CST3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	51 studies	81% ± 23%	Explore
endothelial cell	47 studies	53% ± 24%	Explore
fibroblast	47 studies	68% ± 26%	Explore
pericyte	39 studies	62% ± 26%	Explore
conventional dendritic cell	34 studies	93% ± 13%	Explore
plasmacytoid dendritic cell	31 studies	86% ± 15%	Explore
smooth muscle cell	30 studies	59% ± 26%	Explore
dendritic cell	29 studies	81% ± 19%	Explore
monocyte	29 studies	81% ± 22%	Explore
classical monocyte	29 studies	91% ± 13%	Explore
non-classical monocyte	28 studies	91% ± 18%	Explore
mast cell	25 studies	58% ± 22%	Explore
endothelial cell of lymphatic vessel	25 studies	72% ± 21%	Explore
epithelial cell	24 studies	73% ± 24%	Explore
astrocyte	23 studies	62% ± 20%	Explore
basal cell	21 studies	54% ± 21%	Explore
connective tissue cell	21 studies	66% ± 26%	Explore
ciliated cell	17 studies	68% ± 23%	Explore
myeloid cell	17 studies	68% ± 30%	Explore
natural killer cell	16 studies	25% ± 9%	Explore
microglial cell	16 studies	51% ± 31%	Explore
oligodendrocyte precursor cell	15 studies	44% ± 18%	Explore
capillary endothelial cell	15 studies	46% ± 14%	Explore
myofibroblast cell	15 studies	68% ± 22%	Explore
endothelial cell of vascular tree	14 studies	61% ± 23%	Explore
endothelial cell of artery	13 studies	57% ± 14%	Explore
mesothelial cell	13 studies	64% ± 22%	Explore
vein endothelial cell	13 studies	65% ± 15%	Explore
secretory cell	12 studies	78% ± 18%	Explore
goblet cell	11 studies	69% ± 22%	Explore
T cell	10 studies	45% ± 25%	Explore
plasma cell	10 studies	39% ± 20%	Explore
club cell	10 studies	78% ± 26%	Explore
B cell	9 studies	22% ± 6%	Explore
type I pneumocyte	9 studies	72% ± 22%	Explore
type II pneumocyte	9 studies	72% ± 24%	Explore
neutrophil	9 studies	71% ± 28%	Explore
progenitor cell	9 studies	72% ± 20%	Explore
alveolar macrophage	8 studies	70% ± 35%	Explore
platelet	8 studies	67% ± 15%	Explore
mononuclear phagocyte	8 studies	80% ± 24%	Explore
enterocyte	8 studies	75% ± 28%	Explore
enteroendocrine cell	8 studies	70% ± 29%	Explore
leukocyte	8 studies	57% ± 20%	Explore
abnormal cell	7 studies	67% ± 15%	Explore
neuron	7 studies	53% ± 16%	Explore
erythrocyte	7 studies	36% ± 13%	Explore
ionocyte	6 studies	58% ± 15%	Explore
respiratory goblet cell	6 studies	79% ± 21%	Explore
epithelial cell of proximal tubule	6 studies	65% ± 15%	Explore
kidney loop of Henle epithelial cell	6 studies	65% ± 19%	Explore
renal alpha-intercalated cell	6 studies	71% ± 10%	Explore
gamma-delta T cell	6 studies	21% ± 4%	Explore
hematopoietic stem cell	6 studies	51% ± 16%	Explore
brush cell	6 studies	56% ± 13%	Explore
glial cell	6 studies	63% ± 17%	Explore
intermediate monocyte	6 studies	90% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	26% ± 6%	Explore
monocyte-derived dendritic cell	5 studies	91% ± 8%	Explore
GABAergic neuron	5 studies	32% ± 15%	Explore
oligodendrocyte	5 studies	25% ± 8%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	74% ± 12%	Explore
megakaryocyte	5 studies	77% ± 14%	Explore
erythroblast	5 studies	41% ± 23%	Explore
neuroendocrine cell	5 studies	88% ± 18%	Explore
Schwann cell	5 studies	61% ± 29%	Explore
retinal pigment epithelial cell	5 studies	64% ± 35%	Explore
mucus secreting cell	5 studies	75% ± 31%	Explore
adipocyte	5 studies	35% ± 24%	Explore
hepatocyte	5 studies	56% ± 22%	Explore
