CMTM6 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	37 studies	41% ± 12%	Explore
B cell	36 studies	33% ± 11%	Explore
natural killer cell	29 studies	27% ± 7%	Explore
classical monocyte	27 studies	45% ± 13%	Explore
conventional dendritic cell	27 studies	51% ± 12%	Explore
monocyte	26 studies	42% ± 17%	Explore
non-classical monocyte	25 studies	60% ± 15%	Explore
CD4-positive, alpha-beta T cell	25 studies	26% ± 13%	Explore
dendritic cell	24 studies	49% ± 20%	Explore
endothelial cell	20 studies	25% ± 12%	Explore
memory B cell	20 studies	37% ± 10%	Explore
fibroblast	19 studies	27% ± 11%	Explore
CD8-positive, alpha-beta T cell	19 studies	24% ± 8%	Explore
regulatory T cell	19 studies	35% ± 15%	Explore
T cell	18 studies	22% ± 5%	Explore
plasmacytoid dendritic cell	18 studies	32% ± 10%	Explore
naive B cell	18 studies	30% ± 9%	Explore
mast cell	16 studies	34% ± 11%	Explore
ciliated cell	16 studies	44% ± 16%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	27% ± 7%	Explore
myeloid cell	14 studies	43% ± 16%	Explore
gamma-delta T cell	13 studies	27% ± 9%	Explore
basal cell	12 studies	31% ± 18%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	31% ± 9%	Explore
pericyte	12 studies	24% ± 9%	Explore
smooth muscle cell	12 studies	22% ± 5%	Explore
neutrophil	11 studies	39% ± 9%	Explore
mature NK T cell	11 studies	25% ± 5%	Explore
platelet	10 studies	30% ± 11%	Explore
mucosal invariant T cell	10 studies	24% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	25% ± 8%	Explore
secretory cell	9 studies	35% ± 20%	Explore
leukocyte	9 studies	36% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	9 studies	19% ± 3%	Explore
connective tissue cell	9 studies	28% ± 11%	Explore
alveolar macrophage	8 studies	29% ± 5%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	36% ± 18%	Explore
epithelial cell	8 studies	42% ± 24%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	21% ± 4%	Explore
endothelial cell of artery	8 studies	22% ± 3%	Explore
microglial cell	8 studies	31% ± 11%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	24% ± 9%	Explore
mononuclear phagocyte	7 studies	50% ± 20%	Explore
myofibroblast cell	7 studies	31% ± 7%	Explore
innate lymphoid cell	7 studies	36% ± 11%	Explore
T follicular helper cell	7 studies	23% ± 4%	Explore
hematopoietic precursor cell	6 studies	32% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	23% ± 4%	Explore
megakaryocyte	6 studies	66% ± 20%	Explore
goblet cell	6 studies	27% ± 11%	Explore
hematopoietic stem cell	6 studies	23% ± 9%	Explore
endothelial cell of vascular tree	6 studies	18% ± 2%	Explore
endothelial cell of lymphatic vessel	5 studies	20% ± 4%	Explore
plasmablast	5 studies	41% ± 17%	Explore
precursor B cell	5 studies	36% ± 8%	Explore
pro-B cell	5 studies	28% ± 3%	Explore
capillary endothelial cell	5 studies	19% ± 3%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	38% ± 19%	Explore
intermediate monocyte	5 studies	57% ± 24%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	39% ± 23%	Explore
abnormal cell	5 studies	20% ± 3%	Explore
club cell	4 studies	30% ± 12%	Explore
squamous epithelial cell	4 studies	33% ± 19%	Explore
pancreatic A cell	4 studies	44% ± 16%	Explore
exhausted T cell	4 studies	32% ± 9%	Explore
lymphocyte	4 studies	26% ± 13%	Explore
immature B cell	4 studies	23% ± 5%	Explore
Mueller cell	4 studies	37% ± 7%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	36% ± 10%	Explore
granulocyte	4 studies	31% ± 9%	Explore
luminal cell of prostate epithelium	4 studies	24% ± 6%	Explore
T-helper 17 cell	4 studies	37% ± 22%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	20% ± 3%	Explore
plasma cell	3 studies	33% ± 14%	Explore
respiratory goblet cell	3 studies	27% ± 13%	Explore
