ARPP19 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	27 studies	27% ± 11%	Explore
B cell	19 studies	21% ± 7%	Explore
natural killer cell	18 studies	22% ± 5%	Explore
smooth muscle cell	17 studies	23% ± 4%	Explore
pericyte	16 studies	20% ± 3%	Explore
regulatory T cell	15 studies	22% ± 5%	Explore
CD8-positive, alpha-beta T cell	13 studies	19% ± 4%	Explore
T cell	12 studies	22% ± 5%	Explore
macrophage	11 studies	23% ± 6%	Explore
basal cell	11 studies	29% ± 9%	Explore
CD4-positive, alpha-beta T cell	10 studies	20% ± 3%	Explore
fibroblast	10 studies	24% ± 6%	Explore
oligodendrocyte	10 studies	25% ± 6%	Explore
glutamatergic neuron	10 studies	53% ± 21%	Explore
epithelial cell	10 studies	37% ± 17%	Explore
conventional dendritic cell	9 studies	22% ± 8%	Explore
mature NK T cell	9 studies	20% ± 5%	Explore
naive B cell	8 studies	23% ± 4%	Explore
capillary endothelial cell	8 studies	18% ± 2%	Explore
astrocyte	8 studies	23% ± 9%	Explore
gamma-delta T cell	8 studies	24% ± 12%	Explore
type I pneumocyte	7 studies	25% ± 9%	Explore
CD16-positive, CD56-dim natural killer cell, human	7 studies	20% ± 3%	Explore
connective tissue cell	7 studies	20% ± 5%	Explore
neuron	7 studies	40% ± 16%	Explore
endothelial cell of artery	7 studies	23% ± 3%	Explore
memory B cell	7 studies	21% ± 4%	Explore
ciliated cell	7 studies	31% ± 11%	Explore
endothelial cell of vascular tree	7 studies	22% ± 4%	Explore
oligodendrocyte precursor cell	7 studies	24% ± 8%	Explore
endothelial cell of lymphatic vessel	6 studies	21% ± 5%	Explore
vein endothelial cell	6 studies	20% ± 6%	Explore
GABAergic neuron	6 studies	34% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	23% ± 4%	Explore
secretory cell	6 studies	29% ± 9%	Explore
mast cell	5 studies	22% ± 9%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	22% ± 3%	Explore
leukocyte	5 studies	24% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	20% ± 1%	Explore
kidney loop of Henle epithelial cell	5 studies	21% ± 1%	Explore
myofibroblast cell	5 studies	20% ± 4%	Explore
retinal cone cell	5 studies	40% ± 21%	Explore
interneuron	5 studies	25% ± 7%	Explore
pancreatic A cell	4 studies	59% ± 11%	Explore
type B pancreatic cell	4 studies	61% ± 15%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	21% ± 3%	Explore
non-classical monocyte	4 studies	23% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	25% ± 6%	Explore
exhausted T cell	4 studies	22% ± 5%	Explore
retinal ganglion cell	4 studies	69% ± 28%	Explore
innate lymphoid cell	4 studies	21% ± 4%	Explore
myeloid cell	4 studies	28% ± 9%	Explore
club cell	4 studies	26% ± 10%	Explore
amacrine cell	4 studies	36% ± 14%	Explore
retina horizontal cell	4 studies	31% ± 15%	Explore
retinal rod cell	4 studies	23% ± 6%	Explore
mucosal invariant T cell	4 studies	17% ± 1%	Explore
T follicular helper cell	4 studies	17% ± 2%	Explore
abnormal cell	4 studies	28% ± 11%	Explore
dendritic cell	4 studies	44% ± 12%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	32% ± 10%	Explore
enteroendocrine cell	4 studies	29% ± 16%	Explore
goblet cell	4 studies	24% ± 7%	Explore
plasmacytoid dendritic cell	4 studies	24% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	22% ± 4%	Explore
pancreatic D cell	3 studies	56% ± 17%	Explore
classical monocyte	3 studies	24% ± 4%	Explore
hematopoietic precursor cell	3 studies	30% ± 16%	Explore
plasmablast	3 studies	34% ± 14%	Explore
glomerular endothelial cell	3 studies	20% ± 2%	Explore
podocyte	3 studies	34% ± 5%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	27% ± 2%	Explore
epithelial cell of proximal tubule	3 studies	20% ± 3%	Explore
plasma cell	3 studies	34% ± 10%	Explore
brush cell	3 studies	29% ± 8%	Explore
precursor B cell	3 studies	32% ± 10%	Explore
pro-B cell	3 studies	28% ± 5%	Explore
lymphocyte	3 studies	25% ± 10%	Explore
Mueller cell	3 studies	29% ± 5%	Explore
rod bipolar cell	3 studies	25% ± 6%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	24% ± 4%	Explore
