WDR1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	36 studies	36% ± 15%	Explore
macrophage	34 studies	28% ± 12%	Explore
CD8-positive, alpha-beta T cell	31 studies	37% ± 18%	Explore
endothelial cell	29 studies	27% ± 10%	Explore
CD4-positive, alpha-beta T cell	27 studies	35% ± 18%	Explore
smooth muscle cell	26 studies	36% ± 14%	Explore
T cell	25 studies	35% ± 16%	Explore
regulatory T cell	25 studies	39% ± 17%	Explore
non-classical monocyte	24 studies	43% ± 16%	Explore
conventional dendritic cell	23 studies	38% ± 14%	Explore
classical monocyte	22 studies	34% ± 11%	Explore
pericyte	22 studies	29% ± 9%	Explore
dendritic cell	20 studies	40% ± 20%	Explore
B cell	19 studies	29% ± 11%	Explore
monocyte	19 studies	31% ± 10%	Explore
mature NK T cell	19 studies	34% ± 11%	Explore
plasmacytoid dendritic cell	19 studies	40% ± 14%	Explore
fibroblast	19 studies	22% ± 9%	Explore
basal cell	18 studies	27% ± 11%	Explore
memory B cell	16 studies	25% ± 8%	Explore
epithelial cell	16 studies	34% ± 18%	Explore
gamma-delta T cell	15 studies	38% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	44% ± 14%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	35% ± 12%	Explore
capillary endothelial cell	12 studies	25% ± 10%	Explore
naive B cell	12 studies	23% ± 6%	Explore
platelet	11 studies	47% ± 18%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	38% ± 17%	Explore
ciliated cell	11 studies	32% ± 12%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	33% ± 9%	Explore
myofibroblast cell	11 studies	33% ± 13%	Explore
vein endothelial cell	11 studies	25% ± 7%	Explore
myeloid cell	11 studies	34% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	38% ± 17%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	28% ± 7%	Explore
endothelial cell of artery	10 studies	24% ± 7%	Explore
endothelial cell of vascular tree	10 studies	25% ± 6%	Explore
plasmablast	9 studies	34% ± 22%	Explore
connective tissue cell	9 studies	27% ± 8%	Explore
goblet cell	9 studies	25% ± 9%	Explore
mucosal invariant T cell	9 studies	36% ± 5%	Explore
plasma cell	8 studies	31% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	33% ± 12%	Explore
endothelial cell of lymphatic vessel	8 studies	26% ± 8%	Explore
alveolar macrophage	7 studies	25% ± 4%	Explore
secretory cell	7 studies	28% ± 8%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	43% ± 24%	Explore
innate lymphoid cell	7 studies	24% ± 9%	Explore
T follicular helper cell	7 studies	33% ± 8%	Explore
abnormal cell	7 studies	24% ± 8%	Explore
mononuclear phagocyte	6 studies	28% ± 15%	Explore
renal alpha-intercalated cell	6 studies	43% ± 7%	Explore
megakaryocyte	6 studies	69% ± 20%	Explore
transit amplifying cell	6 studies	23% ± 8%	Explore
hematopoietic stem cell	6 studies	33% ± 21%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	34% ± 13%	Explore
hematopoietic precursor cell	5 studies	36% ± 14%	Explore
exhausted T cell	5 studies	51% ± 12%	Explore
ionocyte	5 studies	40% ± 13%	Explore
neutrophil	5 studies	21% ± 3%	Explore
leukocyte	5 studies	28% ± 11%	Explore
kidney loop of Henle epithelial cell	5 studies	21% ± 5%	Explore
precursor B cell	5 studies	32% ± 9%	Explore
enterocyte	5 studies	22% ± 6%	Explore
respiratory goblet cell	4 studies	32% ± 15%	Explore
squamous epithelial cell	4 studies	44% ± 20%	Explore
progenitor cell	4 studies	21% ± 3%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	26% ± 9%	Explore
microglial cell	4 studies	22% ± 7%	Explore
lymphocyte	4 studies	34% ± 15%	Explore
pro-B cell	4 studies	28% ± 8%	Explore
type I pneumocyte	4 studies	28% ± 9%	Explore
double negative thymocyte	4 studies	54% ± 9%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	65% ± 9%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	51% ± 17%	Explore
brush cell	4 studies	24% ± 8%	Explore
T-helper 17 cell	4 studies	36% ± 24%	Explore
CD4-positive helper T cell	3 studies	21% ± 8%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	46% ± 23%	Explore
club cell	3 studies	27% ± 7%	Explore
pancreatic A cell	3 studies	39% ± 4%	Explore
glomerular endothelial cell	3 studies	22% ± 1%	Explore
immature B cell	3 studies	35% ± 10%	Explore
retinal cone cell	3 studies	44% ± 11%	Explore
intraepithelial lymphocyte	3 studies	36% ± 19%	Explore
Mueller cell	3 studies	26% ± 3%	Explore
melanocyte	3 studies	22% ± 5%	Explore
germinal center B cell	3 studies	45% ± 11%	Explore
intermediate monocyte	3 studies	51% ± 18%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	23% ± 2%	Explore
muscle cell	3 studies	44% ± 20%	Explore
pancreatic ductal cell	3 studies	59% ± 25%	Explore
oligodendrocyte precursor cell	3 studies	24% ± 7%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	41% ± 23%	Explore