type B pancreatic cell	3 studies	40% ± 17%	Explore
monocyte-derived dendritic cell	3 studies	60% ± 4%	Explore
glomerular endothelial cell	3 studies	22% ± 1%	Explore
progenitor cell	3 studies	20% ± 3%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	23% ± 2%	Explore
placental villous trophoblast	3 studies	48% ± 13%	Explore
brush cell	3 studies	37% ± 17%	Explore
retina horizontal cell	3 studies	19% ± 3%	Explore
serous secreting cell	3 studies	17% ± 0%	Explore
tissue-resident macrophage	3 studies	42% ± 15%	Explore
germinal center B cell	3 studies	27% ± 4%	Explore
CD4-positive helper T cell	3 studies	26% ± 8%	Explore
type I pneumocyte	3 studies	23% ± 7%	Explore
GABAergic neuron	3 studies	23% ± 4%	Explore
glutamatergic neuron	3 studies	25% ± 7%	Explore
pancreatic ductal cell	3 studies	57% ± 14%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	53% ± 17%	Explore
enteroendocrine cell	3 studies	32% ± 17%	Explore
group 3 innate lymphoid cell	3 studies	49% ± 9%	Explore
T-helper 1 cell	3 studies	43% ± 23%	Explore
double negative thymocyte	3 studies	32% ± 9%	Explore
hepatocyte	3 studies	53% ± 21%	Explore
erythrocyte	3 studies	18% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	17 studies	30% ± 13%	Explore
peripheral blood	17 studies	30% ± 9%	Explore
intestine	8 studies	24% ± 11%	Explore
kidney	6 studies	22% ± 5%	Explore
bone marrow	5 studies	24% ± 7%	Explore
brain	5 studies	24% ± 7%	Explore
liver	5 studies	24% ± 4%	Explore
pancreas	4 studies	38% ± 18%	Explore
placenta	4 studies	30% ± 7%	Explore
uterus	4 studies	37% ± 21%	Explore
lymph node	4 studies	26% ± 3%	Explore
breast	4 studies	21% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3059.91	1444 / 1445	100%	78.47	183 / 183
lung	100%	4585.77	578 / 578	100%	96.88	1154 / 1155
bladder	100%	3839.86	21 / 21	100%	120.29	502 / 504
ovary	99%	1956.35	179 / 180	100%	171.72	430 / 430
breast	100%	3243.66	459 / 459	99%	119.49	1111 / 1118
stomach	100%	2542.07	359 / 359	99%	85.95	284 / 286
prostate	100%	3056.81	245 / 245	99%	111.24	498 / 502
intestine	100%	3184.76	966 / 966	99%	100.76	522 / 527
thymus	100%	3650.34	653 / 653	99%	124.52	598 / 605
uterus	100%	2695.91	170 / 170	98%	90.39	450 / 459
kidney	100%	2324.91	89 / 89	97%	61.23	877 / 901
pancreas	96%	1676.20	316 / 328	98%	110.19	175 / 178
skin	100%	5991.27	1809 / 1809	94%	70.38	444 / 472
liver	100%	5788.14	226 / 226	94%	53.23	380 / 406
adrenal gland	100%	2947.28	258 / 258	76%	24.65	175 / 230
brain	80%	880.25	2120 / 2642	92%	42.36	647 / 705
adipose	100%	3063.42	1204 / 1204	0%	0	0 / 0
spleen	100%	4780.88	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	68.94	1 / 1
blood vessel	100%	2845.00	1333 / 1335	0%	0	0 / 0
peripheral blood	99%	9456.49	923 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	80.31	44 / 45
lymph node	0%	0	0 / 0	97%	84.99	28 / 29
heart	91%	1279.41	782 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	61%	20.89	49 / 80
muscle	11%	92.98	90 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0015031	Biological process	protein transport
GO_0032456	Biological process	endocytic recycling
GO_0031647	Biological process	regulation of protein stability
GO_0031901	Cellular component	early endosome membrane
GO_0035577	Cellular component	azurophil granule membrane
GO_0055038	Cellular component	recycling endosome membrane
GO_0035579	Cellular component	specific granule membrane
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CMTM6
Protein name	CKLF-like MARVEL transmembrane domain-containing protein 6 (Chemokine-like factor superfamily member 6)
Synonyms	CKLFSF6
Description	FUNCTION: Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy. .
Accessions	Q9NX76 ENST00000205636.4

CMTM6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review