SPTAN1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	47 studies	36% ± 15%	Explore
fibroblast	28 studies	25% ± 9%	Explore
regulatory T cell	20 studies	28% ± 8%	Explore
natural killer cell	19 studies	23% ± 7%	Explore
CD4-positive, alpha-beta T cell	19 studies	25% ± 6%	Explore
pericyte	18 studies	26% ± 13%	Explore
T cell	17 studies	26% ± 11%	Explore
endothelial cell of lymphatic vessel	17 studies	34% ± 12%	Explore
astrocyte	17 studies	34% ± 15%	Explore
smooth muscle cell	16 studies	21% ± 6%	Explore
ciliated cell	16 studies	35% ± 11%	Explore
B cell	15 studies	20% ± 4%	Explore
CD8-positive, alpha-beta T cell	15 studies	27% ± 6%	Explore
capillary endothelial cell	15 studies	29% ± 11%	Explore
epithelial cell	14 studies	33% ± 18%	Explore
endothelial cell of artery	13 studies	35% ± 16%	Explore
type I pneumocyte	12 studies	36% ± 11%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	25% ± 8%	Explore
glutamatergic neuron	12 studies	57% ± 22%	Explore
vein endothelial cell	12 studies	32% ± 16%	Explore
oligodendrocyte precursor cell	12 studies	34% ± 12%	Explore
mucosal invariant T cell	12 studies	27% ± 10%	Explore
gamma-delta T cell	12 studies	28% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	26% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	26% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	23% ± 5%	Explore
GABAergic neuron	10 studies	55% ± 21%	Explore
memory B cell	10 studies	20% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	24% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	25% ± 6%	Explore
neuron	9 studies	46% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	23% ± 4%	Explore
mature NK T cell	8 studies	25% ± 3%	Explore
mesothelial cell	8 studies	37% ± 15%	Explore
amacrine cell	8 studies	41% ± 12%	Explore
retinal cone cell	8 studies	42% ± 12%	Explore
retinal rod cell	8 studies	23% ± 6%	Explore
myofibroblast cell	8 studies	23% ± 6%	Explore
endothelial cell of vascular tree	8 studies	28% ± 12%	Explore
basal cell	7 studies	34% ± 15%	Explore
naive B cell	7 studies	21% ± 3%	Explore
retinal ganglion cell	7 studies	77% ± 21%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	22% ± 4%	Explore
connective tissue cell	6 studies	21% ± 3%	Explore
abnormal cell	6 studies	27% ± 11%	Explore
interneuron	6 studies	60% ± 15%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	30% ± 8%	Explore
respiratory goblet cell	5 studies	21% ± 5%	Explore
secretory cell	5 studies	31% ± 12%	Explore
retinal bipolar neuron	5 studies	46% ± 14%	Explore
macrophage	5 studies	30% ± 14%	Explore
OFF-bipolar cell	5 studies	47% ± 27%	Explore
myeloid cell	5 studies	20% ± 4%	Explore
retina horizontal cell	5 studies	33% ± 8%	Explore
cardiac muscle cell	5 studies	23% ± 2%	Explore
lymphocyte	5 studies	30% ± 6%	Explore
Mueller cell	5 studies	28% ± 9%	Explore
T follicular helper cell	5 studies	28% ± 4%	Explore
squamous epithelial cell	4 studies	45% ± 18%	Explore
exhausted T cell	4 studies	33% ± 10%	Explore
podocyte	4 studies	38% ± 8%	Explore
granule cell	4 studies	45% ± 4%	Explore
microglial cell	4 studies	28% ± 14%	Explore
retinal pigment epithelial cell	4 studies	33% ± 12%	Explore
ON-bipolar cell	4 studies	57% ± 26%	Explore
innate lymphoid cell	4 studies	21% ± 5%	Explore
enteroendocrine cell	4 studies	24% ± 6%	Explore
mast cell	3 studies	19% ± 1%	Explore
ionocyte	3 studies	29% ± 1%	Explore
leukocyte	3 studies	22% ± 4%	Explore
conventional dendritic cell	3 studies	22% ± 7%	Explore
glomerular endothelial cell	3 studies	24% ± 5%	Explore
GABAergic interneuron	3 studies	57% ± 12%	Explore
glial cell	3 studies	31% ± 8%	Explore
progenitor cell	3 studies	26% ± 7%	Explore
