DGUOK | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	32 studies	28% ± 8%	Explore
CD4-positive, alpha-beta T cell	26 studies	26% ± 9%	Explore
CD8-positive, alpha-beta T cell	26 studies	27% ± 9%	Explore
B cell	23 studies	26% ± 7%	Explore
fibroblast	23 studies	26% ± 11%	Explore
T cell	21 studies	24% ± 7%	Explore
regulatory T cell	20 studies	29% ± 8%	Explore
endothelial cell	19 studies	24% ± 10%	Explore
non-classical monocyte	18 studies	26% ± 12%	Explore
classical monocyte	17 studies	24% ± 9%	Explore
pericyte	17 studies	24% ± 8%	Explore
memory B cell	16 studies	22% ± 5%	Explore
naive B cell	16 studies	23% ± 5%	Explore
smooth muscle cell	16 studies	23% ± 7%	Explore
conventional dendritic cell	14 studies	26% ± 13%	Explore
macrophage	14 studies	22% ± 7%	Explore
mast cell	13 studies	22% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	29% ± 6%	Explore
monocyte	13 studies	23% ± 6%	Explore
mature NK T cell	13 studies	27% ± 6%	Explore
gamma-delta T cell	13 studies	30% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	25% ± 5%	Explore
basal cell	11 studies	32% ± 15%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	30% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	30% ± 7%	Explore
connective tissue cell	11 studies	30% ± 8%	Explore
epithelial cell	11 studies	37% ± 20%	Explore
plasma cell	10 studies	26% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	27% ± 11%	Explore
mucosal invariant T cell	10 studies	23% ± 5%	Explore
plasmacytoid dendritic cell	10 studies	28% ± 10%	Explore
ciliated cell	9 studies	35% ± 15%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	29% ± 9%	Explore
myofibroblast cell	8 studies	26% ± 5%	Explore
neuron	8 studies	31% ± 15%	Explore
abnormal cell	8 studies	29% ± 9%	Explore
T follicular helper cell	7 studies	24% ± 4%	Explore
plasmablast	6 studies	38% ± 22%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	31% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	30% ± 6%	Explore
capillary endothelial cell	6 studies	19% ± 3%	Explore
dendritic cell	6 studies	32% ± 19%	Explore
precursor B cell	6 studies	29% ± 10%	Explore
hematopoietic precursor cell	5 studies	35% ± 12%	Explore
leukocyte	5 studies	23% ± 6%	Explore
progenitor cell	5 studies	22% ± 5%	Explore
astrocyte	5 studies	23% ± 7%	Explore
endothelial cell of vascular tree	5 studies	18% ± 2%	Explore
innate lymphoid cell	5 studies	23% ± 6%	Explore
goblet cell	5 studies	24% ± 10%	Explore
oligodendrocyte	5 studies	19% ± 3%	Explore
secretory cell	4 studies	32% ± 18%	Explore
mononuclear phagocyte	4 studies	26% ± 12%	Explore
exhausted T cell	4 studies	37% ± 5%	Explore
endothelial cell of artery	4 studies	19% ± 2%	Explore
mesothelial cell	4 studies	31% ± 17%	Explore
pro-B cell	4 studies	28% ± 5%	Explore
myeloid cell	4 studies	28% ± 10%	Explore
immature B cell	4 studies	25% ± 5%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	35% ± 5%	Explore
endothelial cell of lymphatic vessel	4 studies	25% ± 9%	Explore
GABAergic neuron	4 studies	29% ± 11%	Explore
glutamatergic neuron	4 studies	35% ± 15%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	33% ± 6%	Explore
hematopoietic stem cell	4 studies	21% ± 4%	Explore
enteroendocrine cell	4 studies	31% ± 15%	Explore
T-helper 17 cell	4 studies	27% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	24% ± 4%	Explore
pancreatic A cell	3 studies	51% ± 18%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	23% ± 5%	Explore
neural crest cell	3 studies	29% ± 4%	Explore
vein endothelial cell	3 studies	18% ± 1%	Explore
extravillous trophoblast	3 studies	18% ± 1%	Explore
brush cell	3 studies	33% ± 13%	Explore
club cell	3 studies	27% ± 3%	Explore
type I pneumocyte	3 studies	27% ± 9%	Explore
amacrine cell	3 studies	38% ± 11%	Explore
retina horizontal cell	3 studies	34% ± 16%	Explore
intraepithelial lymphocyte	3 studies	30% ± 12%	Explore
