Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 58 studies | 70% ± 17% | |
| fibroblast | 45 studies | 52% ± 16% | |
| B cell | 40 studies | 39% ± 12% | |
| pericyte | 40 studies | 50% ± 20% | |
| plasmacytoid dendritic cell | 29 studies | 82% ± 14% | |
| endothelial cell of lymphatic vessel | 28 studies | 59% ± 15% | |
| smooth muscle cell | 28 studies | 41% ± 18% | |
| macrophage | 28 studies | 34% ± 19% | |
| astrocyte | 21 studies | 68% ± 19% | |
| memory B cell | 20 studies | 37% ± 8% | |
| naive B cell | 19 studies | 32% ± 8% | |
| microglial cell | 19 studies | 52% ± 20% | |
| capillary endothelial cell | 17 studies | 64% ± 16% | |
| endothelial cell of artery | 16 studies | 67% ± 16% | |
| oligodendrocyte precursor cell | 16 studies | 78% ± 15% | |
| vein endothelial cell | 16 studies | 67% ± 18% | |
| endothelial cell of vascular tree | 16 studies | 66% ± 19% | |
| oligodendrocyte | 15 studies | 72% ± 13% | |
| myofibroblast cell | 15 studies | 43% ± 16% | |
| connective tissue cell | 14 studies | 43% ± 18% | |
| plasma cell | 13 studies | 34% ± 14% | |
| basal cell | 12 studies | 36% ± 17% | |
| glutamatergic neuron | 12 studies | 79% ± 19% | |
| GABAergic neuron | 11 studies | 73% ± 29% | |
| conventional dendritic cell | 10 studies | 23% ± 6% | |
| neuron | 10 studies | 62% ± 17% | |
| myeloid cell | 9 studies | 32% ± 14% | |
| dendritic cell | 9 studies | 37% ± 13% | |
| plasmablast | 7 studies | 37% ± 13% | |
| mesothelial cell | 7 studies | 37% ± 11% | |
| amacrine cell | 7 studies | 46% ± 26% | |
| epithelial cell | 7 studies | 34% ± 11% | |
| interneuron | 7 studies | 86% ± 11% | |
| precursor B cell | 7 studies | 50% ± 12% | |
| monocyte | 7 studies | 26% ± 7% | |
| glial cell | 6 studies | 49% ± 22% | |
| retinal cone cell | 6 studies | 35% ± 16% | |
| adipocyte | 6 studies | 36% ± 9% | |
| Mueller cell | 6 studies | 80% ± 12% | |
| progenitor cell | 5 studies | 54% ± 29% | |
| abnormal cell | 5 studies | 48% ± 14% | |
| retinal bipolar neuron | 5 studies | 64% ± 12% | |
| pro-B cell | 5 studies | 67% ± 11% | |
| immature B cell | 5 studies | 40% ± 7% | |
| retinal rod cell | 5 studies | 35% ± 16% | |
| adventitial cell | 5 studies | 41% ± 15% | |
| mononuclear phagocyte | 5 studies | 29% ± 9% | |
| club cell | 4 studies | 24% ± 11% | |
| ionocyte | 4 studies | 26% ± 9% | |
| endothelial cell of sinusoid | 4 studies | 52% ± 20% | |
| glomerular endothelial cell | 4 studies | 54% ± 5% | |
| granule cell | 4 studies | 81% ± 10% | |
| OFF-bipolar cell | 4 studies | 64% ± 27% | |
| glycinergic amacrine cell | 4 studies | 80% ± 22% | |
| hematopoietic stem cell | 4 studies | 18% ± 1% | |
| ciliated cell | 4 studies | 26% ± 4% | |
| Schwann cell | 4 studies | 32% ± 4% | |
| chondrocyte | 4 studies | 50% ± 9% | |
| muscle cell | 4 studies | 28% ± 5% | |
| hepatic stellate cell | 3 studies | 43% ± 19% | |
| T cell | 3 studies | 24% ± 4% | |
| hematopoietic precursor cell | 3 studies | 34% ± 18% | |
| differentiation-committed oligodendrocyte precursor | 3 studies | 72% ± 6% | |
| interstitial cell of Cajal | 3 studies | 54% ± 5% | |
| neural crest cell | 3 studies | 64% ± 11% | |
