WAC | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	45 studies	37% ± 17%	Explore
B cell	29 studies	26% ± 11%	Explore
fibroblast	28 studies	32% ± 13%	Explore
macrophage	27 studies	32% ± 17%	Explore
natural killer cell	26 studies	25% ± 9%	Explore
smooth muscle cell	23 studies	27% ± 10%	Explore
pericyte	23 studies	30% ± 15%	Explore
classical monocyte	22 studies	27% ± 12%	Explore
astrocyte	20 studies	39% ± 17%	Explore
non-classical monocyte	19 studies	33% ± 15%	Explore
T cell	18 studies	26% ± 10%	Explore
CD8-positive, alpha-beta T cell	17 studies	24% ± 8%	Explore
oligodendrocyte	16 studies	41% ± 16%	Explore
monocyte	15 studies	33% ± 13%	Explore
oligodendrocyte precursor cell	15 studies	40% ± 19%	Explore
microglial cell	14 studies	48% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	23% ± 8%	Explore
CD4-positive, alpha-beta T cell	13 studies	26% ± 10%	Explore
memory B cell	13 studies	23% ± 10%	Explore
basal cell	13 studies	36% ± 18%	Explore
endothelial cell of vascular tree	13 studies	27% ± 16%	Explore
mast cell	12 studies	28% ± 10%	Explore
endothelial cell of lymphatic vessel	12 studies	35% ± 16%	Explore
naive B cell	12 studies	26% ± 9%	Explore
glutamatergic neuron	12 studies	49% ± 24%	Explore
conventional dendritic cell	12 studies	27% ± 14%	Explore
capillary endothelial cell	12 studies	25% ± 9%	Explore
gamma-delta T cell	12 studies	25% ± 10%	Explore
regulatory T cell	12 studies	25% ± 8%	Explore
myeloid cell	12 studies	34% ± 12%	Explore
GABAergic neuron	11 studies	43% ± 22%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	27% ± 10%	Explore
ciliated cell	11 studies	31% ± 13%	Explore
endothelial cell of artery	10 studies	25% ± 5%	Explore
dendritic cell	10 studies	40% ± 20%	Explore
plasmacytoid dendritic cell	10 studies	23% ± 8%	Explore
epithelial cell	10 studies	47% ± 23%	Explore
type I pneumocyte	9 studies	34% ± 11%	Explore
mature NK T cell	9 studies	24% ± 10%	Explore
connective tissue cell	9 studies	25% ± 8%	Explore
adipocyte	9 studies	37% ± 10%	Explore
vein endothelial cell	9 studies	32% ± 18%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	29% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	30% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	32% ± 9%	Explore
neuron	8 studies	43% ± 22%	Explore
leukocyte	7 studies	42% ± 17%	Explore
interneuron	7 studies	47% ± 22%	Explore
retinal ganglion cell	7 studies	35% ± 18%	Explore
mucosal invariant T cell	7 studies	22% ± 6%	Explore
myofibroblast cell	7 studies	28% ± 15%	Explore
amacrine cell	7 studies	36% ± 10%	Explore
retinal cone cell	7 studies	35% ± 8%	Explore
retinal rod cell	7 studies	32% ± 11%	Explore
mesothelial cell	7 studies	34% ± 11%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	6 studies	30% ± 14%	Explore
mononuclear phagocyte	6 studies	34% ± 10%	Explore
abnormal cell	6 studies	25% ± 16%	Explore
lymphocyte	6 studies	38% ± 18%	Explore
club cell	6 studies	41% ± 11%	Explore
retina horizontal cell	6 studies	40% ± 9%	Explore
Mueller cell	6 studies	35% ± 12%	Explore
secretory cell	6 studies	21% ± 3%	Explore
T follicular helper cell	6 studies	19% ± 5%	Explore
type II pneumocyte	6 studies	37% ± 10%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	25% ± 12%	Explore
