SREK1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	35 studies	28% ± 10%	Explore
fibroblast	28 studies	24% ± 8%	Explore
smooth muscle cell	20 studies	22% ± 4%	Explore
natural killer cell	18 studies	21% ± 6%	Explore
pericyte	18 studies	23% ± 7%	Explore
B cell	17 studies	24% ± 10%	Explore
ciliated cell	16 studies	32% ± 13%	Explore
macrophage	15 studies	24% ± 8%	Explore
astrocyte	14 studies	30% ± 14%	Explore
endothelial cell of lymphatic vessel	13 studies	25% ± 8%	Explore
epithelial cell	13 studies	34% ± 21%	Explore
oligodendrocyte precursor cell	12 studies	31% ± 14%	Explore
T cell	11 studies	21% ± 5%	Explore
CD8-positive, alpha-beta T cell	11 studies	22% ± 7%	Explore
memory B cell	11 studies	18% ± 2%	Explore
plasmacytoid dendritic cell	11 studies	23% ± 7%	Explore
basal cell	11 studies	28% ± 14%	Explore
CD4-positive, alpha-beta T cell	10 studies	23% ± 9%	Explore
connective tissue cell	10 studies	25% ± 8%	Explore
type I pneumocyte	9 studies	24% ± 5%	Explore
myofibroblast cell	9 studies	29% ± 7%	Explore
monocyte	9 studies	19% ± 4%	Explore
vein endothelial cell	9 studies	23% ± 11%	Explore
regulatory T cell	9 studies	20% ± 4%	Explore
oligodendrocyte	9 studies	27% ± 9%	Explore
classical monocyte	8 studies	29% ± 13%	Explore
naive B cell	8 studies	22% ± 3%	Explore
GABAergic neuron	8 studies	36% ± 22%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	23% ± 7%	Explore
endothelial cell of artery	8 studies	19% ± 2%	Explore
glutamatergic neuron	8 studies	41% ± 26%	Explore
endothelial cell of vascular tree	8 studies	22% ± 10%	Explore
adipocyte	8 studies	24% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	7 studies	24% ± 7%	Explore
capillary endothelial cell	7 studies	23% ± 2%	Explore
progenitor cell	7 studies	26% ± 7%	Explore
mesothelial cell	7 studies	25% ± 10%	Explore
type II pneumocyte	7 studies	26% ± 8%	Explore
hematopoietic precursor cell	6 studies	27% ± 16%	Explore
neuron	6 studies	34% ± 13%	Explore
microglial cell	6 studies	24% ± 5%	Explore
lymphocyte	6 studies	23% ± 9%	Explore
precursor B cell	6 studies	31% ± 11%	Explore
mast cell	6 studies	31% ± 20%	Explore
club cell	6 studies	25% ± 9%	Explore
Mueller cell	6 studies	27% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	21% ± 4%	Explore
secretory cell	5 studies	23% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	5 studies	23% ± 8%	Explore
non-classical monocyte	5 studies	30% ± 15%	Explore
mature NK T cell	5 studies	20% ± 5%	Explore
amacrine cell	5 studies	29% ± 5%	Explore
interneuron	5 studies	42% ± 23%	Explore
pro-B cell	5 studies	33% ± 5%	Explore
myeloid cell	5 studies	27% ± 7%	Explore
dendritic cell	5 studies	37% ± 22%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	20% ± 3%	Explore
leukocyte	4 studies	22% ± 5%	Explore
conventional dendritic cell	4 studies	34% ± 18%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	26% ± 11%	Explore
abnormal cell	4 studies	35% ± 9%	Explore
glial cell	4 studies	27% ± 11%	Explore
mucosal invariant T cell	4 studies	17% ± 1%	Explore
immature B cell	4 studies	23% ± 5%	Explore
retina horizontal cell	4 studies	27% ± 6%	Explore
retinal cone cell	4 studies	27% ± 4%	Explore
retinal rod cell	4 studies	18% ± 2%	Explore
respiratory goblet cell	4 studies	27% ± 8%	Explore
hepatocyte	4 studies	42% ± 16%	Explore
goblet cell	4 studies	41% ± 24%	Explore
gamma-delta T cell	4 studies	32% ± 20%	Explore
type B pancreatic cell	3 studies	39% ± 17%	Explore
exhausted T cell	3 studies	26% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	26% ± 11%	Explore
plasmablast	3 studies	47% ± 17%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	22% ± 5%	Explore
