BUD23 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	18 studies	21% ± 5%	Explore
CD8-positive, alpha-beta T cell	16 studies	22% ± 6%	Explore
ciliated cell	15 studies	41% ± 13%	Explore
B cell	15 studies	22% ± 7%	Explore
regulatory T cell	15 studies	19% ± 3%	Explore
CD4-positive, alpha-beta T cell	14 studies	23% ± 7%	Explore
plasma cell	12 studies	34% ± 11%	Explore
epithelial cell	11 studies	33% ± 21%	Explore
plasmacytoid dendritic cell	11 studies	30% ± 9%	Explore
naive B cell	10 studies	21% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	22% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	23% ± 6%	Explore
T cell	9 studies	20% ± 5%	Explore
endothelial cell	9 studies	29% ± 9%	Explore
basal cell	9 studies	29% ± 13%	Explore
gamma-delta T cell	9 studies	25% ± 13%	Explore
plasmablast	8 studies	42% ± 22%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	22% ± 4%	Explore
conventional dendritic cell	8 studies	30% ± 14%	Explore
memory B cell	8 studies	20% ± 3%	Explore
mucosal invariant T cell	8 studies	20% ± 3%	Explore
fibroblast	8 studies	23% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	7 studies	21% ± 3%	Explore
mature NK T cell	7 studies	18% ± 2%	Explore
abnormal cell	7 studies	24% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	19% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	25% ± 7%	Explore
T follicular helper cell	5 studies	18% ± 2%	Explore
endothelial cell of vascular tree	5 studies	20% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	23% ± 4%	Explore
dendritic cell	5 studies	39% ± 22%	Explore
goblet cell	5 studies	23% ± 5%	Explore
secretory cell	4 studies	25% ± 11%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	20% ± 4%	Explore
exhausted T cell	4 studies	22% ± 4%	Explore
kidney loop of Henle epithelial cell	4 studies	17% ± 1%	Explore
connective tissue cell	4 studies	19% ± 3%	Explore
smooth muscle cell	4 studies	21% ± 6%	Explore
precursor B cell	4 studies	23% ± 2%	Explore
immature B cell	4 studies	20% ± 3%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	22% ± 10%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	24% ± 4%	Explore
deuterosomal cell	3 studies	21% ± 1%	Explore
pancreatic A cell	3 studies	53% ± 14%	Explore
non-classical monocyte	3 studies	28% ± 9%	Explore
pericyte	3 studies	22% ± 2%	Explore
erythroblast	3 studies	27% ± 9%	Explore
capillary endothelial cell	3 studies	16% ± 1%	Explore
macrophage	3 studies	27% ± 6%	Explore
endothelial cell of lymphatic vessel	3 studies	24% ± 6%	Explore
enteroendocrine cell	3 studies	32% ± 12%	Explore
intestinal crypt stem cell	3 studies	24% ± 3%	Explore
mast cell	3 studies	18% ± 3%	Explore
double negative thymocyte	3 studies	30% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	13 studies	21% ± 7%	Explore
lung	11 studies	23% ± 9%	Explore
breast	4 studies	18% ± 2%	Explore
intestine	4 studies	21% ± 8%	Explore
pancreas	3 studies	42% ± 19%	Explore
brain	3 studies	27% ± 3%	Explore
liver	3 studies	25% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	2936.51	258 / 258	100%	41.48	230 / 230
lung	100%	2565.65	578 / 578	100%	40.63	1155 / 1155
ovary	100%	2741.54	180 / 180	100%	34.57	430 / 430
pancreas	100%	1729.81	328 / 328	100%	37.49	178 / 178
skin	100%	2836.91	1809 / 1809	100%	56.58	472 / 472
stomach	100%	2144.53	359 / 359	100%	36.08	286 / 286
thymus	100%	3087.48	653 / 653	100%	39.63	605 / 605
uterus	100%	2942.32	170 / 170	100%	42.38	459 / 459
kidney	100%	2498.55	89 / 89	100%	27.49	900 / 901
intestine	100%	2507.11	966 / 966	100%	43.65	526 / 527
bladder	100%	2719.86	21 / 21	100%	43.58	503 / 504
prostate	100%	2718.85	245 / 245	100%	36.62	501 / 502
breast	100%	2818.49	459 / 459	100%	40.04	1115 / 1118
brain	100%	1818.00	2632 / 2642	100%	35.01	705 / 705
liver	100%	1623.06	225 / 226	100%	24.39	406 / 406
esophagus	100%	2342.69	1445 / 1445	99%	29.93	182 / 183
adipose	100%	2516.30	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	37.71	80 / 80
lymph node	0%	0	0 / 0	100%	50.49	29 / 29
muscle	100%	4208.54	803 / 803	0%	0	0 / 0
spleen	100%	2741.46	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	30.78	45 / 45
ureter	0%	0	0 / 0	100%	31.40	1 / 1
blood vessel	100%	2509.36	1334 / 1335	0%	0	0 / 0
heart	99%	2800.63	852 / 861	0%	0	0 / 0
peripheral blood	86%	1562.51	797 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006325	Biological process	chromatin organization
GO_2000234	Biological process	positive regulation of rRNA processing
GO_0070476	Biological process	rRNA (guanine-N7)-methylation
GO_0005730	Cellular component	nucleolus
GO_0005654	Cellular component	nucleoplasm
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005634	Cellular component	nucleus
GO_0046982	Molecular function	protein heterodimerization activity
GO_0016435	Molecular function	rRNA (guanine) methyltransferase activity
GO_0005515	Molecular function	protein binding
GO_0008168	Molecular function	methyltransferase activity
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	BUD23
Protein name	Probable 18S rRNA (guanine-N(7))-methyltransferase (EC 2.1.1.-) (Bud site selection protein 23 homolog) (Metastasis-related methyltransferase 1) (Williams-Beuren syndrome chromosomal region 22 protein) (rRNA methyltransferase and ribosome maturation factor) Uncharacterized protein WBSCR22
Synonyms	HUSSY-03 PP3381 MERM1 WBSCR22
Description	FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA . Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity . Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity . Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity . Locus-specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors . Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements . Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2), although direct histone methyltransferase activity is not observed in vitro . .
Accessions	Q75ME3 ENST00000265758.7 [O43709-1] O43709

BUD23 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review