CDC42SE2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	41 studies	35% ± 12%	Explore
B cell	37 studies	33% ± 14%	Explore
CD8-positive, alpha-beta T cell	37 studies	38% ± 13%	Explore
T cell	34 studies	39% ± 14%	Explore
CD4-positive, alpha-beta T cell	34 studies	38% ± 14%	Explore
regulatory T cell	25 studies	38% ± 9%	Explore
macrophage	21 studies	30% ± 18%	Explore
mature NK T cell	20 studies	36% ± 11%	Explore
endothelial cell	19 studies	27% ± 9%	Explore
naive B cell	18 studies	26% ± 7%	Explore
memory B cell	18 studies	30% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	41% ± 13%	Explore
gamma-delta T cell	17 studies	38% ± 10%	Explore
dendritic cell	16 studies	40% ± 23%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	35% ± 10%	Explore
plasmacytoid dendritic cell	15 studies	27% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	37% ± 12%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	41% ± 12%	Explore
conventional dendritic cell	14 studies	27% ± 10%	Explore
mucosal invariant T cell	14 studies	41% ± 11%	Explore
CD4-positive, alpha-beta memory T cell	13 studies	37% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	43% ± 12%	Explore
oligodendrocyte	13 studies	38% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	48% ± 16%	Explore
mast cell	12 studies	30% ± 13%	Explore
plasma cell	11 studies	32% ± 15%	Explore
astrocyte	11 studies	31% ± 14%	Explore
microglial cell	11 studies	39% ± 13%	Explore
myeloid cell	11 studies	31% ± 12%	Explore
monocyte	11 studies	33% ± 15%	Explore
glutamatergic neuron	10 studies	47% ± 24%	Explore
classical monocyte	9 studies	23% ± 10%	Explore
leukocyte	9 studies	48% ± 18%	Explore
oligodendrocyte precursor cell	9 studies	28% ± 11%	Explore
epithelial cell	9 studies	37% ± 15%	Explore
platelet	8 studies	22% ± 8%	Explore
T follicular helper cell	8 studies	41% ± 8%	Explore
GABAergic neuron	8 studies	44% ± 21%	Explore
ciliated cell	8 studies	31% ± 13%	Explore
innate lymphoid cell	8 studies	33% ± 12%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	34% ± 10%	Explore
non-classical monocyte	7 studies	30% ± 15%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	34% ± 7%	Explore
mononuclear phagocyte	6 studies	30% ± 8%	Explore
neuron	6 studies	38% ± 19%	Explore
lymphocyte	6 studies	51% ± 28%	Explore
club cell	6 studies	23% ± 6%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	46% ± 18%	Explore
endothelial cell of lymphatic vessel	6 studies	38% ± 9%	Explore
type I pneumocyte	6 studies	24% ± 5%	Explore
type II pneumocyte	6 studies	22% ± 5%	Explore
exhausted T cell	5 studies	42% ± 15%	Explore
hematopoietic precursor cell	5 studies	36% ± 22%	Explore
CD4-positive helper T cell	5 studies	41% ± 17%	Explore
goblet cell	5 studies	26% ± 12%	Explore
basal cell	5 studies	33% ± 13%	Explore
interneuron	5 studies	45% ± 21%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	41% ± 17%	Explore
precursor B cell	4 studies	25% ± 7%	Explore
abnormal cell	4 studies	27% ± 11%	Explore
hematopoietic stem cell	4 studies	26% ± 13%	Explore
fibroblast	4 studies	18% ± 2%	Explore
T-helper 17 cell	4 studies	39% ± 16%	Explore
double negative thymocyte	4 studies	38% ± 7%	Explore
pancreatic A cell	3 studies	36% ± 8%	Explore
type B pancreatic cell	3 studies	37% ± 15%	Explore
plasmablast	3 studies	39% ± 13%	Explore
GABAergic interneuron	3 studies	25% ± 2%	Explore
thymocyte	3 studies	23% ± 5%	Explore
endothelial cell of vascular tree	3 studies	29% ± 10%	Explore
ependymal cell	3 studies	35% ± 10%	Explore
granulocyte	3 studies	35% ± 17%	Explore
enteroendocrine cell	3 studies	26% ± 8%	Explore
