CHD1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	37 studies	27% ± 10%	Explore
B cell	31 studies	28% ± 8%	Explore
natural killer cell	31 studies	26% ± 9%	Explore
macrophage	27 studies	30% ± 13%	Explore
fibroblast	25 studies	28% ± 10%	Explore
CD4-positive, alpha-beta T cell	25 studies	24% ± 8%	Explore
T cell	24 studies	25% ± 10%	Explore
classical monocyte	22 studies	31% ± 9%	Explore
CD8-positive, alpha-beta T cell	22 studies	23% ± 8%	Explore
non-classical monocyte	21 studies	32% ± 11%	Explore
conventional dendritic cell	20 studies	26% ± 11%	Explore
monocyte	19 studies	33% ± 13%	Explore
pericyte	18 studies	30% ± 13%	Explore
smooth muscle cell	18 studies	27% ± 11%	Explore
memory B cell	18 studies	27% ± 6%	Explore
regulatory T cell	18 studies	26% ± 7%	Explore
naive B cell	15 studies	25% ± 7%	Explore
mast cell	14 studies	23% ± 6%	Explore
microglial cell	14 studies	36% ± 13%	Explore
dendritic cell	13 studies	35% ± 14%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	25% ± 7%	Explore
mucosal invariant T cell	13 studies	26% ± 7%	Explore
gamma-delta T cell	13 studies	28% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	28% ± 8%	Explore
astrocyte	12 studies	27% ± 12%	Explore
mature NK T cell	11 studies	25% ± 5%	Explore
oligodendrocyte precursor cell	11 studies	25% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	28% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	26% ± 12%	Explore
connective tissue cell	10 studies	21% ± 6%	Explore
endothelial cell of vascular tree	10 studies	27% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	29% ± 13%	Explore
myeloid cell	9 studies	33% ± 9%	Explore
basal cell	9 studies	28% ± 13%	Explore
oligodendrocyte	9 studies	25% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	25% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	22% ± 6%	Explore
epithelial cell	8 studies	37% ± 21%	Explore
vein endothelial cell	8 studies	28% ± 16%	Explore
ciliated cell	8 studies	26% ± 12%	Explore
endothelial cell of lymphatic vessel	7 studies	25% ± 8%	Explore
leukocyte	7 studies	30% ± 10%	Explore
plasmacytoid dendritic cell	7 studies	21% ± 11%	Explore
innate lymphoid cell	7 studies	26% ± 8%	Explore
GABAergic neuron	7 studies	35% ± 18%	Explore
neutrophil	6 studies	28% ± 5%	Explore
mononuclear phagocyte	6 studies	27% ± 7%	Explore
interneuron	6 studies	36% ± 20%	Explore
capillary endothelial cell	6 studies	21% ± 8%	Explore
retinal rod cell	6 studies	19% ± 3%	Explore
adipocyte	6 studies	26% ± 8%	Explore
endothelial cell of artery	6 studies	22% ± 7%	Explore
type I pneumocyte	5 studies	21% ± 5%	Explore
secretory cell	5 studies	21% ± 5%	Explore
abnormal cell	5 studies	25% ± 11%	Explore
precursor B cell	5 studies	29% ± 11%	Explore
pro-B cell	5 studies	34% ± 9%	Explore
lymphocyte	5 studies	35% ± 13%	Explore
T follicular helper cell	5 studies	27% ± 5%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	31% ± 14%	Explore
type II pneumocyte	5 studies	22% ± 6%	Explore
glutamatergic neuron	5 studies	48% ± 20%	Explore
club cell	5 studies	24% ± 7%	Explore
hematopoietic precursor cell	4 studies	30% ± 12%	Explore
neuron	4 studies	31% ± 9%	Explore
myofibroblast cell	4 studies	31% ± 9%	Explore
immature B cell	4 studies	25% ± 5%	Explore
retinal pigment epithelial cell	4 studies	31% ± 13%	Explore
Mueller cell	4 studies	29% ± 15%	Explore
CD4-positive helper T cell	4 studies	30% ± 12%	Explore
glial cell	3 studies	24% ± 5%	Explore
granule cell	3 studies	23% ± 4%	Explore
progenitor cell	3 studies	23% ± 5%	Explore
plasma cell	3 studies	26% ± 5%	Explore
retina horizontal cell	3 studies	20% ± 4%	Explore
retinal cone cell	3 studies	22% ± 1%	Explore
cardiac muscle cell	3 studies	16% ± 1%	Explore
mesothelial cell	3 studies	21% ± 1%	Explore
glycinergic amacrine cell	3 studies	20% ± 1%	Explore
