BAZ1A | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	34 studies	25% ± 6%	Explore
macrophage	34 studies	28% ± 10%	Explore
endothelial cell	33 studies	26% ± 8%	Explore
natural killer cell	32 studies	25% ± 5%	Explore
CD4-positive, alpha-beta T cell	31 studies	26% ± 7%	Explore
CD8-positive, alpha-beta T cell	29 studies	24% ± 6%	Explore
T cell	26 studies	27% ± 5%	Explore
classical monocyte	23 studies	33% ± 10%	Explore
conventional dendritic cell	22 studies	31% ± 14%	Explore
non-classical monocyte	22 studies	34% ± 10%	Explore
regulatory T cell	21 studies	28% ± 6%	Explore
dendritic cell	20 studies	33% ± 14%	Explore
monocyte	20 studies	33% ± 10%	Explore
memory B cell	18 studies	23% ± 5%	Explore
naive B cell	18 studies	25% ± 6%	Explore
basal cell	15 studies	31% ± 11%	Explore
fibroblast	15 studies	26% ± 8%	Explore
plasmacytoid dendritic cell	14 studies	24% ± 9%	Explore
myeloid cell	14 studies	31% ± 11%	Explore
ciliated cell	13 studies	29% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	28% ± 10%	Explore
mature NK T cell	13 studies	24% ± 5%	Explore
pericyte	13 studies	23% ± 8%	Explore
gamma-delta T cell	13 studies	28% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	29% ± 3%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	22% ± 5%	Explore
mast cell	11 studies	23% ± 8%	Explore
epithelial cell	11 studies	38% ± 19%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	26% ± 8%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	30% ± 8%	Explore
leukocyte	10 studies	28% ± 6%	Explore
mucosal invariant T cell	10 studies	23% ± 5%	Explore
capillary endothelial cell	10 studies	22% ± 8%	Explore
endothelial cell of vascular tree	10 studies	31% ± 9%	Explore
endothelial cell of lymphatic vessel	9 studies	25% ± 6%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	26% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	30% ± 8%	Explore
vein endothelial cell	9 studies	28% ± 10%	Explore
smooth muscle cell	9 studies	20% ± 5%	Explore
type I pneumocyte	8 studies	21% ± 4%	Explore
neutrophil	8 studies	23% ± 4%	Explore
secretory cell	8 studies	28% ± 13%	Explore
microglial cell	8 studies	25% ± 8%	Explore
mononuclear phagocyte	7 studies	34% ± 10%	Explore
T follicular helper cell	7 studies	27% ± 11%	Explore
type II pneumocyte	7 studies	27% ± 4%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	25% ± 6%	Explore
lymphocyte	6 studies	35% ± 8%	Explore
precursor B cell	6 studies	33% ± 11%	Explore
innate lymphoid cell	6 studies	26% ± 8%	Explore
club cell	6 studies	23% ± 5%	Explore
adipocyte	6 studies	21% ± 4%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	28% ± 11%	Explore
oligodendrocyte	6 studies	21% ± 7%	Explore
abnormal cell	6 studies	20% ± 4%	Explore
goblet cell	6 studies	30% ± 20%	Explore
respiratory goblet cell	5 studies	28% ± 11%	Explore
hematopoietic precursor cell	5 studies	35% ± 13%	Explore
connective tissue cell	5 studies	21% ± 4%	Explore
pro-B cell	5 studies	32% ± 5%	Explore
astrocyte	5 studies	30% ± 9%	Explore
alveolar macrophage	5 studies	32% ± 13%	Explore
exhausted T cell	4 studies	29% ± 9%	Explore
immature B cell	4 studies	28% ± 4%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	27% ± 6%	Explore
myofibroblast cell	4 studies	19% ± 3%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	26% ± 7%	Explore
granulocyte	4 studies	24% ± 3%	Explore
luminal cell of prostate epithelium	4 studies	22% ± 6%	Explore
GABAergic neuron	4 studies	25% ± 5%	Explore
glutamatergic neuron	4 studies	27% ± 3%	Explore
oligodendrocyte precursor cell	4 studies	22% ± 4%	Explore
T-helper 17 cell	4 studies	26% ± 6%	Explore
squamous epithelial cell	3 studies	41% ± 22%	Explore
endothelial cell of artery	3 studies	25% ± 5%	Explore
glial cell	3 studies	22% ± 10%	Explore
progenitor cell	3 studies	27% ± 7%	Explore
brush cell	3 studies	26% ± 9%	Explore
mesothelial cell	3 studies	18% ± 2%	Explore
tissue-resident macrophage	3 studies	29% ± 10%	Explore
germinal center B cell	3 studies	24% ± 2%	Explore
CD4-positive helper T cell	3 studies	37% ± 14%	Explore
muscle cell	3 studies	21% ± 2%	Explore
pancreatic ductal cell	3 studies	36% ± 18%	Explore
erythrocyte	3 studies	32% ± 17%	Explore
group 3 innate lymphoid cell	3 studies	27% ± 10%	Explore
