EIF2A | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	23 studies	21% ± 6%	Explore
CD4-positive, alpha-beta T cell	21 studies	24% ± 7%	Explore
natural killer cell	19 studies	20% ± 5%	Explore
endothelial cell	19 studies	24% ± 8%	Explore
CD8-positive, alpha-beta T cell	18 studies	22% ± 7%	Explore
conventional dendritic cell	17 studies	25% ± 14%	Explore
fibroblast	16 studies	22% ± 8%	Explore
pericyte	16 studies	22% ± 4%	Explore
regulatory T cell	16 studies	21% ± 5%	Explore
naive B cell	15 studies	21% ± 4%	Explore
memory B cell	14 studies	20% ± 3%	Explore
basal cell	14 studies	26% ± 11%	Explore
T cell	13 studies	21% ± 6%	Explore
classical monocyte	12 studies	24% ± 9%	Explore
connective tissue cell	12 studies	20% ± 3%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	25% ± 7%	Explore
gamma-delta T cell	11 studies	25% ± 14%	Explore
mast cell	10 studies	22% ± 4%	Explore
monocyte	10 studies	19% ± 3%	Explore
smooth muscle cell	10 studies	22% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	28% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	21% ± 3%	Explore
plasmacytoid dendritic cell	10 studies	27% ± 8%	Explore
non-classical monocyte	9 studies	27% ± 11%	Explore
mucosal invariant T cell	9 studies	24% ± 5%	Explore
endothelial cell of vascular tree	9 studies	23% ± 4%	Explore
epithelial cell	9 studies	36% ± 19%	Explore
macrophage	9 studies	21% ± 6%	Explore
plasma cell	8 studies	32% ± 11%	Explore
endothelial cell of lymphatic vessel	7 studies	25% ± 8%	Explore
myofibroblast cell	7 studies	21% ± 3%	Explore
mature NK T cell	7 studies	19% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	25% ± 6%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	25% ± 6%	Explore
hematopoietic precursor cell	6 studies	27% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	23% ± 7%	Explore
dendritic cell	6 studies	37% ± 21%	Explore
plasmablast	5 studies	40% ± 19%	Explore
CD16-positive, CD56-dim natural killer cell, human	5 studies	22% ± 1%	Explore
hematopoietic stem cell	5 studies	25% ± 5%	Explore
precursor B cell	5 studies	28% ± 8%	Explore
alveolar macrophage	5 studies	20% ± 4%	Explore
secretory cell	5 studies	20% ± 4%	Explore
T follicular helper cell	5 studies	23% ± 6%	Explore
abnormal cell	5 studies	24% ± 5%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	24% ± 11%	Explore
innate lymphoid cell	5 studies	19% ± 4%	Explore
astrocyte	5 studies	21% ± 5%	Explore
oligodendrocyte precursor cell	5 studies	22% ± 6%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	19% ± 3%	Explore
endothelial cell of artery	4 studies	17% ± 2%	Explore
immature B cell	4 studies	22% ± 4%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	25% ± 4%	Explore
vein endothelial cell	4 studies	20% ± 4%	Explore
glutamatergic neuron	4 studies	39% ± 13%	Explore
goblet cell	4 studies	30% ± 11%	Explore
intestinal crypt stem cell	4 studies	23% ± 2%	Explore
neuron	4 studies	26% ± 10%	Explore
oligodendrocyte	4 studies	20% ± 1%	Explore
type B pancreatic cell	3 studies	34% ± 8%	Explore
leukocyte	3 studies	22% ± 3%	Explore
mononuclear phagocyte	3 studies	26% ± 7%	Explore
exhausted T cell	3 studies	22% ± 5%	Explore
kidney loop of Henle epithelial cell	3 studies	18% ± 2%	Explore
progenitor cell	3 studies	18% ± 3%	Explore
epithelial cell of proximal tubule	3 studies	19% ± 1%	Explore
pro-B cell	3 studies	24% ± 2%	Explore
myeloid cell	3 studies	29% ± 9%	Explore
club cell	3 studies	24% ± 3%	Explore
type II pneumocyte	3 studies	25% ± 13%	Explore
mucus secreting cell	3 studies	18% ± 2%	Explore
serous secreting cell	3 studies	21% ± 4%	Explore
ciliated cell	3 studies	27% ± 7%	Explore
lymphocyte	3 studies	22% ± 7%	Explore
germinal center B cell	3 studies	24% ± 4%	Explore
type I pneumocyte	3 studies	21% ± 8%	Explore
GABAergic neuron	3 studies	38% ± 3%	Explore
granulocyte	3 studies	23% ± 6%	Explore
granulocyte monocyte progenitor cell	3 studies	21% ± 3%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	40% ± 25%	Explore