granulocyte	5 studies	54% ± 22%	Explore
CD16-positive, CD56-dim natural killer cell, human	5 studies	22% ± 4%	Explore
melanocyte	5 studies	77% ± 19%	Explore
deuterosomal cell	4 studies	65% ± 22%	Explore
duct epithelial cell	4 studies	92% ± 5%	Explore
squamous epithelial cell	4 studies	56% ± 26%	Explore
plasmablast	4 studies	35% ± 21%	Explore
pancreatic A cell	4 studies	89% ± 8%	Explore
type B pancreatic cell	4 studies	81% ± 13%	Explore
hematopoietic precursor cell	4 studies	50% ± 22%	Explore
innate lymphoid cell	4 studies	61% ± 26%	Explore
mature NK T cell	4 studies	28% ± 12%	Explore
intestinal crypt stem cell	4 studies	78% ± 16%	Explore
transit amplifying cell	4 studies	81% ± 14%	Explore
retinal ganglion cell	4 studies	72% ± 22%	Explore
retina horizontal cell	4 studies	33% ± 13%	Explore
adventitial cell	4 studies	90% ± 12%	Explore
chondrocyte	4 studies	41% ± 27%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	86% ± 8%	Explore
inflammatory macrophage	4 studies	74% ± 24%	Explore
luminal cell of prostate epithelium	4 studies	66% ± 25%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	55% ± 28%	Explore
Langerhans cell	3 studies	89% ± 12%	Explore
precursor cell	3 studies	61% ± 24%	Explore
CD4-positive, alpha-beta T cell	3 studies	23% ± 10%	Explore
pancreatic D cell	3 studies	87% ± 9%	Explore
hepatic stellate cell	3 studies	34% ± 16%	Explore
glutamatergic neuron	3 studies	33% ± 11%	Explore
podocyte	3 studies	63% ± 9%	Explore
renal intercalated cell	3 studies	52% ± 26%	Explore
neural crest cell	3 studies	44% ± 5%	Explore
IgA plasma cell	3 studies	17% ± 1%	Explore
paneth cell	3 studies	90% ± 9%	Explore
retinal bipolar neuron	3 studies	42% ± 18%	Explore
ON-bipolar cell	3 studies	46% ± 30%	Explore
retinal cone cell	3 studies	47% ± 16%	Explore
renal principal cell	3 studies	76% ± 9%	Explore
extravillous trophoblast	3 studies	47% ± 20%	Explore
placental villous trophoblast	3 studies	77% ± 21%	Explore
lymphocyte	3 studies	56% ± 17%	Explore
amacrine cell	3 studies	32% ± 8%	Explore
serous secreting cell	3 studies	80% ± 11%	Explore
tissue-resident macrophage	3 studies	78% ± 25%	Explore
Mueller cell	3 studies	43% ± 9%	Explore
rod bipolar cell	3 studies	76% ± 6%	Explore
endothelial cell of sinusoid	3 studies	29% ± 12%	Explore
myoepithelial cell	3 studies	62% ± 12%	Explore
muscle cell	3 studies	51% ± 17%	Explore
acinar cell	3 studies	61% ± 6%	Explore
pancreatic ductal cell	3 studies	59% ± 5%	Explore
group 3 innate lymphoid cell	3 studies	30% ± 17%	Explore
keratinocyte	3 studies	60% ± 7%	Explore
progenitor cell of mammary luminal epithelium	3 studies	37% ± 13%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	19 studies	56% ± 19%	Explore
peripheral blood	18 studies	38% ± 11%	Explore
brain	16 studies	32% ± 24%	Explore
intestine	13 studies	50% ± 26%	Explore
liver	10 studies	38% ± 19%	Explore
kidney	9 studies	48% ± 17%	Explore
eye	7 studies	35% ± 18%	Explore
heart	7 studies	26% ± 10%	Explore
uterus	6 studies	63% ± 25%	Explore
pancreas	5 studies	67% ± 25%	Explore
bone marrow	5 studies	33% ± 12%	Explore
prostate	5 studies	56% ± 21%	Explore
placenta	4 studies	56% ± 21%	Explore
adipose	4 studies	48% ± 21%	Explore
skin	4 studies	52% ± 24%	Explore
breast	4 studies	57% ± 8%	Explore
ovary	3 studies	46% ± 12%	Explore
adrenal gland	3 studies	31% ± 11%	Explore