respiratory goblet cell	3 studies	37% ± 7%	Explore
alveolar macrophage	3 studies	33% ± 8%	Explore
group 3 innate lymphoid cell	3 studies	33% ± 11%	Explore
T-helper 1 cell	3 studies	38% ± 14%	Explore
immature B cell	3 studies	22% ± 8%	Explore
adipocyte	3 studies	21% ± 4%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	38% ± 4%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	35% ± 9%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	31% ± 5%	Explore
renal alpha-intercalated cell	3 studies	26% ± 8%	Explore
mucus secreting cell	3 studies	22% ± 2%	Explore
erythrocyte	3 studies	21% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	17 studies	33% ± 12%	Explore
brain	14 studies	39% ± 21%	Explore
lung	13 studies	24% ± 7%	Explore
intestine	6 studies	22% ± 3%	Explore
liver	5 studies	31% ± 10%	Explore
bone marrow	4 studies	29% ± 8%	Explore
lymph node	4 studies	29% ± 10%	Explore
kidney	4 studies	22% ± 5%	Explore
adipose	4 studies	22% ± 2%	Explore
pancreas	3 studies	36% ± 11%	Explore
placenta	3 studies	21% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	3411.19	578 / 578	100%	44.61	1155 / 1155
brain	100%	3697.20	2640 / 2642	100%	48.96	705 / 705
thymus	100%	3833.24	653 / 653	100%	59.53	604 / 605
intestine	100%	4007.10	966 / 966	100%	53.25	526 / 527
prostate	100%	2604.43	245 / 245	100%	54.59	501 / 502
ovary	100%	2312.31	180 / 180	100%	25.66	429 / 430
kidney	100%	4078.46	89 / 89	100%	69.65	898 / 901
stomach	100%	1761.74	359 / 359	100%	44.58	285 / 286
breast	100%	2742.43	459 / 459	100%	38.51	1114 / 1118
uterus	100%	1954.11	170 / 170	99%	31.30	454 / 459
pancreas	100%	2232.37	328 / 328	99%	44.51	176 / 178
esophagus	100%	1658.28	1442 / 1445	99%	31.00	181 / 183
bladder	100%	2225.24	21 / 21	98%	38.15	496 / 504
liver	100%	1282.09	226 / 226	93%	22.30	378 / 406
skin	100%	2063.15	1805 / 1809	93%	26.98	439 / 472
adrenal gland	99%	1327.68	256 / 258	92%	19.38	212 / 230
adipose	100%	2555.21	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	88.48	29 / 29
spleen	100%	6186.95	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	38.54	45 / 45
ureter	0%	0	0 / 0	100%	8.49	1 / 1
blood vessel	100%	1988.04	1332 / 1335	0%	0	0 / 0
peripheral blood	99%	6967.25	916 / 929	0%	0	0 / 0
muscle	96%	1346.21	771 / 803	0%	0	0 / 0
heart	86%	820.13	741 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	63%	10.34	50 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0009966	Biological process	regulation of signal transduction
GO_0008360	Biological process	regulation of cell shape
GO_0035023	Biological process	regulation of Rho protein signal transduction
GO_0006909	Biological process	phagocytosis
GO_0042995	Cellular component	cell projection
GO_0005856	Cellular component	cytoskeleton
GO_0001891	Cellular component	phagocytic cup
GO_0005886	Cellular component	plasma membrane
GO_0005737	Cellular component	cytoplasm
GO_0035591	Molecular function	signaling adaptor activity
GO_0005515	Molecular function	protein binding
GO_0031267	Molecular function	small GTPase binding

IV. Literature review

[source]

Gene name	CDC42SE2
Protein name	CDC42 small effector protein 2 (Small effector of CDC42 protein 2) CDC42 small effector protein 2 CDC42 small effector 2
Synonyms	SPEC2
Description	FUNCTION: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages. . FUNCTION: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages. .
Accessions	D6REL0 ENST00000505065.2 ENST00000503291.5 ENST00000360515.7 H0Y9W5 Q9NRR3 ENST00000502582.1 ENST00000395246.5

CDC42SE2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review