DNAJC15 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	31 studies	25% ± 8%	Explore
macrophage	28 studies	27% ± 9%	Explore
endothelial cell	28 studies	29% ± 12%	Explore
conventional dendritic cell	25 studies	37% ± 13%	Explore
fibroblast	22 studies	28% ± 12%	Explore
classical monocyte	22 studies	32% ± 11%	Explore
natural killer cell	21 studies	24% ± 9%	Explore
non-classical monocyte	19 studies	29% ± 12%	Explore
dendritic cell	18 studies	38% ± 24%	Explore
CD4-positive, alpha-beta T cell	18 studies	25% ± 9%	Explore
pericyte	18 studies	26% ± 8%	Explore
regulatory T cell	17 studies	25% ± 6%	Explore
monocyte	16 studies	28% ± 10%	Explore
memory B cell	15 studies	27% ± 6%	Explore
epithelial cell	15 studies	34% ± 21%	Explore
naive B cell	15 studies	23% ± 6%	Explore
plasmacytoid dendritic cell	14 studies	25% ± 10%	Explore
CD8-positive, alpha-beta T cell	14 studies	29% ± 8%	Explore
plasma cell	12 studies	41% ± 13%	Explore
plasmablast	11 studies	41% ± 25%	Explore
smooth muscle cell	11 studies	28% ± 7%	Explore
vein endothelial cell	11 studies	21% ± 6%	Explore
gamma-delta T cell	11 studies	25% ± 15%	Explore
T cell	10 studies	27% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	21% ± 4%	Explore
capillary endothelial cell	10 studies	20% ± 5%	Explore
type I pneumocyte	9 studies	27% ± 9%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	26% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	21% ± 4%	Explore
myofibroblast cell	9 studies	28% ± 5%	Explore
progenitor cell	9 studies	29% ± 12%	Explore
connective tissue cell	9 studies	27% ± 6%	Explore
endothelial cell of artery	9 studies	20% ± 3%	Explore
basal cell	8 studies	30% ± 16%	Explore
ciliated cell	8 studies	39% ± 20%	Explore
abnormal cell	8 studies	26% ± 5%	Explore
myeloid cell	8 studies	29% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	26% ± 7%	Explore
mature NK T cell	7 studies	20% ± 3%	Explore
epithelial cell of proximal tubule	7 studies	23% ± 4%	Explore
enterocyte	7 studies	31% ± 9%	Explore
goblet cell	7 studies	28% ± 16%	Explore
type II pneumocyte	7 studies	29% ± 15%	Explore
neuron	7 studies	30% ± 13%	Explore
alveolar macrophage	6 studies	23% ± 5%	Explore
mast cell	6 studies	18% ± 3%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	27% ± 12%	Explore
club cell	6 studies	23% ± 4%	Explore
respiratory goblet cell	6 studies	30% ± 16%	Explore
leukocyte	6 studies	23% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	21% ± 2%	Explore
mucosal invariant T cell	6 studies	18% ± 3%	Explore
secretory cell	5 studies	33% ± 18%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	30% ± 10%	Explore
mononuclear phagocyte	5 studies	29% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	25% ± 4%	Explore
enteroendocrine cell	5 studies	29% ± 7%	Explore
transit amplifying cell	5 studies	23% ± 5%	Explore
erythrocyte	5 studies	30% ± 17%	Explore
T follicular helper cell	5 studies	23% ± 3%	Explore
endothelial cell of vascular tree	5 studies	24% ± 6%	Explore
microglial cell	5 studies	22% ± 6%	Explore
hematopoietic precursor cell	4 studies	38% ± 9%	Explore
platelet	4 studies	24% ± 5%	Explore
pancreatic A cell	4 studies	34% ± 13%	Explore
exhausted T cell	4 studies	31% ± 10%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	22% ± 7%	Explore
kidney loop of Henle epithelial cell	4 studies	24% ± 10%	Explore
erythroblast	4 studies	35% ± 13%	Explore
hematopoietic stem cell	4 studies	19% ± 3%	Explore
endothelial cell of lymphatic vessel	4 studies	26% ± 7%	Explore
cardiac muscle cell	4 studies	19% ± 3%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	28% ± 9%	Explore
intermediate monocyte	4 studies	43% ± 13%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	27% ± 6%	Explore
astrocyte	4 studies	29% ± 10%	Explore
glutamatergic neuron	4 studies	38% ± 13%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	29% ± 8%	Explore
brush cell	4 studies	22% ± 6%	Explore
oligodendrocyte	4 studies	23% ± 5%	Explore