esophagus	3 studies	50% ± 13%	Explore
stomach	3 studies	30% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	24496.64	652 / 653	100%	524.91	604 / 605
brain	100%	62858.92	2635 / 2642	100%	1114.19	704 / 705
prostate	100%	27809.25	244 / 245	100%	362.76	500 / 502
adrenal gland	100%	23458.97	258 / 258	99%	403.73	228 / 230
stomach	100%	26250.17	359 / 359	99%	477.18	283 / 286
ovary	99%	18964.72	178 / 180	100%	515.65	430 / 430
intestine	100%	25710.75	964 / 966	99%	442.32	522 / 527
esophagus	100%	29777.27	1442 / 1445	99%	299.12	181 / 183
skin	99%	16128.09	1787 / 1809	99%	372.47	466 / 472
bladder	100%	24393.76	21 / 21	96%	349.55	486 / 504
pancreas	97%	13233.94	318 / 328	99%	443.89	177 / 178
uterus	100%	22546.57	170 / 170	96%	265.65	442 / 459
kidney	96%	15939.94	85 / 89	99%	296.59	891 / 901
liver	97%	14657.56	219 / 226	97%	242.08	394 / 406
lung	99%	20991.62	570 / 578	95%	271.53	1100 / 1155
breast	100%	31712.21	459 / 459	92%	292.92	1024 / 1118
adipose	100%	34724.83	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	307.28	80 / 80
lymph node	0%	0	0 / 0	100%	279.16	29 / 29
tonsil	0%	0	0 / 0	100%	183.59	45 / 45
ureter	0%	0	0 / 0	100%	107.24	1 / 1
blood vessel	100%	35463.87	1331 / 1335	0%	0	0 / 0
spleen	100%	24159.91	240 / 241	0%	0	0 / 0
heart	99%	25052.61	853 / 861	0%	0	0 / 0
muscle	93%	14976.14	749 / 803	0%	0	0 / 0
peripheral blood	70%	10478.59	653 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0060311	Biological process	negative regulation of elastin catabolic process
GO_0010711	Biological process	negative regulation of collagen catabolic process
GO_2000117	Biological process	negative regulation of cysteine-type endopeptidase activity
GO_0060313	Biological process	negative regulation of blood vessel remodeling
GO_0097435	Biological process	supramolecular fiber organization
GO_0045861	Biological process	negative regulation of proteolysis
GO_0010466	Biological process	negative regulation of peptidase activity
GO_0034103	Biological process	regulation of tissue remodeling
GO_0010716	Biological process	negative regulation of extracellular matrix disassembly
GO_0006952	Biological process	defense response
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005794	Cellular component	Golgi apparatus
GO_0005788	Cellular component	endoplasmic reticulum lumen
GO_1904724	Cellular component	tertiary granule lumen
GO_1904813	Cellular component	ficolin-1-rich granule lumen
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005737	Cellular component	cytoplasm
GO_0031982	Cellular component	vesicle
GO_0004869	Molecular function	cysteine-type endopeptidase inhibitor activity
GO_0004866	Molecular function	endopeptidase inhibitor activity
GO_0001540	Molecular function	amyloid-beta binding
GO_0042802	Molecular function	identical protein binding
GO_0030414	Molecular function	peptidase inhibitor activity
GO_0002020	Molecular function	protease binding
GO_0005515	Molecular function	protein binding

Gene name	CST3
Protein name	Cystatin-C (Cystatin-3) (Gamma-trace) (Neuroendocrine basic polypeptide) (Post-gamma-globulin)
Synonyms
Description	FUNCTION: As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity.
Accessions	ENST00000398411.5 ENST00000376925.8 P01034 ENST00000398409.1

CST3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review