enteroendocrine cell	3 studies	33% ± 6%	Explore
group 3 innate lymphoid cell	3 studies	35% ± 12%	Explore
T-helper 1 cell	3 studies	49% ± 23%	Explore
mast cell	3 studies	24% ± 8%	Explore
erythrocyte	3 studies	29% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	16 studies	35% ± 8%	Explore
lung	14 studies	28% ± 9%	Explore
kidney	7 studies	25% ± 9%	Explore
intestine	7 studies	24% ± 8%	Explore
bone marrow	4 studies	24% ± 10%	Explore
eye	4 studies	23% ± 7%	Explore
uterus	4 studies	29% ± 13%	Explore
lymph node	4 studies	32% ± 4%	Explore
pancreas	3 studies	39% ± 8%	Explore
placenta	3 studies	26% ± 10%	Explore
skin	3 studies	17% ± 1%	Explore
breast	3 studies	22% ± 2%	Explore
liver	3 studies	29% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	29995.14	1445 / 1445	100%	130.20	183 / 183
ovary	100%	17465.51	180 / 180	100%	105.31	430 / 430
stomach	100%	15866.35	359 / 359	100%	160.35	286 / 286
kidney	100%	16282.91	89 / 89	100%	128.24	900 / 901
lung	100%	21701.95	577 / 578	100%	135.68	1155 / 1155
breast	100%	17051.06	459 / 459	100%	152.35	1116 / 1118
intestine	100%	26636.11	966 / 966	100%	171.86	526 / 527
skin	100%	21022.08	1808 / 1809	100%	204.22	471 / 472
thymus	100%	18081.47	652 / 653	100%	180.89	604 / 605
bladder	100%	29694.71	21 / 21	100%	158.73	502 / 504
uterus	100%	33819.68	170 / 170	100%	160.98	457 / 459
prostate	100%	19880.87	244 / 245	100%	113.24	501 / 502
adrenal gland	99%	10887.70	256 / 258	93%	57.43	213 / 230
liver	76%	5518.62	172 / 226	98%	69.02	398 / 406
brain	74%	5039.15	1945 / 2642	100%	115.97	705 / 705
pancreas	70%	4212.47	228 / 328	99%	150.45	176 / 178
blood vessel	100%	44344.21	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	172.87	80 / 80
lymph node	0%	0	0 / 0	100%	205.09	29 / 29
spleen	100%	16211.27	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	163.27	45 / 45
ureter	0%	0	0 / 0	100%	98.41	1 / 1
adipose	100%	18663.00	1203 / 1204	0%	0	0 / 0
peripheral blood	99%	22881.31	919 / 929	0%	0	0 / 0
muscle	95%	7431.33	762 / 803	0%	0	0 / 0
heart	95%	12484.92	814 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1990266	Biological process	neutrophil migration
GO_0007605	Biological process	sensory perception of sound
GO_0060307	Biological process	regulation of ventricular cardiac muscle cell membrane repolarization
GO_0045199	Biological process	maintenance of epithelial cell apical/basal polarity
GO_0043297	Biological process	apical junction assembly
GO_0030042	Biological process	actin filament depolymerization
GO_0040011	Biological process	locomotion
GO_0030834	Biological process	regulation of actin filament depolymerization
GO_0030865	Biological process	cortical cytoskeleton organization
GO_0042247	Biological process	establishment of planar polarity of follicular epithelium
GO_0002446	Biological process	neutrophil mediated immunity
GO_0030043	Biological process	actin filament fragmentation
GO_0048713	Biological process	regulation of oligodendrocyte differentiation
GO_0045214	Biological process	sarcomere organization
GO_0008360	Biological process	regulation of cell shape
GO_0030836	Biological process	positive regulation of actin filament depolymerization
GO_0030220	Biological process	platelet formation
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0070062	Cellular component	extracellular exosome
GO_0002102	Cellular component	podosome
GO_0030864	Cellular component	cortical actin cytoskeleton
GO_0005911	Cellular component	cell-cell junction
GO_0005829	Cellular component	cytosol
GO_0042995	Cellular component	cell projection
GO_0030054	Cellular component	cell junction
GO_0051015	Molecular function	actin filament binding

IV. Literature review

[source]

Gene name	WDR1
Protein name	WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1) WD repeat domain 1 Alternative protein WDR1 WD repeat domain 1, isoform CRA_a (WD repeat-containing protein 1 isoform 1 variant)
Synonyms	hCG_19377
Description	FUNCTION: Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins . Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions . Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt . .
Accessions	Q53GN4 A0A8V8TQ74 ENST00000264785.12 ENST00000502702.6 [O75083-3] A0A8V8TP31 D6RD66 ENST00000508079.1 ENST00000699798.1 ENST00000699787.1 [O75083-1] A0A8V8TNU2 O75083 ENST00000699788.1 [O75083-3] A0A8V8TQK0 ENST00000699799.1 A0A8V8TNT7 A0A8V8TP22 A0A8V8TPA9 A0A8V8TQ69 ENST00000699794.1 ENST00000699786.1 ENST00000699797.1 ENST00000699795.1 ENST00000699790.1 [O75083-3] L8E9Y5 ENST00000499869.7 [O75083-1] ENST00000699796.1

WDR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review