CLK1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	42 studies	30% ± 11%	Explore
fibroblast	40 studies	27% ± 10%	Explore
natural killer cell	35 studies	34% ± 12%	Explore
B cell	32 studies	32% ± 9%	Explore
macrophage	32 studies	31% ± 11%	Explore
CD8-positive, alpha-beta T cell	30 studies	32% ± 9%	Explore
T cell	29 studies	31% ± 12%	Explore
CD4-positive, alpha-beta T cell	28 studies	31% ± 9%	Explore
smooth muscle cell	27 studies	27% ± 9%	Explore
pericyte	23 studies	29% ± 8%	Explore
mast cell	21 studies	30% ± 9%	Explore
regulatory T cell	21 studies	34% ± 10%	Explore
conventional dendritic cell	20 studies	31% ± 15%	Explore
mature NK T cell	20 studies	30% ± 9%	Explore
classical monocyte	19 studies	26% ± 9%	Explore
naive B cell	17 studies	29% ± 9%	Explore
monocyte	16 studies	29% ± 10%	Explore
memory B cell	16 studies	29% ± 9%	Explore
dendritic cell	15 studies	28% ± 15%	Explore
non-classical monocyte	15 studies	28% ± 9%	Explore
astrocyte	15 studies	28% ± 11%	Explore
oligodendrocyte	15 studies	30% ± 11%	Explore
gamma-delta T cell	15 studies	33% ± 13%	Explore
plasmacytoid dendritic cell	15 studies	29% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	27% ± 9%	Explore
myofibroblast cell	14 studies	28% ± 9%	Explore
connective tissue cell	14 studies	29% ± 6%	Explore
epithelial cell	14 studies	33% ± 19%	Explore
capillary endothelial cell	13 studies	23% ± 6%	Explore
microglial cell	13 studies	29% ± 10%	Explore
basal cell	13 studies	28% ± 15%	Explore
endothelial cell of lymphatic vessel	12 studies	25% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	35% ± 9%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	36% ± 12%	Explore
mucosal invariant T cell	12 studies	28% ± 8%	Explore
endothelial cell of artery	11 studies	22% ± 5%	Explore
oligodendrocyte precursor cell	11 studies	29% ± 11%	Explore
endothelial cell of vascular tree	11 studies	29% ± 8%	Explore
plasma cell	10 studies	30% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	35% ± 10%	Explore
leukocyte	10 studies	36% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	30% ± 9%	Explore
vein endothelial cell	10 studies	24% ± 9%	Explore
type I pneumocyte	9 studies	22% ± 5%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	35% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	32% ± 11%	Explore
mesothelial cell	9 studies	29% ± 11%	Explore
ciliated cell	9 studies	31% ± 17%	Explore
progenitor cell	8 studies	24% ± 7%	Explore
myeloid cell	8 studies	29% ± 12%	Explore
neuron	7 studies	28% ± 13%	Explore
innate lymphoid cell	7 studies	33% ± 9%	Explore
T follicular helper cell	7 studies	35% ± 11%	Explore
mononuclear phagocyte	6 studies	29% ± 10%	Explore
glutamatergic neuron	6 studies	40% ± 21%	Explore
interneuron	6 studies	30% ± 18%	Explore
abnormal cell	6 studies	29% ± 7%	Explore
precursor B cell	6 studies	40% ± 15%	Explore
type II pneumocyte	6 studies	20% ± 5%	Explore
adipocyte	6 studies	22% ± 6%	Explore
goblet cell	6 studies	29% ± 14%	Explore
pro-B cell	5 studies	37% ± 6%	Explore
immature B cell	5 studies	39% ± 10%	Explore
lymphocyte	5 studies	38% ± 18%	Explore
GABAergic neuron	5 studies	40% ± 15%	Explore
squamous epithelial cell	4 studies	33% ± 19%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	33% ± 9%	Explore
plasmablast	4 studies	41% ± 21%	Explore
glomerular endothelial cell	4 studies	36% ± 14%	Explore
glial cell	4 studies	26% ± 10%	Explore
retina horizontal cell	4 studies	24% ± 3%	Explore
retinal cone cell	4 studies	27% ± 5%	Explore
retinal rod cell	4 studies	21% ± 2%	Explore
cardiac muscle cell	4 studies	16% ± 1%	Explore
Mueller cell	4 studies	40% ± 9%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	36% ± 12%	Explore
granulocyte	4 studies	28% ± 6%	Explore
group 3 innate lymphoid cell	4 studies	49% ± 10%	Explore
neutrophil	4 studies	20% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	24% ± 9%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	46% ± 10%	Explore
exhausted T cell	3 studies	37% ± 8%	Explore
hematopoietic precursor cell	3 studies	29% ± 15%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	19% ± 4%	Explore
renal alpha-intercalated cell	3 studies	34% ± 12%	Explore
kidney loop of Henle epithelial cell	3 studies	23% ± 5%	Explore
