TAP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019885Biological processantigen processing and presentation of endogenous peptide antigen via MHC class I
GO_0055085Biological processtransmembrane transport
GO_0002250Biological processadaptive immune response
GO_0015833Biological processpeptide transport
GO_0015031Biological processprotein transport
GO_0046967Biological processcytosol to endoplasmic reticulum transport
GO_0006952Biological processdefense response
GO_0034451Cellular componentcentriolar satellite
GO_0042825Cellular componentTAP complex
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0033116Cellular componentendoplasmic reticulum-Golgi intermediate compartment membrane
GO_0042824Cellular componentMHC class I peptide loading complex
GO_0005783Cellular componentendoplasmic reticulum
GO_0030670Cellular componentphagocytic vesicle membrane
GO_0042803Molecular functionprotein homodimerization activity
GO_0015433Molecular functionABC-type peptide antigen transporter activity
GO_0043531Molecular functionADP binding
GO_0023029Molecular functionMHC class Ib protein binding
GO_0042288Molecular functionMHC class I protein binding
GO_0046872Molecular functionmetal ion binding
GO_1904680Molecular functionpeptide transmembrane transporter activity
GO_0005524Molecular functionATP binding
GO_0046979Molecular functionTAP2 binding
GO_0005515Molecular functionprotein binding
GO_0046978Molecular functionTAP1 binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0042605Molecular functionpeptide antigen binding

IV. Literature review

[source]
Gene nameTAP1
Protein nameAlternative protein TAP1
Transporter 1
TAP1
Antigen peptide transporter 1 (APT1) (EC 7.4.2.14) (ATP-binding cassette sub-family B member 2) (Peptide supply factor 1) (Peptide transporter PSF1) (PSF-1) (Peptide transporter TAP1) (Peptide transporter involved in antigen processing 1) (Really interesting new gene 4 protein) (RING4)
Transporter 1 ATP-binding cassette sub-family B isoform 2
ABC-type antigen peptide transporter (EC 7.4.2.14)
Transporter 1, ATP binding cassette subfamily B member
TAP1 protein
SynonymsY3
PSF1
ABCB2
RING4
DescriptionFUNCTION: ABC transporter associated with antigen processing. In complex with TAP2 mediates unidirectional translocation of peptide antigens from cytosol to endoplasmic reticulum (ER) for loading onto MHC class I (MHCI) molecules . Uses the chemical energy of ATP to export peptides against the concentration gradient . During the transport cycle alternates between 'inward-facing' state with peptide binding site facing the cytosol to 'outward-facing' state with peptide binding site facing the ER lumen. Peptide antigen binding to ATP-loaded TAP1-TAP2 induces a switch to hydrolysis-competent 'outward-facing' conformation ready for peptide loading onto nascent MHCI molecules. Subsequently ATP hydrolysis resets the transporter to the 'inward facing' state for a new cycle . Typically transports intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via IFNG-induced immunoproteasome. Binds peptides with free N- and C-termini, the first three and the C-terminal residues being critical. Preferentially selects peptides having a highly hydrophobic residue at position 3 and hydrophobic or charged residues at the C-terminal anchor. Proline at position 2 has the most destabilizing effect . As a component of the peptide loading complex (PLC), acts as a molecular scaffold essential for peptide-MHCI assembly and antigen presentation . .

AccessionsA0A8V8TN61
Q6QWC1
X5CKB3
A0A2R8Y4Y0
A0A0S2Z4R8
ENST00000418205.2 [Q03518-2]
Q12848
ENST00000414467.2 [Q03518-2]
Q69DM1
Q03518
ENST00000643049.2
ENST00000383235.4 [Q03518-2]
ENST00000354258.5 [Q03518-1]
ENST00000698420.1
Q12847
ENST00000698421.1
A0A8V8TLN3
ENST00000698422.1
Q53WZ1
L8E792
ENST00000424897.2 [Q03518-2]
ENST00000428324.2
Q16148
ENST00000439781.2 [Q03518-2]
ENST00000698424.1
ENST00000698423.1
A0A8V8TM76
A0A8V8TNH0
A0A0S2Z5A6
A0A8V8TLQ7
Q13013
Q8TD77
ENST00000440894.2 [Q03518-2]
A0A140T9T7
Q6QWC0