type B pancreatic cell	3 studies	43% ± 5%	Explore
renal alpha-intercalated cell	3 studies	28% ± 4%	Explore
intestinal crypt stem cell	3 studies	28% ± 10%	Explore
neural crest cell	3 studies	21% ± 3%	Explore
extravillous trophoblast	3 studies	47% ± 5%	Explore
megakaryocyte	3 studies	35% ± 12%	Explore
immature B cell	3 studies	29% ± 3%	Explore
precursor B cell	3 studies	34% ± 6%	Explore
pro-B cell	3 studies	19% ± 3%	Explore
germinal center B cell	3 studies	31% ± 5%	Explore
muscle cell	3 studies	27% ± 11%	Explore
GABAergic neuron	3 studies	37% ± 3%	Explore
pancreatic ductal cell	3 studies	47% ± 12%	Explore
innate lymphoid cell	3 studies	19% ± 0%	Explore
group 3 innate lymphoid cell	3 studies	27% ± 14%	Explore
double negative thymocyte	3 studies	36% ± 18%	Explore
hepatocyte	3 studies	41% ± 11%	Explore
oligodendrocyte precursor cell	3 studies	28% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	14 studies	26% ± 8%	Explore
lung	12 studies	28% ± 13%	Explore
kidney	9 studies	22% ± 4%	Explore
intestine	9 studies	24% ± 8%	Explore
liver	6 studies	28% ± 12%	Explore
brain	6 studies	29% ± 6%	Explore
lymph node	4 studies	23% ± 7%	Explore
pancreas	3 studies	41% ± 5%	Explore
placenta	3 studies	26% ± 9%	Explore
bone marrow	3 studies	20% ± 2%	Explore
eye	3 studies	20% ± 2%	Explore
thymus	3 studies	34% ± 13%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
intestine	100%	3048.63	966 / 966	99%	35.80	521 / 527
thymus	100%	2067.68	653 / 653	99%	21.93	597 / 605
stomach	100%	1690.04	359 / 359	98%	36.65	281 / 286
kidney	100%	2205.84	89 / 89	98%	17.41	881 / 901
brain	100%	3079.55	2640 / 2642	97%	19.47	687 / 705
breast	100%	1905.52	459 / 459	96%	18.13	1070 / 1118
adrenal gland	100%	3017.97	258 / 258	95%	18.26	219 / 230
skin	99%	1969.44	1784 / 1809	95%	17.50	450 / 472
pancreas	98%	1060.16	321 / 328	96%	21.57	170 / 178
esophagus	100%	2034.20	1443 / 1445	92%	18.03	169 / 183
lung	99%	1712.04	570 / 578	90%	16.01	1039 / 1155
liver	98%	1184.84	222 / 226	89%	9.98	361 / 406
bladder	100%	1933.10	21 / 21	85%	20.52	429 / 504
uterus	94%	1161.38	159 / 170	71%	13.83	325 / 459
prostate	96%	1182.98	235 / 245	56%	5.17	282 / 502
ovary	47%	336.63	85 / 180	59%	7.68	254 / 430
lymph node	0%	0	0 / 0	100%	23.50	29 / 29
spleen	100%	1613.34	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	6.44	1 / 1
blood vessel	100%	2121.81	1334 / 1335	0%	0	0 / 0
adipose	100%	1944.65	1202 / 1204	0%	0	0 / 0
muscle	100%	1801.10	800 / 803	0%	0	0 / 0
heart	98%	2443.72	842 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	96%	10.64	77 / 80
tonsil	0%	0	0 / 0	82%	10.00	37 / 45
peripheral blood	54%	754.58	501 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0030150	Biological process	protein import into mitochondrial matrix
GO_0031333	Biological process	negative regulation of protein-containing complex assembly
GO_0006886	Biological process	intracellular protein transport
GO_0019216	Biological process	regulation of lipid metabolic process
GO_1902957	Biological process	negative regulation of mitochondrial electron transport, NADH to ubiquinone
GO_0006120	Biological process	mitochondrial electron transport, NADH to ubiquinone
GO_0009267	Biological process	cellular response to starvation
GO_0065003	Biological process	protein-containing complex assembly
GO_0001405	Cellular component	PAM complex, Tim23 associated import motor
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0005744	Cellular component	TIM23 mitochondrial import inner membrane translocase complex
GO_0005515	Molecular function	protein binding
GO_0001671	Molecular function	ATPase activator activity

IV. Literature review

[source]

Gene name	DNAJC15
Protein name	DnaJ homolog subfamily C member 15 (Cell growth-inhibiting gene 22 protein) (Methylation-controlled J protein) (MCJ)
Synonyms	HSD18 DNAJD1 GIG22
Description	FUNCTION: Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9. .
Accessions	ENST00000379221.4 Q9Y5T4

DNAJC15 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review