retinal bipolar neuron	5 studies	34% ± 5%	Explore
precursor B cell	5 studies	33% ± 12%	Explore
plasma cell	5 studies	37% ± 11%	Explore
cardiac muscle cell	5 studies	33% ± 4%	Explore
respiratory goblet cell	5 studies	37% ± 16%	Explore
innate lymphoid cell	5 studies	23% ± 9%	Explore
neutrophil	5 studies	23% ± 6%	Explore
goblet cell	5 studies	41% ± 27%	Explore
squamous epithelial cell	4 studies	37% ± 22%	Explore
hematopoietic precursor cell	4 studies	43% ± 16%	Explore
granule cell	4 studies	43% ± 12%	Explore
progenitor cell	4 studies	30% ± 6%	Explore
pro-B cell	4 studies	30% ± 14%	Explore
retinal pigment epithelial cell	4 studies	46% ± 22%	Explore
OFF-bipolar cell	4 studies	35% ± 12%	Explore
ON-bipolar cell	4 studies	36% ± 13%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	22% ± 7%	Explore
hepatocyte	4 studies	52% ± 17%	Explore
alveolar macrophage	4 studies	39% ± 17%	Explore
ionocyte	3 studies	28% ± 11%	Explore
pancreatic A cell	3 studies	31% ± 7%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	21% ± 6%	Explore
plasmablast	3 studies	35% ± 15%	Explore
glomerular endothelial cell	3 studies	22% ± 1%	Explore
GABAergic interneuron	3 studies	35% ± 5%	Explore
glial cell	3 studies	35% ± 6%	Explore
brush cell	3 studies	36% ± 5%	Explore
GABAergic amacrine cell	3 studies	37% ± 8%	Explore
glycinergic amacrine cell	3 studies	36% ± 3%	Explore
rod bipolar cell	3 studies	41% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	34% ± 14%	Explore
muscle cell	3 studies	40% ± 25%	Explore
ependymal cell	3 studies	52% ± 17%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	50% ± 5%	Explore
enteroendocrine cell	3 studies	31% ± 7%	Explore
adventitial cell	3 studies	27% ± 10%	Explore
chondrocyte	3 studies	34% ± 14%	Explore
group 3 innate lymphoid cell	3 studies	29% ± 10%	Explore
Schwann cell	3 studies	36% ± 16%	Explore
transit amplifying cell	3 studies	44% ± 35%	Explore
keratinocyte	3 studies	29% ± 7%	Explore
T-helper 17 cell	3 studies	20% ± 2%	Explore
immature B cell	3 studies	34% ± 12%	Explore
renal alpha-intercalated cell	3 studies	21% ± 7%	Explore
renal principal cell	3 studies	26% ± 8%	Explore
mural cell	3 studies	51% ± 10%	Explore
mucus secreting cell	3 studies	37% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	19 studies	41% ± 21%	Explore
lung	13 studies	30% ± 10%	Explore
peripheral blood	12 studies	27% ± 13%	Explore
eye	9 studies	39% ± 16%	Explore
heart	5 studies	31% ± 6%	Explore
liver	5 studies	37% ± 17%	Explore
intestine	5 studies	23% ± 9%	Explore
bone marrow	4 studies	32% ± 15%	Explore
adipose	4 studies	34% ± 11%	Explore
kidney	4 studies	24% ± 8%	Explore
placenta	3 studies	30% ± 17%	Explore
uterus	3 studies	31% ± 14%	Explore
breast	3 studies	25% ± 5%	Explore
skin	3 studies	24% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	10232.66	459 / 459	100%	52.06	1118 / 1118
esophagus	100%	9494.33	1445 / 1445	100%	43.71	183 / 183
lung	100%	10313.42	578 / 578	100%	37.63	1155 / 1155
ovary	100%	10484.87	180 / 180	100%	34.46	430 / 430
prostate	100%	8901.13	245 / 245	100%	41.12	502 / 502
stomach	100%	7202.20	359 / 359	100%	35.36	286 / 286
brain	100%	11097.16	2640 / 2642	100%	47.53	705 / 705
