WIPF1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	43 studies	47% ± 14%	Explore
CD8-positive, alpha-beta T cell	38 studies	40% ± 12%	Explore
T cell	36 studies	38% ± 13%	Explore
macrophage	36 studies	33% ± 15%	Explore
B cell	34 studies	31% ± 8%	Explore
CD4-positive, alpha-beta T cell	33 studies	36% ± 10%	Explore
regulatory T cell	28 studies	41% ± 11%	Explore
classical monocyte	23 studies	29% ± 9%	Explore
mature NK T cell	22 studies	44% ± 13%	Explore
monocyte	20 studies	30% ± 10%	Explore
memory B cell	20 studies	32% ± 9%	Explore
naive B cell	19 studies	28% ± 8%	Explore
non-classical monocyte	19 studies	30% ± 11%	Explore
conventional dendritic cell	19 studies	25% ± 10%	Explore
dendritic cell	18 studies	36% ± 14%	Explore
gamma-delta T cell	17 studies	48% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	50% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	54% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	16 studies	32% ± 7%	Explore
mast cell	15 studies	24% ± 9%	Explore
oligodendrocyte	15 studies	39% ± 15%	Explore
mucosal invariant T cell	15 studies	47% ± 11%	Explore
myeloid cell	14 studies	36% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	52% ± 14%	Explore
endothelial cell	13 studies	26% ± 6%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	40% ± 8%	Explore
oligodendrocyte precursor cell	12 studies	38% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	51% ± 11%	Explore
microglial cell	12 studies	40% ± 18%	Explore
fibroblast	12 studies	21% ± 5%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	43% ± 11%	Explore
platelet	10 studies	37% ± 11%	Explore
plasma cell	9 studies	24% ± 11%	Explore
neutrophil	9 studies	28% ± 7%	Explore
leukocyte	9 studies	40% ± 17%	Explore
plasmablast	8 studies	35% ± 18%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	43% ± 14%	Explore
T follicular helper cell	8 studies	46% ± 7%	Explore
innate lymphoid cell	8 studies	36% ± 12%	Explore
mononuclear phagocyte	7 studies	31% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	42% ± 13%	Explore
plasmacytoid dendritic cell	6 studies	24% ± 8%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	44% ± 13%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	41% ± 11%	Explore
exhausted T cell	5 studies	57% ± 12%	Explore
lymphocyte	5 studies	52% ± 18%	Explore
double negative thymocyte	5 studies	56% ± 14%	Explore
CD4-positive helper T cell	5 studies	39% ± 16%	Explore
endothelial cell of lymphatic vessel	5 studies	29% ± 6%	Explore
hematopoietic stem cell	5 studies	31% ± 16%	Explore
pericyte	5 studies	21% ± 6%	Explore
smooth muscle cell	5 studies	20% ± 2%	Explore
hematopoietic precursor cell	4 studies	32% ± 11%	Explore
megakaryocyte	4 studies	38% ± 13%	Explore
immature B cell	4 studies	22% ± 4%	Explore
glial cell	4 studies	25% ± 9%	Explore
alveolar macrophage	4 studies	31% ± 14%	Explore
T-helper 17 cell	4 studies	44% ± 12%	Explore
T-helper 1 cell	4 studies	50% ± 7%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	44% ± 19%	Explore
GABAergic neuron	3 studies	20% ± 4%	Explore
pro-B cell	3 studies	22% ± 7%	Explore
tissue-resident macrophage	3 studies	42% ± 10%	Explore
germinal center B cell	3 studies	49% ± 9%	Explore
intermediate monocyte	3 studies	44% ± 26%	Explore
group 3 innate lymphoid cell	3 studies	41% ± 8%	Explore
Schwann cell	3 studies	43% ± 23%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	35% ± 11%	Explore
astrocyte	3 studies	34% ± 4%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	42% ± 17%	Explore
abnormal cell	3 studies	25% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	17 studies	35% ± 9%	Explore
lung	9 studies	24% ± 7%	Explore
brain	8 studies	28% ± 16%	Explore
adipose	5 studies	26% ± 5%	Explore
lymph node	4 studies	34% ± 6%	Explore
bone marrow	3 studies	36% ± 7%	Explore
intestine	3 studies	24% ± 4%	Explore
liver	3 studies	27% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	99%	3419.84	649 / 653	99%	23.83	600 / 605
kidney	100%	2170.91	89 / 89	98%	29.50	880 / 901
lung	100%	5865.99	577 / 578	97%	23.67	1122 / 1155
breast	100%	4491.10	459 / 459	97%	25.79	1083 / 1118
uterus	100%	4019.69	170 / 170	88%	16.17	404 / 459
skin	90%	2703.34	1626 / 1809	96%	58.35	452 / 472
intestine	99%	5095.11	958 / 966	81%	13.94	426 / 527
prostate	99%	2977.78	242 / 245	80%	9.60	401 / 502
ovary	96%	1892.17	172 / 180	82%	10.99	353 / 430
bladder	100%	4066.76	21 / 21	75%	12.85	380 / 504
adrenal gland	92%	1683.29	237 / 258	83%	11.72	191 / 230
esophagus	84%	2946.44	1212 / 1445	90%	18.12	165 / 183
brain	65%	2096.80	1722 / 2642	100%	25.29	702 / 705
stomach	77%	2048.31	277 / 359	85%	18.84	243 / 286
pancreas	20%	278.62	66 / 328	96%	26.25	170 / 178
adipose	100%	5487.74	1204 / 1204	0%	0	0 / 0
blood vessel	100%	7532.02	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	109.85	29 / 29
peripheral blood	100%	20670.65	929 / 929	0%	0	0 / 0
spleen	100%	11953.55	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	23.07	42 / 45
heart	82%	1718.14	706 / 861	0%	0	0 / 0
liver	23%	301.21	51 / 226	43%	5.58	176 / 406
eye	0%	0	0 / 0	33%	3.30	26 / 80
muscle	14%	193.45	115 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006457	Biological process	protein folding
GO_0008154	Biological process	actin polymerization or depolymerization
GO_0051707	Biological process	response to other organism
GO_0030048	Biological process	actin filament-based movement
GO_0065003	Biological process	protein-containing complex assembly
GO_0001726	Cellular component	ruffle
GO_0015629	Cellular component	actin cytoskeleton
GO_0005829	Cellular component	cytosol
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0005884	Cellular component	actin filament
GO_0044183	Molecular function	protein folding chaperone
GO_0017124	Molecular function	SH3 domain binding
GO_0005515	Molecular function	protein binding
GO_0003779	Molecular function	actin binding
GO_0005522	Molecular function	profilin binding

IV. Literature review

[source]

Gene name	WIPF1
Protein name	WIPF1 protein WAS/WASL interacting protein family member 1 WAS/WASL-interacting protein family member 1 (Protein PRPL-2) (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein) WAS/WASL-interacting protein family member 1
Synonyms	WASPIP WIP
Description	FUNCTION: Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus. .
Accessions	ENST00000436221.1 ENST00000698667.1 C9JTB9 ENST00000698668.1 [O43516-1] ENST00000679041.1 [O43516-1] ENST00000436221.2 [O43516-1] ENST00000359761.7 [O43516-1] ENST00000409891.5 [O43516-2] E9PB87 ENST00000409415.7 ENST00000455428.5 ENST00000392547.6 [O43516-1] ENST00000272746.9 [O43516-3] A0A8V8TNJ8 ENST00000392546.6 [O43516-1] O43516 Q2YDC4 ENST00000698701.1 [O43516-1] C9JB04

WIPF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review