ARHGDIB report

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I. Expression across cell types

Cell ontologyData table

Name	Number of supported studies	Average coverage
B cell	47 studies	67% ± 22%	Explore
natural killer cell	45 studies	76% ± 19%	Explore
macrophage	44 studies	60% ± 24%	Explore
CD8-positive, alpha-beta T cell	41 studies	75% ± 21%	Explore
T cell	40 studies	68% ± 25%	Explore
CD4-positive, alpha-beta T cell	35 studies	78% ± 22%	Explore
mast cell	31 studies	60% ± 26%	Explore
conventional dendritic cell	29 studies	83% ± 14%	Explore
classical monocyte	28 studies	73% ± 20%	Explore
regulatory T cell	28 studies	87% ± 12%	Explore
endothelial cell	26 studies	41% ± 16%	Explore
monocyte	25 studies	65% ± 24%	Explore
dendritic cell	24 studies	62% ± 29%	Explore
non-classical monocyte	24 studies	85% ± 13%	Explore
pericyte	23 studies	44% ± 22%	Explore
mature NK T cell	22 studies	77% ± 18%	Explore
plasmacytoid dendritic cell	22 studies	64% ± 18%	Explore
gamma-delta T cell	20 studies	79% ± 19%	Explore
memory B cell	20 studies	81% ± 12%	Explore
naive B cell	19 studies	76% ± 12%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	19 studies	76% ± 21%	Explore
CD16-negative, CD56-bright natural killer cell, human	17 studies	72% ± 23%	Explore
mucosal invariant T cell	16 studies	81% ± 14%	Explore
plasma cell	16 studies	53% ± 19%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	15 studies	86% ± 16%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	85% ± 13%	Explore
neutrophil	15 studies	55% ± 21%	Explore
myeloid cell	15 studies	66% ± 23%	Explore
effector memory CD8-positive, alpha-beta T cell	13 studies	73% ± 23%	Explore
innate lymphoid cell	13 studies	71% ± 18%	Explore
CD4-positive, alpha-beta memory T cell	13 studies	79% ± 18%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	82% ± 17%	Explore
plasmablast	12 studies	68% ± 23%	Explore
platelet	11 studies	72% ± 19%	Explore
leukocyte	11 studies	58% ± 24%	Explore
capillary endothelial cell	11 studies	36% ± 11%	Explore
endothelial cell of artery	11 studies	35% ± 17%	Explore
T follicular helper cell	10 studies	82% ± 12%	Explore
vein endothelial cell	10 studies	38% ± 14%	Explore
microglial cell	9 studies	39% ± 23%	Explore
smooth muscle cell	8 studies	37% ± 21%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	85% ± 13%	Explore
hematopoietic stem cell	8 studies	91% ± 7%	Explore
fibroblast	8 studies	31% ± 17%	Explore
precursor B cell	7 studies	77% ± 24%	Explore
endothelial cell of vascular tree	7 studies	38% ± 20%	Explore
alveolar macrophage	6 studies	60% ± 18%	Explore
CD4-positive helper T cell	6 studies	76% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	71% ± 25%	Explore
hematopoietic precursor cell	6 studies	77% ± 26%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	88% ± 15%	Explore
mononuclear phagocyte	6 studies	65% ± 24%	Explore
myofibroblast cell	6 studies	41% ± 24%	Explore
megakaryocyte	6 studies	71% ± 28%	Explore
immature B cell	6 studies	88% ± 8%	Explore
intermediate monocyte	6 studies	74% ± 26%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	88% ± 9%	Explore
granulocyte	6 studies	74% ± 15%	Explore
erythrocyte	6 studies	52% ± 15%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	83% ± 9%	Explore
exhausted T cell	5 studies	89% ± 6%	Explore
respiratory goblet cell	5 studies	30% ± 12%	Explore
secretory cell	5 studies	31% ± 18%	Explore
lymphocyte	5 studies	50% ± 27%	Explore
pro-B cell	5 studies	84% ± 20%	Explore
T-helper 17 cell	5 studies	88% ± 11%	Explore
group 3 innate lymphoid cell	5 studies	89% ± 8%	Explore
double negative thymocyte	5 studies	95% ± 3%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	74% ± 25%	Explore
epithelial cell	4 studies	30% ± 9%	Explore
glomerular endothelial cell	4 studies	62% ± 10%	Explore
IgG plasma cell	4 studies	31% ± 20%	Explore
erythroblast	4 studies	51% ± 22%	Explore
inflammatory macrophage	4 studies	58% ± 17%	Explore
germinal center B cell	4 studies	83% ± 11%	Explore
basal cell	4 studies	33% ± 10%	Explore
T-helper 1 cell	4 studies	91% ± 8%	Explore
squamous epithelial cell	3 studies	37% ± 12%	Explore
monocyte-derived dendritic cell	3 studies	71% ± 30%	Explore
thymocyte	3 studies	71% ± 20%	Explore
extravillous trophoblast	3 studies	73% ± 12%	Explore
club cell	3 studies	31% ± 19%	Explore
tissue-resident macrophage	3 studies	56% ± 25%	Explore
follicular B cell	3 studies	70% ± 16%	Explore
intraepithelial lymphocyte	3 studies	89% ± 6%	Explore
IgM plasma cell	3 studies	49% ± 20%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	95% ± 6%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	92% ± 4%	Explore
double-positive, alpha-beta thymocyte	3 studies	97% ± 2%	Explore
abnormal cell	3 studies	57% ± 27%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	40% ± 11%	Explore