Mueller cell	3 studies	21% ± 3%	Explore
germinal center B cell	3 studies	32% ± 5%	Explore
intermediate monocyte	3 studies	35% ± 17%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	42% ± 23%	Explore
intestinal crypt stem cell	3 studies	26% ± 5%	Explore
group 3 innate lymphoid cell	3 studies	33% ± 15%	Explore
T-helper 1 cell	3 studies	30% ± 5%	Explore
double negative thymocyte	3 studies	39% ± 17%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	17% ± 0%	Explore
oligodendrocyte precursor cell	3 studies	27% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	14 studies	28% ± 7%	Explore
lung	11 studies	30% ± 12%	Explore
intestine	7 studies	23% ± 11%	Explore
kidney	6 studies	21% ± 5%	Explore
lymph node	5 studies	26% ± 2%	Explore
brain	5 studies	29% ± 7%	Explore
eye	4 studies	24% ± 9%	Explore
liver	4 studies	30% ± 15%	Explore
pancreas	3 studies	44% ± 24%	Explore
bone marrow	3 studies	22% ± 4%	Explore
uterus	3 studies	31% ± 17%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1319.89	1445 / 1445	100%	53.23	183 / 183
ovary	100%	1796.36	180 / 180	100%	87.94	430 / 430
prostate	100%	1766.90	245 / 245	100%	73.75	502 / 502
skin	100%	1637.69	1809 / 1809	100%	87.01	472 / 472
stomach	100%	1031.24	359 / 359	100%	61.13	286 / 286
thymus	100%	1440.66	653 / 653	100%	66.02	605 / 605
uterus	100%	1718.19	170 / 170	100%	84.48	459 / 459
brain	100%	1478.52	2641 / 2642	100%	70.96	705 / 705
kidney	100%	1296.04	89 / 89	100%	45.71	900 / 901
lung	100%	1389.64	577 / 578	100%	71.59	1155 / 1155
intestine	100%	1388.24	966 / 966	100%	72.10	526 / 527
bladder	100%	1619.10	21 / 21	100%	85.55	503 / 504
breast	100%	1596.73	459 / 459	100%	67.46	1115 / 1118
liver	100%	912.49	226 / 226	99%	39.31	403 / 406
adrenal gland	100%	1722.80	258 / 258	99%	92.06	228 / 230
pancreas	99%	604.24	325 / 328	99%	66.37	177 / 178
adipose	100%	1419.72	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	69.97	80 / 80
lymph node	0%	0	0 / 0	100%	111.17	29 / 29
spleen	100%	1741.14	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	62.71	45 / 45
ureter	0%	0	0 / 0	100%	84.21	1 / 1
blood vessel	100%	1690.55	1334 / 1335	0%	0	0 / 0
heart	99%	793.19	855 / 861	0%	0	0 / 0
peripheral blood	99%	1536.59	918 / 929	0%	0	0 / 0
muscle	97%	549.70	782 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0042775	Biological process	mitochondrial ATP synthesis coupled electron transport
GO_0010977	Biological process	negative regulation of neuron projection development
GO_0046122	Biological process	purine deoxyribonucleoside metabolic process
GO_0008617	Biological process	guanosine metabolic process
GO_0046070	Biological process	dGTP metabolic process
GO_0106383	Biological process	dAMP salvage
GO_0005829	Cellular component	cytosol
GO_0005759	Cellular component	mitochondrial matrix
GO_0005737	Cellular component	cytoplasm
GO_0005739	Cellular component	mitochondrion
GO_0005634	Cellular component	nucleus
GO_0004136	Molecular function	deoxyadenosine kinase activity
GO_0004138	Molecular function	deoxyguanosine kinase activity
GO_0005524	Molecular function	ATP binding

IV. Literature review

[source]

Gene name	DGUOK
Protein name	DGUOK protein Deoxyguanosine kinase isoform 1 (Mitochondrial deoxyguanosine kinase) Deoxyguanosine kinase isoform 2 Deoxyguanosine kinase isoform 5 Deoxyguanosine kinase, mitochondrial (EC 2.7.1.113) (Deoxyadenosine kinase, mitochondrial) (EC 2.7.1.76)
Synonyms	DGK
Description	FUNCTION: Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine . In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs (By similarity). Widely used as target of antiviral and chemotherapeutic agents. .
Accessions	A0A0S2Z3T7 Q16854 ENST00000348222.3 [Q16854-2] ENST00000629438.2 [Q16854-6] ENST00000264093.9 [Q16854-1] E5KSL5 A0A0S2Z3N1 ENST00000418996.5 [Q16854-6] Q9BVK7

DGUOK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review