UPF2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	35 studies	28% ± 7%	Explore
endothelial cell	29 studies	27% ± 10%	Explore
natural killer cell	26 studies	21% ± 4%	Explore
macrophage	18 studies	24% ± 8%	Explore
memory B cell	18 studies	26% ± 7%	Explore
naive B cell	17 studies	24% ± 6%	Explore
T cell	16 studies	20% ± 4%	Explore
CD4-positive, alpha-beta T cell	16 studies	19% ± 4%	Explore
fibroblast	15 studies	24% ± 5%	Explore
mast cell	14 studies	21% ± 5%	Explore
ciliated cell	14 studies	27% ± 13%	Explore
CD8-positive, alpha-beta T cell	14 studies	19% ± 4%	Explore
conventional dendritic cell	13 studies	25% ± 9%	Explore
pericyte	12 studies	21% ± 5%	Explore
gamma-delta T cell	12 studies	21% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	20% ± 5%	Explore
smooth muscle cell	11 studies	19% ± 4%	Explore
regulatory T cell	11 studies	20% ± 3%	Explore
microglial cell	10 studies	28% ± 9%	Explore
plasma cell	10 studies	29% ± 8%	Explore
endothelial cell of lymphatic vessel	9 studies	25% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	19% ± 2%	Explore
monocyte	9 studies	26% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	21% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	20% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	20% ± 4%	Explore
oligodendrocyte	8 studies	27% ± 9%	Explore
epithelial cell	8 studies	38% ± 19%	Explore
adipocyte	8 studies	28% ± 7%	Explore
astrocyte	8 studies	30% ± 12%	Explore
plasmacytoid dendritic cell	8 studies	24% ± 8%	Explore
dendritic cell	7 studies	33% ± 16%	Explore
mature NK T cell	7 studies	20% ± 4%	Explore
capillary endothelial cell	7 studies	20% ± 4%	Explore
glutamatergic neuron	7 studies	39% ± 21%	Explore
myeloid cell	7 studies	24% ± 7%	Explore
type I pneumocyte	7 studies	23% ± 5%	Explore
classical monocyte	6 studies	21% ± 7%	Explore
non-classical monocyte	6 studies	26% ± 8%	Explore
basal cell	6 studies	34% ± 16%	Explore
type II pneumocyte	6 studies	23% ± 5%	Explore
oligodendrocyte precursor cell	6 studies	26% ± 10%	Explore
leukocyte	5 studies	26% ± 4%	Explore
myofibroblast cell	5 studies	22% ± 5%	Explore
connective tissue cell	5 studies	20% ± 4%	Explore
neuron	5 studies	35% ± 12%	Explore
endothelial cell of artery	5 studies	17% ± 1%	Explore
endothelial cell of vascular tree	5 studies	24% ± 10%	Explore
innate lymphoid cell	5 studies	21% ± 4%	Explore
lymphocyte	5 studies	29% ± 8%	Explore
GABAergic neuron	5 studies	38% ± 15%	Explore
goblet cell	5 studies	33% ± 17%	Explore
interneuron	5 studies	34% ± 23%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	20% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	22% ± 5%	Explore
mononuclear phagocyte	4 studies	25% ± 10%	Explore
hematopoietic precursor cell	4 studies	31% ± 18%	Explore
abnormal cell	4 studies	27% ± 14%	Explore
immature B cell	4 studies	24% ± 4%	Explore
precursor B cell	4 studies	29% ± 9%	Explore
pro-B cell	4 studies	27% ± 5%	Explore
retina horizontal cell	4 studies	24% ± 8%	Explore
retinal cone cell	4 studies	25% ± 9%	Explore
retinal rod cell	4 studies	21% ± 4%	Explore
vein endothelial cell	4 studies	24% ± 11%	Explore
Mueller cell	4 studies	20% ± 4%	Explore
hepatocyte	4 studies	40% ± 14%	Explore
brush cell	4 studies	26% ± 8%	Explore
club cell	4 studies	25% ± 6%	Explore
mucosal invariant T cell	4 studies	17% ± 1%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	19% ± 2%	Explore
plasmablast	3 studies	38% ± 11%	Explore