enterocyte	3 studies	20% ± 4%	Explore
amacrine cell	3 studies	25% ± 1%	Explore
retinal pigment epithelial cell	3 studies	49% ± 13%	Explore
tissue-resident macrophage	3 studies	35% ± 10%	Explore
rod bipolar cell	3 studies	31% ± 4%	Explore
respiratory goblet cell	3 studies	26% ± 10%	Explore
secretory cell	3 studies	24% ± 3%	Explore
chondrocyte	3 studies	32% ± 14%	Explore
endothelial cell of sinusoid	3 studies	21% ± 2%	Explore
germinal center B cell	3 studies	22% ± 5%	Explore
CD4-positive helper T cell	3 studies	34% ± 10%	Explore
enteroendocrine cell	3 studies	33% ± 12%	Explore
adventitial cell	3 studies	28% ± 9%	Explore
club cell	3 studies	24% ± 5%	Explore
alveolar macrophage	3 studies	21% ± 3%	Explore
melanocyte	3 studies	36% ± 10%	Explore
keratinocyte	3 studies	28% ± 5%	Explore
T-helper 17 cell	3 studies	30% ± 6%	Explore
hepatocyte	3 studies	40% ± 7%	Explore
double negative thymocyte	3 studies	40% ± 21%	Explore
mural cell	3 studies	32% ± 12%	Explore
luminal cell of prostate epithelium	3 studies	22% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	28% ± 14%	Explore
lung	14 studies	28% ± 10%	Explore
peripheral blood	12 studies	30% ± 12%	Explore
intestine	9 studies	25% ± 8%	Explore
eye	9 studies	27% ± 11%	Explore
kidney	8 studies	27% ± 7%	Explore
uterus	5 studies	30% ± 8%	Explore
liver	5 studies	34% ± 10%	Explore
heart	4 studies	16% ± 1%	Explore
adipose	4 studies	23% ± 3%	Explore
prostate	4 studies	21% ± 6%	Explore
skin	4 studies	24% ± 7%	Explore
lymph node	4 studies	29% ± 10%	Explore
breast	4 studies	24% ± 6%	Explore
bone marrow	3 studies	26% ± 7%	Explore
adrenal gland	3 studies	26% ± 7%	Explore
esophagus	3 studies	34% ± 20%	Explore
pancreas	3 studies	30% ± 10%	Explore
thymus	3 studies	38% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	14120.10	245 / 245	100%	64.43	502 / 502
breast	100%	13818.42	459 / 459	100%	53.69	1116 / 1118
thymus	100%	15747.07	653 / 653	100%	81.95	603 / 605
adrenal gland	100%	9634.81	258 / 258	100%	46.41	229 / 230
esophagus	100%	11269.63	1445 / 1445	99%	45.95	182 / 183
pancreas	100%	7443.87	328 / 328	99%	59.23	177 / 178
uterus	100%	15063.97	170 / 170	99%	51.77	456 / 459
bladder	100%	10886.10	21 / 21	99%	41.59	500 / 504
lung	100%	14027.13	577 / 578	99%	41.48	1146 / 1155
brain	98%	7466.67	2602 / 2642	100%	55.65	704 / 705
stomach	100%	8070.47	359 / 359	98%	32.55	279 / 286
intestine	100%	11363.63	966 / 966	98%	34.32	514 / 527
kidney	100%	9227.12	89 / 89	97%	53.20	876 / 901
ovary	100%	17261.77	180 / 180	97%	29.89	417 / 430
liver	99%	5946.31	223 / 226	94%	26.81	383 / 406
skin	99%	8200.28	1784 / 1809	90%	35.87	427 / 472
spleen	100%	16410.64	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	38.51	45 / 45
ureter	0%	0	0 / 0	100%	18.13	1 / 1
blood vessel	100%	13496.91	1334 / 1335	0%	0	0 / 0
adipose	100%	13661.23	1203 / 1204	0%	0	0 / 0
heart	98%	6567.36	844 / 861	0%	0	0 / 0
muscle	97%	6461.84	777 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	44.48	28 / 29
peripheral blood	85%	4913.67	793 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	74%	28.90	59 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0043484	Biological process	regulation of RNA splicing
GO_0018108	Biological process	peptidyl-tyrosine phosphorylation
GO_0005634	Cellular component	nucleus
GO_0004713	Molecular function	protein tyrosine kinase activity
GO_0004715	Molecular function	non-membrane spanning protein tyrosine kinase activity
GO_0004712	Molecular function	protein serine/threonine/tyrosine kinase activity
GO_0004674	Molecular function	protein serine/threonine kinase activity
GO_0005515	Molecular function	protein binding
GO_0106310	Molecular function	protein serine kinase activity
GO_0005524	Molecular function	ATP binding

IV. Literature review

[source]

Gene name	CLK1
Protein name	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) dual-specificity kinase (EC 2.7.12.1)
Synonyms	CLK
Description	FUNCTION: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1 . Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells . .
Accessions	ENST00000432425.5 [P49759-2] ENST00000321356.9 [P49759-1] F8WBF5 ENST00000434813.3 [P49759-3] B8ZZR0 P49759 ENST00000409403.6 ENST00000409769.6

CLK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review