| GABAergic interneuron | 3 studies | 74% ± 32% | |
| classical monocyte | 3 studies | 18% ± 2% | |
| endocardial cell | 3 studies | 52% ± 12% | |
| lymphocyte | 3 studies | 40% ± 17% | |
| ON-bipolar cell | 3 studies | 64% ± 11% | |
| rod bipolar cell | 3 studies | 78% ± 12% | |
| mast cell | 3 studies | 30% ± 12% | |
| germinal center B cell | 3 studies | 34% ± 3% | |
| ependymal cell | 3 studies | 70% ± 11% | |
| leukocyte | 3 studies | 28% ± 12% | |
| respiratory goblet cell | 3 studies | 42% ± 17% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 19 studies | 68% ± 21% | |
| lung | 11 studies | 27% ± 11% | |
| eye | 10 studies | 39% ± 14% | |
| heart | 6 studies | 36% ± 9% | |
| skin | 6 studies | 27% ± 10% | |
| intestine | 5 studies | 37% ± 13% | |
| breast | 4 studies | 23% ± 6% | |
| adipose | 4 studies | 37% ± 15% | |
| kidney | 3 studies | 21% ± 4% | |
| uterus | 3 studies | 33% ± 8% | |
| liver | 3 studies | 21% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 7357.96 | 2639 / 2642 | 100% | 35.28 | 704 / 705 |
| breast | 100% | 11198.30 | 459 / 459 | 92% | 10.76 | 1027 / 1118 |
| thymus | 100% | 7500.79 | 653 / 653 | 91% | 8.57 | 551 / 605 |
| adrenal gland | 100% | 6130.21 | 257 / 258 | 87% | 15.84 | 199 / 230 |
| lung | 100% | 10239.46 | 578 / 578 | 85% | 8.38 | 987 / 1155 |
| esophagus | 98% | 3760.00 | 1412 / 1445 | 85% | 9.49 | 156 / 183 |
| prostate | 100% | 3880.72 | 244 / 245 | 77% | 4.73 | 388 / 502 |
| uterus | 100% | 8700.66 | 170 / 170 | 72% | 7.29 | 329 / 459 |
| ovary | 100% | 7355.09 | 180 / 180 | 66% | 4.08 | 285 / 430 |
| bladder | 100% | 5118.86 | 21 / 21 | 48% | 3.81 | 243 / 504 |
| intestine | 97% | 5463.61 | 941 / 966 | 48% | 3.45 | 255 / 527 |
| kidney | 75% | 1817.02 | 67 / 89 | 62% | 10.02 | 562 / 901 |
| stomach | 74% | 2147.21 | 266 / 359 | 63% | 4.97 | 181 / 286 |
| skin | 100% | 5363.77 | 1806 / 1809 | 37% | 4.35 | 175 / 472 |
| pancreas | 22% | 365.25 | 72 / 328 | 87% | 8.24 | 155 / 178 |
| adipose | 100% | 12718.85 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 100% | 5246.77 | 241 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 6336.97 | 1332 / 1335 | 0% | 0 | 0 / 0 |
| heart | 100% | 4566.92 | 859 / 861 | 0% | 0 | 0 / 0 |
| muscle | 98% | 2841.46 | 785 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 97% | 18.72 | 28 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 82% | 7.57 | 37 / 45 |
| liver | 9% | 145.32 | 20 / 226 | 19% | 0.94 | 78 / 406 |
| peripheral blood | 19% | 1623.50 | 178 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 3% | 0.09 | 2 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0065004 | Biological process | protein-DNA complex assembly |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0030154 | Biological process | cell differentiation |
| GO_0045666 | Biological process | positive regulation of neuron differentiation |
| GO_0007399 | Biological process | nervous system development |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0070369 | Cellular component | beta-catenin-TCF7L2 complex |
| GO_1990907 | Cellular component | beta-catenin-TCF complex |
| GO_0000785 | Cellular component | chromatin |