bladder	100%	10997.71	21 / 21	100%	33.97	503 / 504
uterus	100%	10910.57	170 / 170	100%	37.24	458 / 459
thymus	100%	9523.18	653 / 653	100%	40.93	603 / 605
intestine	100%	10997.84	966 / 966	100%	34.29	525 / 527
pancreas	100%	4461.81	328 / 328	99%	34.30	177 / 178
kidney	100%	6861.27	89 / 89	99%	34.90	888 / 901
liver	100%	3749.23	226 / 226	98%	21.79	397 / 406
adrenal gland	100%	7404.63	258 / 258	97%	31.37	224 / 230
skin	100%	9237.71	1808 / 1809	97%	33.29	458 / 472
adipose	100%	10195.44	1204 / 1204	0%	0	0 / 0
blood vessel	100%	12293.03	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	33.23	29 / 29
spleen	100%	9163.63	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	34.18	45 / 45
ureter	0%	0	0 / 0	100%	13.20	1 / 1
muscle	100%	5988.93	801 / 803	0%	0	0 / 0
peripheral blood	98%	8201.93	911 / 929	0%	0	0 / 0
heart	98%	5949.06	842 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	95%	27.78	76 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006974	Biological process	DNA damage response
GO_0031571	Biological process	mitotic G1 DNA damage checkpoint signaling
GO_0010506	Biological process	regulation of autophagy
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0032435	Biological process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0016239	Biological process	positive regulation of macroautophagy
GO_1904263	Biological process	positive regulation of TORC1 signaling
GO_0006338	Biological process	chromatin remodeling
GO_0016607	Cellular component	nuclear speck
GO_0005654	Cellular component	nucleoplasm
GO_0005681	Cellular component	spliceosomal complex
GO_0005634	Cellular component	nucleus
GO_0000993	Molecular function	RNA polymerase II complex binding
GO_0005515	Molecular function	protein binding
GO_0003682	Molecular function	chromatin binding

IV. Literature review

[source]

Gene name	WAC
Protein name	WW domain containing adaptor with coiled-coil WW domain-containing adapter protein with coiled-coil
Synonyms	KIAA1844
Description	FUNCTION: Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1) . Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription . Regulates the cell-cycle checkpoint activation in response to DNA damage . Positive regulator of amino acid starvation-induced autophagy . Also acts as a negative regulator of basal autophagy . Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation . May negatively regulate the ubiquitin proteasome pathway . .
Accessions	ENST00000424454.5 ENST00000679428.1 [Q9BTA9-2] ENST00000375664.8 [Q9BTA9-2] A0A494C0C1 ENST00000354911.9 [Q9BTA9-1] A0A7P0TBE3 ENST00000679398.1 [Q9BTA9-2] ENST00000679570.1 ENST00000439676.5 [Q9BTA9-3] ENST00000375646.5 E9PMZ7 ENST00000628285.3 ENST00000442148.6 [Q9BTA9-2] ENST00000442148 C9JMU2 J3QT76 ENST00000651885.1 A0A9L9PXQ9 A0A8V8TQV5 ENST00000681112.1 ENST00000420266.6 ENST00000414108.6 ENST00000347934.8 [Q9BTA9-5] A0A0A0MRT2 J3QTA0 ENST00000651598.1 A0A7P0Z479 ENST00000428935.6 A0A8V8TR65 ENST00000680735.1 C9JVK6 A0A7P0T961 A0A0A0MSR1 ENST00000651441.1 A0A0D9SFY7 ENST00000526722.1 A0A494C0S5 ENST00000700325.1 ENST00000495268.3 A0A494C0B7 ENST00000706612.1 ENST00000448193.5 C9JD58 Q9BTA9

WAC report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review