II. Expression across tissues

sc-RNAseq dataData table

Name	Number of supported studies	Average coverage
peripheral blood	21 studies	79% ± 17%	Explore
lung	14 studies	42% ± 17%	Explore
kidney	6 studies	45% ± 27%	Explore
bone marrow	6 studies	56% ± 26%	Explore
intestine	5 studies	39% ± 12%	Explore
lymph node	5 studies	70% ± 17%	Explore
liver	5 studies	51% ± 19%	Explore
breast	4 studies	35% ± 15%	Explore
placenta	3 studies	46% ± 12%	Explore
adrenal gland	3 studies	45% ± 27%	Explore
thymus	3 studies	71% ± 31%	Explore
brain	3 studies	52% ± 14%	Explore

Bulk RNAseq dataData table

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	6475.72	653 / 653	99%	484.76	601 / 605
breast	100%	7984.57	459 / 459	99%	470.46	1108 / 1118
lung	100%	11615.75	578 / 578	95%	276.01	1103 / 1155
bladder	100%	5208.43	21 / 21	95%	284.04	478 / 504
uterus	99%	3947.56	169 / 170	93%	188.23	426 / 459
kidney	98%	4641.76	87 / 89	92%	303.23	825 / 901
intestine	91%	4624.14	881 / 966	88%	145.33	465 / 527
prostate	97%	3955.95	238 / 245	82%	120.78	410 / 502
skin	89%	3053.35	1603 / 1809	86%	214.81	406 / 472
stomach	81%	2186.74	289 / 359	90%	152.24	257 / 286
esophagus	93%	2988.68	1349 / 1445	76%	90.68	139 / 183
adrenal gland	95%	3318.66	246 / 258	72%	96.15	166 / 230
ovary	41%	1054.01	74 / 180	81%	104.19	349 / 430
brain	36%	847.56	941 / 2642	85%	153.04	601 / 705
pancreas	22%	489.11	72 / 328	97%	264.31	172 / 178
liver	54%	1317.39	122 / 226	64%	79.04	260 / 406
adipose	100%	9299.23	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	1327.05	29 / 29
peripheral blood	100%	85484.34	929 / 929	0%	0	0 / 0
spleen	100%	31347.00	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	282.45	1 / 1
heart	97%	3562.88	831 / 861	0%	0	0 / 0
blood vessel	96%	6148.28	1283 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	91%	224.85	41 / 45
muscle	49%	967.73	390 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	33%	31.90	26 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0