TCF4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0065004Biological processprotein-DNA complex assembly
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0030154Biological processcell differentiation
GO_0045666Biological processpositive regulation of neuron differentiation
GO_0007399Biological processnervous system development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0070369Cellular componentbeta-catenin-TCF7L2 complex
GO_1990907Cellular componentbeta-catenin-TCF complex
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0001093Molecular functionTFIIB-class transcription factor binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0042802Molecular functionidentical protein binding
GO_0008013Molecular functionbeta-catenin binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0046982Molecular functionprotein heterodimerization activity
GO_0070888Molecular functionE-box binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTCF4
Protein nameTranscription factor 4, isoform E
Transcription factor 4, isoform D
Transcription factor 4
Transcription factor 4, isoform M
Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2)
Transcription factor 4, isoform R
Transcription factor 4, isoform C
Transcription factor 4, isoform L
SynonymshCG_1811800
SEF2
ITF2
BHLHB19
DescriptionFUNCTION: Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. .

AccessionsA0A1B0GVR6
ENST00000630319.2
ENST00000627685.2
A0A0D9SG44
ENST00000457482.7 [P15884-2]
ENST00000566286.5 [P15884-12]
A0A1B0GVB8
ENST00000544241.6 [P15884-11]
H3BTP3
ENST00000637169.2
A0A0D9SGH7
A0A0D9SGE5
A0A1B0GXH5
ENST00000563824.5
ENST00000566777.5
ENST00000569357.4
ENST00000627320.2
ENST00000564403.6
G0LNT7
ENST00000626595.2
H3BML7
ENST00000674764.1
A0A1B0GW91
A0A1B0GV10
ENST00000629343.2
ENST00000637923.2
ENST00000398339.5
ENST00000565393.2
ENST00000568147.5
ENST00000537856.7 [P15884-9]
A0A0D9SGE4
H3BT24
ENST00000636822.2
ENST00000564343.5
H3BME8
ENST00000543082.5 [P15884-10]
ENST00000626584.2 [P15884-16]
ENST00000630828.2
ENST00000563888.6
H3BPJ7
ENST00000561831.7 [P15884-8]
ENST00000616053.4 [P15884-15]
ENST00000636400.2 [P15884-13]
ENST00000570177.6 [P15884-9]
A0A0E3D6N2
ENST00000566514.5
H3BRF7
A0A0D9SEZ3
ENST00000636751.2
ENST00000627784.2
G0LNT2
G0LNT8
ENST00000628078.2
ENST00000568673.5 [P15884-13]
ENST00000561992.5 [P15884-9]
ENST00000629387.2 [P15884-3]
ENST00000562847.5
H3BUQ3
A0A075B723
ENST00000565124.4
ENST00000564999.5 [P15884-1]
ENST00000626425.2
ENST00000568186.5
A0A0D9SFU5
A0A0D9SG78
A0A0D9SEX8
ENST00000628689.2
H3BTZ0
ENST00000570287.6 [P15884-6]
ENST00000565018.6 [P15884-15]
ENST00000643689.1
A0A1B0GWD5
ENST00000638154.3
G0LNT3
ENST00000570146.3
G0LNT4
ENST00000568740.5
A0A6Q8PGE3
G0LNT6
H3BNZ2
ENST00000562543.5
A0A0D9SEK1
A0A0D9SFX5
H3BPG3
ENST00000568169.5
ENST00000630712.2
A0A1B0GUT3
A0A1B0GTP2
H3BTC3
P15884
ENST00000630720.3
ENST00000569012.5
ENST00000540999.5 [P15884-14]
G0LNT1
ENST00000637115.2
ENST00000356073.8 [P15884-1]
A0A0D9SG61
A0A0D9SGJ4
ENST00000675707.1
A0A0D9SG55
A0A0D9SF18
A0A0D9SF97
ENST00000590810.5
ENST00000562030.3
ENST00000562638.5
ENST00000635822.2
ENST00000354452.8 [P15884-3]
H3BTM9
ENST00000567880.5 [P15884-5]
K7ESI6
G0LNT5
H3BT95
H3BMC8
H3BP59
ENST00000626631.1
A0A0D9SFZ1
ENST00000630268.2
ENST00000628636.2
ENST00000625925.2
H3BNI2
ENST00000566279.5 [P15884-4]
ENST00000630224.2
ENST00000565908.6
ENST00000537578.5 [P15884-13]
ENST00000562607.5
E9PH57
A0A0D9SGE7
ENST00000564228.5 [P15884-7]