| GO_0005667 | Cellular component | transcription regulator complex |
| GO_0005634 | Cellular component | nucleus |
| GO_0003677 | Molecular function | DNA binding |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO_0001093 | Molecular function | TFIIB-class transcription factor binding |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0008013 | Molecular function | beta-catenin binding |
| GO_0003700 | Molecular function | DNA-binding transcription factor activity |
| GO_0046982 | Molecular function | protein heterodimerization activity |
| GO_0070888 | Molecular function | E-box binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | TCF4 |
| Protein name | Transcription factor 4, isoform E Transcription factor 4, isoform D Transcription factor 4 Transcription factor 4, isoform M Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2) Transcription factor 4, isoform R Transcription factor 4, isoform C Transcription factor 4, isoform L |
| Synonyms | hCG_1811800 SEF2 ITF2 BHLHB19 |
| Description | FUNCTION: Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. . |
| Accessions | A0A1B0GVR6 ENST00000630319.2 ENST00000627685.2 A0A0D9SG44 ENST00000457482.7 [P15884-2] ENST00000566286.5 [P15884-12] A0A1B0GVB8 ENST00000544241.6 [P15884-11] H3BTP3 ENST00000637169.2 A0A0D9SGH7 A0A0D9SGE5 A0A1B0GXH5 ENST00000563824.5 ENST00000566777.5 ENST00000569357.4 ENST00000627320.2 ENST00000564403.6 G0LNT7 ENST00000626595.2 H3BML7 ENST00000674764.1 A0A1B0GW91 A0A1B0GV10 ENST00000629343.2 ENST00000637923.2 ENST00000398339.5 ENST00000565393.2 ENST00000568147.5 ENST00000537856.7 [P15884-9] A0A0D9SGE4 H3BT24 ENST00000636822.2 ENST00000564343.5 H3BME8 ENST00000543082.5 [P15884-10] ENST00000626584.2 [P15884-16] ENST00000630828.2 ENST00000563888.6 H3BPJ7 ENST00000561831.7 [P15884-8] ENST00000616053.4 [P15884-15] ENST00000636400.2 [P15884-13] ENST00000570177.6 [P15884-9] A0A0E3D6N2 ENST00000566514.5 H3BRF7 A0A0D9SEZ3 ENST00000636751.2 ENST00000627784.2 G0LNT2 G0LNT8 ENST00000628078.2 ENST00000568673.5 [P15884-13] ENST00000561992.5 [P15884-9] ENST00000629387.2 [P15884-3] ENST00000562847.5 H3BUQ3 A0A075B723 ENST00000565124.4 ENST00000564999.5 [P15884-1] ENST00000626425.2 ENST00000568186.5 A0A0D9SFU5 A0A0D9SG78 A0A0D9SEX8 ENST00000628689.2 H3BTZ0 ENST00000570287.6 [P15884-6] ENST00000565018.6 [P15884-15] ENST00000643689.1 A0A1B0GWD5 ENST00000638154.3 G0LNT3 ENST00000570146.3 G0LNT4 ENST00000568740.5 A0A6Q8PGE3 G0LNT6 H3BNZ2 ENST00000562543.5 A0A0D9SEK1 A0A0D9SFX5 H3BPG3 ENST00000568169.5 ENST00000630712.2 A0A1B0GUT3 A0A1B0GTP2 H3BTC3 P15884 ENST00000630720.3 ENST00000569012.5 ENST00000540999.5 [P15884-14] G0LNT1 ENST00000637115.2 ENST00000356073.8 [P15884-1] A0A0D9SG61 A0A0D9SGJ4 ENST00000675707.1 A0A0D9SG55 A0A0D9SF18 A0A0D9SF97 ENST00000590810.5 ENST00000562030.3 ENST00000562638.5 ENST00000635822.2 ENST00000354452.8 [P15884-3] H3BTM9 ENST00000567880.5 [P15884-5] K7ESI6 G0LNT5 H3BT95 H3BMC8 H3BP59 ENST00000626631.1 A0A0D9SFZ1 ENST00000630268.2 ENST00000628636.2 ENST00000625925.2 H3BNI2 ENST00000566279.5 [P15884-4] ENST00000630224.2 ENST00000565908.6 ENST00000537578.5 [P15884-13] ENST00000562607.5 E9PH57 A0A0D9SGE7 ENST00000564228.5 [P15884-7] |