EIF4A3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035640Biological processexploration behavior
GO_1990416Biological processcellular response to brain-derived neurotrophic factor stimulus
GO_0099578Biological processregulation of translation at postsynapse, modulating synaptic transmission
GO_0014070Biological processresponse to organic cyclic compound
GO_0008306Biological processassociative learning
GO_0000184Biological processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO_0000398Biological processmRNA splicing, via spliceosome
GO_0006406Biological processmRNA export from nucleus
GO_2000622Biological processregulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO_0072715Biological processcellular response to selenite ion
GO_0090394Biological processnegative regulation of excitatory postsynaptic potential
GO_0045727Biological processpositive regulation of translation
GO_0048701Biological processembryonic cranial skeleton morphogenesis
GO_0006364Biological processrRNA processing
GO_1904570Biological processnegative regulation of selenocysteine incorporation
GO_0017148Biological processnegative regulation of translation
GO_0098978Cellular componentglutamatergic synapse
GO_0005730Cellular componentnucleolus
GO_0016020Cellular componentmembrane
GO_0016607Cellular componentnuclear speck
GO_0035145Cellular componentexon-exon junction complex
GO_0005654Cellular componentnucleoplasm
GO_0098794Cellular componentpostsynapse
GO_0043025Cellular componentneuronal cell body
GO_0030425Cellular componentdendrite
GO_0005829Cellular componentcytosol
GO_0071006Cellular componentU2-type catalytic step 1 spliceosome
GO_0005737Cellular componentcytoplasm
GO_0071013Cellular componentcatalytic step 2 spliceosome
GO_0005634Cellular componentnucleus
GO_0008143Molecular functionpoly(A) binding
GO_0003724Molecular functionRNA helicase activity
GO_0043021Molecular functionribonucleoprotein complex binding
GO_0003729Molecular functionmRNA binding
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0035368Molecular functionselenocysteine insertion sequence binding
GO_0035613Molecular functionRNA stem-loop binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameEIF4A3
Protein nameEukaryotic initiation factor 4A-III (eIF-4A-III) (eIF4A-III) (EC 3.6.4.13) (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Eukaryotic translation initiation factor 4A isoform 3) (Nuclear matrix protein 265) (NMP 265) (hNMP 265) [Cleaved into: Eukaryotic initiation factor 4A-III, N-terminally processed]
Eukaryotic initiation factor 4A-III (EC 3.6.4.13) (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic translation initiation factor 4A isoform 3)
SynonymsDDX48
KIAA0111
DescriptionFUNCTION: ATP-dependent RNA helicase . Involved in pre-mRNA splicing as component of the spliceosome . Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs . The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly . Involved in craniofacial development . .

AccessionsP38919
ENST00000647795.1
ENST00000707787.1
I3L3H2
ENST00000649764.2
ENST00000707791.1
ENST00000576547.2