melanocyte	3 studies	33% ± 8%	Explore
respiratory goblet cell	3 studies	27% ± 2%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	21% ± 1%	Explore
hepatocyte	3 studies	36% ± 24%	Explore
muscle cell	3 studies	31% ± 10%	Explore
neural progenitor cell	3 studies	27% ± 5%	Explore
adventitial cell	3 studies	25% ± 6%	Explore
alveolar macrophage	3 studies	33% ± 11%	Explore
group 3 innate lymphoid cell	3 studies	43% ± 14%	Explore
goblet cell	3 studies	36% ± 25%	Explore
myoepithelial cell	3 studies	28% ± 5%	Explore
mural cell	3 studies	33% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	22% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	12 studies	28% ± 9%	Explore
brain	12 studies	32% ± 16%	Explore
lung	10 studies	25% ± 8%	Explore
eye	8 studies	26% ± 11%	Explore
intestine	5 studies	20% ± 4%	Explore
kidney	5 studies	17% ± 2%	Explore
liver	5 studies	29% ± 11%	Explore
bone marrow	4 studies	22% ± 4%	Explore
uterus	4 studies	28% ± 7%	Explore
adipose	4 studies	23% ± 5%	Explore
heart	3 studies	19% ± 3%	Explore
breast	3 studies	26% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2571.20	1445 / 1445	100%	19.46	183 / 183
lung	100%	4456.63	578 / 578	100%	13.61	1151 / 1155
breast	100%	3877.14	459 / 459	99%	25.28	1111 / 1118
thymus	100%	3087.94	653 / 653	99%	15.99	596 / 605
bladder	100%	2815.14	21 / 21	98%	11.93	496 / 504
uterus	100%	3690.20	170 / 170	98%	13.32	451 / 459
intestine	100%	3461.79	966 / 966	98%	15.75	516 / 527
pancreas	99%	1730.71	326 / 328	98%	13.28	175 / 178
stomach	100%	2427.46	359 / 359	98%	15.68	279 / 286
kidney	100%	2129.53	89 / 89	96%	13.74	862 / 901
adrenal gland	100%	2816.41	258 / 258	96%	8.12	220 / 230
prostate	100%	3017.79	245 / 245	95%	10.63	476 / 502
skin	100%	3152.55	1808 / 1809	95%	18.01	447 / 472
brain	95%	1562.98	2517 / 2642	99%	11.07	699 / 705
ovary	100%	6112.21	180 / 180	92%	6.77	395 / 430
liver	100%	1829.40	226 / 226	87%	6.53	355 / 406
adipose	100%	4492.11	1204 / 1204	0%	0	0 / 0
blood vessel	100%	3218.62	1335 / 1335	0%	0	0 / 0
spleen	100%	4365.84	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	14.01	45 / 45
muscle	100%	2205.68	800 / 803	0%	0	0 / 0
heart	97%	1586.57	836 / 861	0%	0	0 / 0
peripheral blood	96%	3520.11	892 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	93%	13.16	27 / 29
eye	0%	0	0 / 0	61%	5.75	49 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006338	Biological process	chromatin remodeling
GO_0034728	Biological process	nucleosome organization
GO_0043923	Biological process	positive regulation by host of viral transcription
GO_0000228	Cellular component	nuclear chromosome
GO_0005654	Cellular component	nucleoplasm
GO_0000785	Cellular component	chromatin
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0035064	Molecular function	methylated histone binding
GO_0003677	Molecular function	DNA binding
GO_0140658	Molecular function	ATP-dependent chromatin remodeler activity
GO_0004386	Molecular function	helicase activity
GO_0005515	Molecular function	protein binding
GO_0016887	Molecular function	ATP hydrolysis activity
GO_0042393	Molecular function	histone binding
GO_0003682	Molecular function	chromatin binding
GO_0005524	Molecular function	ATP binding

IV. Literature review

[source]

Gene name	CHD1
Protein name	Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.12) (ATP-dependent helicase CHD1) Alternative protein CHD1 Chromodomain helicase DNA binding protein 1 CHD1 protein DNA helicase (EC 3.6.4.12)
Synonyms
Description	FUNCTION: ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 . Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). .
Accessions	A0A087WVF4 H0Y8Z0 ENST00000706141.1 ENST00000614616.5 [O14646-1] ENST00000512844.5 ENST00000505657.1 ENST00000511067.3 A0A994J7K7 H0Y8V4 O14646 L8E9V9 Q7Z4M7

CHD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review