ARID1A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030071Biological processregulation of mitotic metaphase/anaphase transition
GO_0045582Biological processpositive regulation of T cell differentiation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_2000045Biological processregulation of G1/S transition of mitotic cell cycle
GO_0045663Biological processpositive regulation of myoblast differentiation
GO_0006338Biological processchromatin remodeling
GO_0042921Biological processnuclear receptor-mediated glucocorticoid signaling pathway
GO_0070316Biological processregulation of G0 to G1 transition
GO_1902459Biological processpositive regulation of stem cell population maintenance
GO_0045597Biological processpositive regulation of cell differentiation
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_2000819Biological processregulation of nucleotide-excision repair
GO_0006337Biological processnucleosome disassembly
GO_0030521Biological processandrogen receptor signaling pathway
GO_2000781Biological processpositive regulation of double-strand break repair
GO_0030520Biological processestrogen receptor signaling pathway
GO_0007399Biological processnervous system development
GO_0045815Biological processtranscription initiation-coupled chromatin remodeling
GO_0071565Cellular componentnBAF complex
GO_0071564Cellular componentnpBAF complex
GO_0016514Cellular componentSWI/SNF complex
GO_0005654Cellular componentnucleoplasm
GO_0035060Cellular componentbrahma complex
GO_0000785Cellular componentchromatin
GO_0140092Cellular componentbBAF complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0016922Molecular functionnuclear receptor binding
GO_0031491Molecular functionnucleosome binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameARID1A
Protein nameAT-rich interaction domain 1A
AT-rich interactive domain-containing protein 1A
ARID1A variant protein
AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD)
ARID1A protein
ARID1A
SynonymsC1orf4
SMARCF1
protein
BAF250
variant
OSA1
BAF250A
DescriptionFUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). .

AccessionsA0A1B0GVT5
H0YEW5
ENST00000430799.7
ENST00000374152.7 [O14497-3]
E9PQW6
H0Y488
Q4LE49
ENST00000324856.13 [O14497-1]
A4FU79
ENST00000457599.6 [O14497-2]
ENST00000532781.1
ENST00000637465.1
H0YCU6
A0A0S2Q0B1
ENST00000524572.1
ENST00000466382.2
A0A1B0GTU5
C1KEN7
ENST00000636219.1
O14497