group 3 innate lymphoid cell	3 studies	29% ± 9%	Explore
interneuron	3 studies	33% ± 14%	Explore
double negative thymocyte	3 studies	35% ± 17%	Explore
progenitor cell of mammary luminal epithelium	3 studies	28% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	14 studies	25% ± 7%	Explore
lung	7 studies	25% ± 4%	Explore
intestine	6 studies	21% ± 8%	Explore
brain	6 studies	28% ± 11%	Explore
kidney	4 studies	17% ± 1%	Explore
bone marrow	4 studies	17% ± 1%	Explore
uterus	4 studies	24% ± 10%	Explore
breast	4 studies	18% ± 3%	Explore
liver	4 studies	26% ± 13%	Explore
pancreas	3 studies	29% ± 7%	Explore
eye	3 studies	24% ± 2%	Explore
lymph node	3 studies	24% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	4436.52	21 / 21	100%	54.10	504 / 504
breast	100%	5334.02	459 / 459	100%	66.13	1118 / 1118
esophagus	100%	3882.71	1445 / 1445	100%	68.27	183 / 183
ovary	100%	5274.66	180 / 180	100%	54.28	430 / 430
pancreas	100%	4762.91	328 / 328	100%	46.74	178 / 178
prostate	100%	4067.15	245 / 245	100%	68.28	502 / 502
uterus	100%	4664.23	170 / 170	100%	55.31	459 / 459
lung	100%	4243.89	577 / 578	100%	63.34	1155 / 1155
intestine	100%	4168.22	966 / 966	100%	63.49	526 / 527
stomach	100%	4103.33	359 / 359	100%	62.73	285 / 286
kidney	100%	3641.78	89 / 89	100%	53.22	897 / 901
liver	100%	2464.15	226 / 226	100%	34.81	404 / 406
thymus	100%	4197.34	653 / 653	99%	59.09	600 / 605
adrenal gland	100%	3784.80	258 / 258	99%	40.03	228 / 230
skin	100%	5325.22	1809 / 1809	96%	50.92	455 / 472
brain	96%	2349.40	2545 / 2642	100%	45.22	705 / 705
adipose	100%	5363.10	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	49.62	29 / 29
muscle	100%	5195.58	803 / 803	0%	0	0 / 0
spleen	100%	3801.40	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	60.53	45 / 45
ureter	0%	0	0 / 0	100%	20.53	1 / 1
blood vessel	100%	5018.12	1334 / 1335	0%	0	0 / 0
heart	96%	3118.61	829 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	91%	37.11	73 / 80
peripheral blood	88%	3444.16	814 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0009967	Biological process	positive regulation of signal transduction
GO_0032933	Biological process	SREBP signaling pathway
GO_0006413	Biological process	translational initiation
GO_0042255	Biological process	ribosome assembly
GO_1990928	Biological process	response to amino acid starvation
GO_0006417	Biological process	regulation of translation
GO_0005615	Cellular component	extracellular space
GO_0072562	Cellular component	blood microparticle
GO_0005850	Cellular component	eukaryotic translation initiation factor 2 complex
GO_0022627	Cellular component	cytosolic small ribosomal subunit
GO_0005737	Cellular component	cytoplasm
GO_0043022	Molecular function	ribosome binding
GO_0003743	Molecular function	translation initiation factor activity
GO_0045296	Molecular function	cadherin binding
GO_0000049	Molecular function	tRNA binding
GO_0005515	Molecular function	protein binding
GO_0003729	Molecular function	mRNA binding

IV. Literature review

[source]

Gene name	EIF2A
Protein name	Eukaryotic translation initiation factor 2A (eIF-2A) Eukaryotic translation initiation factor 2A (eIF-2A) (65 kDa eukaryotic translation initiation factor 2A) [Cleaved into: Eukaryotic translation initiation factor 2A, N-terminally processed] Eukaryotic translation initiation factor 2A
Synonyms	CDA02 MSTP089 MSTP004
Description	FUNCTION: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. . FUNCTION: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. . FUNCTION: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. .
Accessions	F8WAT3 F8WAE5 ENST00000273435.9 Q9BY44 ENST00000487799.5 [Q9BY44-3] ENST00000465535.1 H7C5Q4 C9IZE1 F8WF18 H7C5R5 ENST00000477551.5 ENST00000490505.5 ENST00000462221.5 ENST00000406576.7 [Q9BY44-4] H7C5Q3 ENST00000482093.5 ENST00000460851.6 [Q9BY44-1] ENST00000494558.5

EIF2A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review