luminal cell of prostate epithelium	3 studies	27% ± 9%	Explore
muscle cell	3 studies	26% ± 6%	Explore
pancreatic ductal cell	3 studies	55% ± 14%	Explore
intestinal crypt stem cell	3 studies	18% ± 2%	Explore
group 3 innate lymphoid cell	3 studies	27% ± 13%	Explore
transit amplifying cell	3 studies	27% ± 12%	Explore
microglial cell	3 studies	19% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	13 studies	35% ± 16%	Explore
lung	9 studies	25% ± 8%	Explore
eye	7 studies	26% ± 9%	Explore
kidney	6 studies	18% ± 3%	Explore
pancreas	4 studies	53% ± 16%	Explore
peripheral blood	4 studies	27% ± 4%	Explore
uterus	4 studies	24% ± 13%	Explore
intestine	3 studies	23% ± 9%	Explore
breast	3 studies	20% ± 2%	Explore
bone marrow	3 studies	17% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	25709.43	2642 / 2642	100%	153.91	705 / 705
breast	100%	8211.05	459 / 459	100%	104.49	1118 / 1118
esophagus	100%	8319.73	1445 / 1445	100%	114.72	183 / 183
lung	100%	8533.41	577 / 578	100%	83.47	1155 / 1155
ovary	100%	6455.61	180 / 180	100%	57.09	429 / 430
kidney	100%	7531.53	89 / 89	100%	80.88	897 / 901
thymus	100%	8052.39	652 / 653	100%	83.92	602 / 605
uterus	100%	7642.68	170 / 170	99%	75.88	456 / 459
prostate	100%	5987.24	244 / 245	100%	55.25	500 / 502
bladder	100%	7422.71	21 / 21	99%	65.90	497 / 504
intestine	100%	8021.29	966 / 966	98%	60.41	516 / 527
stomach	99%	5453.28	357 / 359	98%	68.16	281 / 286
adrenal gland	100%	7632.84	258 / 258	96%	82.73	221 / 230
skin	100%	7236.63	1803 / 1809	96%	87.28	454 / 472
pancreas	92%	3220.11	303 / 328	98%	65.45	175 / 178
liver	92%	2868.51	208 / 226	92%	35.31	372 / 406
adipose	100%	8926.90	1204 / 1204	0%	0	0 / 0
blood vessel	100%	9775.96	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	52.55	29 / 29
muscle	100%	11897.21	803 / 803	0%	0	0 / 0
spleen	100%	5666.59	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	76.44	45 / 45
ureter	0%	0	0 / 0	100%	38.58	1 / 1
heart	94%	5464.39	809 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	91%	45.74	73 / 80
peripheral blood	74%	4894.34	692 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000086	Biological process	G2/M transition of mitotic cell cycle
GO_0045722	Biological process	positive regulation of gluconeogenesis
GO_0046326	Biological process	positive regulation of glucose import
GO_0051301	Biological process	cell division
GO_0000278	Biological process	mitotic cell cycle
GO_0035308	Biological process	negative regulation of protein dephosphorylation
GO_0005654	Cellular component	nucleoplasm
GO_0005737	Cellular component	cytoplasm
GO_0004864	Molecular function	protein phosphatase inhibitor activity
GO_0051721	Molecular function	protein phosphatase 2A binding
GO_0019888	Molecular function	protein phosphatase regulator activity
GO_0005102	Molecular function	signaling receptor binding
GO_0005515	Molecular function	protein binding
GO_0015459	Molecular function	potassium channel regulator activity
GO_0019212	Molecular function	phosphatase inhibitor activity

IV. Literature review

[source]

Gene name	ARPP19
Protein name	cAMP-regulated phosphoprotein 19 (ARPP-19) cAMP regulated phosphoprotein 19 cAMP-regulated phosphoprotein 19
Synonyms
Description	FUNCTION: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression. . FUNCTION: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. . FUNCTION: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. . FUNCTION: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. .
Accessions	H3BTD3 ENST00000563277.5 [P56211-2] ENST00000249822.9 [P56211-1] ENST00000566423.5 [P56211-1] ENST00000564163.5 ENST00000567830.1 ENST00000561650.5 [P56211-2] ENST00000569723.5 H3BMD8 ENST00000561971.1 ENST00000569281.6 [P56211-1] ENST00000563566.5 [P56211-2] P56211 ENST00000567669.5 [P56211-1] ENST00000568196.1 [P56211-2] H3BQ52

ARPP19 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review