transit amplifying cell	3 studies	32% ± 21%	Explore
keratinocyte	3 studies	40% ± 12%	Explore
interneuron	3 studies	26% ± 1%	Explore
neuron	3 studies	25% ± 7%	Explore
T-helper 1 cell	3 studies	28% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	28% ± 6%	Explore
progenitor cell of mammary luminal epithelium	3 studies	27% ± 7%	Explore
mucus secreting cell	3 studies	21% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	16 studies	25% ± 6%	Explore
peripheral blood	14 studies	29% ± 9%	Explore
brain	9 studies	22% ± 5%	Explore
liver	6 studies	30% ± 17%	Explore
bone marrow	4 studies	22% ± 3%	Explore
breast	4 studies	27% ± 9%	Explore
prostate	4 studies	28% ± 8%	Explore
lymph node	4 studies	24% ± 5%	Explore
intestine	4 studies	20% ± 5%	Explore
adipose	4 studies	22% ± 2%	Explore
kidney	3 studies	22% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	4177.96	578 / 578	100%	36.23	1155 / 1155
esophagus	100%	2606.06	1444 / 1445	100%	55.35	183 / 183
breast	100%	3081.85	459 / 459	100%	33.17	1114 / 1118
bladder	100%	2525.81	21 / 21	99%	27.03	499 / 504
prostate	100%	2496.04	245 / 245	99%	20.11	497 / 502
uterus	100%	1994.81	170 / 170	99%	31.47	454 / 459
ovary	100%	2043.82	180 / 180	98%	17.44	423 / 430
intestine	100%	2474.21	965 / 966	98%	24.20	517 / 527
stomach	100%	1791.05	358 / 359	98%	27.25	281 / 286
thymus	100%	2250.57	653 / 653	97%	15.63	589 / 605
skin	100%	4436.69	1809 / 1809	91%	18.56	431 / 472
pancreas	92%	1113.07	302 / 328	96%	21.25	170 / 178
kidney	90%	1235.02	80 / 89	88%	12.98	793 / 901
liver	98%	1309.17	222 / 226	66%	7.06	269 / 406
adrenal gland	100%	1528.80	258 / 258	39%	3.18	90 / 230
brain	43%	361.86	1141 / 2642	92%	12.40	652 / 705
adipose	100%	3270.80	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	35.13	29 / 29
spleen	100%	5424.22	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	31.13	45 / 45
ureter	0%	0	0 / 0	100%	10.39	1 / 1
peripheral blood	99%	7233.68	920 / 929	0%	0	0 / 0
blood vessel	99%	1672.50	1322 / 1335	0%	0	0 / 0
muscle	92%	1392.11	736 / 803	0%	0	0 / 0
heart	81%	829.40	696 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	45%	4.88	36 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0031445	Biological process	regulation of heterochromatin formation
GO_0006275	Biological process	regulation of DNA replication
GO_0045740	Biological process	positive regulation of DNA replication
GO_0006338	Biological process	chromatin remodeling
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0006261	Biological process	DNA-templated DNA replication
GO_0006334	Biological process	nucleosome assembly
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0008623	Cellular component	CHRAC
GO_0016590	Cellular component	ACF complex
GO_0005634	Cellular component	nucleus
GO_0005721	Cellular component	pericentric heterochromatin
GO_0000228	Cellular component	nuclear chromosome
GO_0003677	Molecular function	DNA binding
GO_0004402	Molecular function	histone acetyltransferase activity
GO_0005515	Molecular function	protein binding
GO_0046872	Molecular function	metal ion binding

IV. Literature review

[source]

Gene name	BAZ1A
Protein name	Bromodomain adjacent to zinc finger domain protein 1A (ATP-dependent chromatin-remodeling protein) (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (CHRAC subunit ACF1) (Williams syndrome transcription factor-related chromatin-remodeling factor 180) (WCRF180) (hWALp1) Bromodomain adjacent to zinc finger domain 1A BAZ1A protein
Synonyms	WCRF180 ACF1 HSPC317
Description	FUNCTION: Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair . Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner . The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex . Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex . Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase . May have a role in nuclear receptor-mediated transcription repression . .
Accessions	ENST00000554865.1 Q9NRL2 Q32ND1 ENST00000553573.1 A0A087WWN7 ENST00000358716.8 [Q9NRL2-2] ENST00000382422.6 [Q9NRL2-1] H0YJP5 ENST00000556314.2 H0YJ68 ENST00000555331.1 Q05CW0 ENST00000360310.6 [Q9NRL2-1] H0YJ74

BAZ1A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review