldehyde. . FUNCTION: Serine hydrolase involved in the detoxification of formaldehyde. .
Accessions	ENST00000471867.3 ENST00000412582.5 ENST00000378697.5 P10768 H7BZT7 U3KQT1 A0A140VJJ2 ENST00000378720.8 X6RA14

ESD report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review