C9orf78 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000398Biological processmRNA splicing, via spliceosome
GO_0007059Biological processchromosome segregation
GO_0060629Biological processregulation of homologous chromosome segregation
GO_0045292Biological processmRNA cis splicing, via spliceosome
GO_0000775Cellular componentchromosome, centromeric region
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005681Cellular componentspliceosomal complex
GO_0005634Cellular componentnucleus
GO_0030623Molecular functionU5 snRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameC9orf78
Protein nameHepatocellular carcinoma-associated antigen 59
Splicing factor C9orf78 (Hepatocellular carcinoma-associated antigen 59)
SynonymsHCA59
DescriptionFUNCTION: Plays a role in pre-mRNA splicing by promoting usage of the upstream 3'-splice site at alternative NAGNAG splice sites; these are sites featuring alternative acceptor motifs separated by only a few nucleotides . May also modulate exon inclusion events . Plays a role in spliceosomal remodeling by displacing WBP4 from SNRNP200 and may act to inhibit SNRNP200 helicase activity . Binds U5 snRNA . Required for proper chromosome segregation . Not required for splicing of shelterin components . .

AccessionsENST00000372447.7
Q6GVN4
Q9NZ63