neural crest cell	3 studies	30% ± 3%	Explore
GABAergic interneuron	3 studies	22% ± 4%	Explore
retinal ganglion cell	3 studies	31% ± 7%	Explore
kidney loop of Henle epithelial cell	3 studies	17% ± 1%	Explore
plasma cell	3 studies	28% ± 16%	Explore
erythroblast	3 studies	31% ± 15%	Explore
T follicular helper cell	3 studies	18% ± 3%	Explore
germinal center B cell	3 studies	18% ± 2%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	25% ± 11%	Explore
innate lymphoid cell	3 studies	18% ± 2%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	19% ± 1%	Explore
muscle cell	3 studies	32% ± 14%	Explore
pancreatic A cell	3 studies	39% ± 13%	Explore
ependymal cell	3 studies	35% ± 14%	Explore
enteroendocrine cell	3 studies	29% ± 11%	Explore
group 3 innate lymphoid cell	3 studies	33% ± 9%	Explore
transit amplifying cell	3 studies	36% ± 24%	Explore
mucus secreting cell	3 studies	20% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	12 studies	34% ± 19%	Explore
lung	11 studies	23% ± 6%	Explore
peripheral blood	8 studies	28% ± 14%	Explore
eye	7 studies	24% ± 11%	Explore
intestine	5 studies	26% ± 9%	Explore
kidney	4 studies	20% ± 4%	Explore
adipose	4 studies	22% ± 4%	Explore
pancreas	3 studies	36% ± 16%	Explore
heart	3 studies	18% ± 2%	Explore
liver	3 studies	41% ± 12%	Explore
bone marrow	3 studies	18% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	5332.42	1444 / 1445	100%	15.49	183 / 183
prostate	100%	6561.45	245 / 245	100%	13.28	501 / 502
lung	100%	5894.25	577 / 578	100%	11.65	1153 / 1155
thymus	100%	10050.32	653 / 653	100%	14.87	602 / 605
breast	100%	7398.11	459 / 459	99%	16.19	1112 / 1118
uterus	100%	8703.15	170 / 170	99%	13.57	456 / 459
brain	99%	2977.19	2620 / 2642	100%	13.65	705 / 705
pancreas	100%	4749.05	328 / 328	99%	11.24	176 / 178
adrenal gland	100%	5925.20	258 / 258	99%	10.50	227 / 230
stomach	100%	5005.84	359 / 359	98%	10.71	279 / 286
bladder	100%	5731.81	21 / 21	97%	10.46	491 / 504
kidney	100%	4603.93	89 / 89	97%	12.20	873 / 901
ovary	100%	6755.68	180 / 180	97%	7.86	416 / 430
intestine	100%	6471.71	966 / 966	96%	10.38	506 / 527
skin	100%	6710.41	1809 / 1809	89%	10.79	421 / 472
liver	100%	3902.32	226 / 226	83%	5.88	337 / 406
blood vessel	100%	5268.55	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	10.20	29 / 29
spleen	100%	6611.09	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	12.17	45 / 45
ureter	0%	0	0 / 0	100%	4.34	1 / 1
adipose	100%	6355.98	1203 / 1204	0%	0	0 / 0
muscle	100%	3461.81	802 / 803	0%	0	0 / 0
heart	98%	3346.10	843 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	55%	5.49	44 / 80
peripheral blood	47%	2170.63	435 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	SREK1
Protein name	Splicing regulatory glutamic acid and lysine rich protein 1 Splicing regulatory glutamine/lysine-rich protein 1 (Serine/arginine-rich-splicing regulatory protein 86) (SRrp86) (Splicing factor, arginine/serine-rich 12) (Splicing regulatory protein 508) (SRrp508)
Synonyms	SRRP86 SFRS12
Description	FUNCTION: Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity). .
Accessions	ENST00000521691.5 ENST00000522912.5 ENST00000612404.4 Q8WXA9 E5RK30 A0A087WY03 ENST00000520953.5 H0YC47 ENST00000523655.1 E5RFV3 ENST00000380918.7 [Q8WXA9-1] E5RJ76 ENST00000334121.11 [Q8WXA9-2]

GO_0008380	Biological process	RNA splicing
GO_0006397	Biological process	mRNA processing
GO_0016607	Cellular component	nuclear speck
GO_0005654	Cellular component	nucleoplasm
GO_0005681	Cellular component	spliceosomal complex
GO_0005515	Molecular function	protein binding
GO_0003723	Molecular function	RNA binding

SREK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review