progenitor cell	3 studies	22% ± 3%	Explore
retinal bipolar neuron	3 studies	26% ± 7%	Explore
glial cell	3 studies	23% ± 6%	Explore
rod bipolar cell	3 studies	18% ± 1%	Explore
respiratory goblet cell	3 studies	21% ± 4%	Explore
secretory cell	3 studies	24% ± 10%	Explore
enteroendocrine cell	3 studies	23% ± 6%	Explore
alveolar macrophage	3 studies	29% ± 9%	Explore
T follicular helper cell	3 studies	18% ± 1%	Explore
group 3 innate lymphoid cell	3 studies	27% ± 10%	Explore
transit amplifying cell	3 studies	40% ± 28%	Explore
T-helper 17 cell	3 studies	19% ± 0%	Explore
double negative thymocyte	3 studies	27% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	18% ± 0%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	13 studies	29% ± 14%	Explore
lung	11 studies	23% ± 7%	Explore
peripheral blood	9 studies	23% ± 9%	Explore
eye	7 studies	24% ± 10%	Explore
intestine	6 studies	19% ± 6%	Explore
liver	5 studies	32% ± 17%	Explore
kidney	4 studies	17% ± 2%	Explore
adipose	4 studies	26% ± 3%	Explore
heart	3 studies	18% ± 1%	Explore
bone marrow	3 studies	16% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	3613.29	21 / 21	100%	27.42	504 / 504
esophagus	100%	3114.38	1445 / 1445	100%	38.61	183 / 183
ovary	100%	3449.06	180 / 180	100%	27.19	430 / 430
prostate	100%	3141.78	245 / 245	100%	27.96	502 / 502
breast	100%	3205.98	459 / 459	100%	37.23	1116 / 1118
uterus	100%	3551.51	170 / 170	100%	28.16	457 / 459
thymus	100%	3294.51	653 / 653	100%	25.95	602 / 605
lung	100%	2541.79	577 / 578	100%	26.39	1151 / 1155
pancreas	100%	1611.72	327 / 328	99%	23.09	177 / 178
intestine	100%	3681.38	966 / 966	99%	25.78	522 / 527
stomach	100%	2193.23	359 / 359	99%	28.68	282 / 286
brain	100%	2402.00	2640 / 2642	98%	24.55	694 / 705
skin	100%	3451.61	1808 / 1809	94%	22.87	446 / 472
liver	100%	1502.49	226 / 226	94%	15.66	380 / 406
kidney	100%	2012.94	89 / 89	93%	17.58	842 / 901
adrenal gland	100%	1743.42	257 / 258	92%	13.66	211 / 230
adipose	100%	3201.22	1204 / 1204	0%	0	0 / 0
blood vessel	100%	3549.32	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	29.73	29 / 29
muscle	100%	3305.71	803 / 803	0%	0	0 / 0
spleen	100%	3268.69	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	27.71	45 / 45
ureter	0%	0	0 / 0	100%	9.35	1 / 1
heart	97%	1634.08	837 / 861	0%	0	0 / 0
peripheral blood	95%	2504.90	880 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	93%	19.65	74 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006406	Biological process	mRNA export from nucleus
GO_0001889	Biological process	liver development
GO_0031100	Biological process	animal organ regeneration
GO_0000184	Biological process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO_0035145	Cellular component	exon-exon junction complex
GO_0005829	Cellular component	cytosol
GO_0036464	Cellular component	cytoplasmic ribonucleoprotein granule
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0042162	Molecular function	telomeric DNA binding
GO_0005515	Molecular function	protein binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	UPF2
Protein name	Alternative protein UPF2 UPF2 protein Regulator of nonsense transcripts 2 (Up-frameshift suppressor 2 homolog) (hUpf2)
Synonyms	KIAA1408 RENT2
Description	FUNCTION: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA. .
Accessions	ENST00000397053.6 Q9HAU5 ENST00000356352.6 L0R8K7 Q5BKV2 ENST00000357604.10

UPF2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review