precursor B cell	3 studies	22% ± 4%	Explore
pro-B cell	3 studies	28% ± 6%	Explore
club cell	3 studies	25% ± 4%	Explore
type II pneumocyte	3 studies	18% ± 1%	Explore
rod bipolar cell	3 studies	58% ± 7%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	33% ± 6%	Explore
CD4-positive helper T cell	3 studies	29% ± 9%	Explore
muscle cell	3 studies	29% ± 9%	Explore
dendritic cell	3 studies	23% ± 5%	Explore
ependymal cell	3 studies	49% ± 17%	Explore
goblet cell	3 studies	36% ± 19%	Explore
adventitial cell	3 studies	24% ± 2%	Explore
group 3 innate lymphoid cell	3 studies	31% ± 12%	Explore
melanocyte	3 studies	30% ± 11%	Explore
brush cell	3 studies	18% ± 3%	Explore
T-helper 1 cell	3 studies	21% ± 7%	Explore
adipocyte	3 studies	24% ± 10%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	26% ± 6%	Explore
double negative thymocyte	3 studies	28% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	20% ± 7%	Explore
oligodendrocyte	3 studies	27% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	17 studies	41% ± 20%	Explore
lung	12 studies	25% ± 7%	Explore
eye	11 studies	32% ± 12%	Explore
peripheral blood	10 studies	23% ± 5%	Explore
heart	5 studies	20% ± 4%	Explore
kidney	4 studies	24% ± 1%	Explore
intestine	4 studies	21% ± 4%	Explore
adipose	4 studies	27% ± 3%	Explore
bone marrow	3 studies	23% ± 3%	Explore
uterus	3 studies	29% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	44750.82	2642 / 2642	100%	181.07	705 / 705
esophagus	100%	21052.45	1445 / 1445	100%	83.51	183 / 183
intestine	100%	20933.50	966 / 966	100%	76.52	526 / 527
skin	100%	25663.52	1809 / 1809	100%	86.65	471 / 472
breast	100%	19678.38	459 / 459	100%	82.48	1113 / 1118
thymus	100%	21750.90	653 / 653	100%	98.33	602 / 605
prostate	100%	18643.44	245 / 245	99%	51.17	499 / 502
ovary	100%	22305.37	180 / 180	99%	61.96	427 / 430
uterus	100%	27952.26	170 / 170	99%	62.35	454 / 459
kidney	100%	17647.97	89 / 89	98%	63.14	887 / 901
lung	100%	23731.98	577 / 578	98%	53.86	1130 / 1155
stomach	97%	12724.30	349 / 359	100%	77.24	285 / 286
bladder	100%	20111.38	21 / 21	95%	53.47	481 / 504
adrenal gland	100%	16570.20	258 / 258	95%	56.10	218 / 230
pancreas	74%	5349.98	244 / 328	98%	69.19	175 / 178
liver	68%	4804.72	154 / 226	98%	43.38	396 / 406
adipose	100%	22319.14	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	97.91	80 / 80
lymph node	0%	0	0 / 0	100%	67.62	29 / 29
spleen	100%	16999.33	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	58.32	45 / 45
ureter	0%	0	0 / 0	100%	23.25	1 / 1
blood vessel	100%	24418.51	1334 / 1335	0%	0	0 / 0
heart	99%	16436.77	850 / 861	0%	0	0 / 0
peripheral blood	59%	7532.12	551 / 929	0%	0	0 / 0
muscle	39%	2321.46	315 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0051693	Biological process	actin filament capping
GO_0030036	Biological process	actin cytoskeleton organization
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0035580	Cellular component	specific granule lumen
GO_0016020	Cellular component	membrane
GO_0070062	Cellular component	extracellular exosome
GO_1903561	Cellular component	extracellular vesicle
GO_0030864	Cellular component	cortical actin cytoskeleton
GO_1904724	Cellular component	tertiary granule lumen
GO_0005829	Cellular component	cytosol
GO_0015630	Cellular component	microtubule cytoskeleton
GO_0042995	Cellular component	cell projection
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0030054	Cellular component	cell junction
GO_0008091	Cellular component	spectrin
GO_0045296	Molecular function	cadherin binding
GO_0005200	Molecular function	structural constituent of cytoskeleton
GO_0051015	Molecular function	actin filament binding
GO_0005516	Molecular function	calmodulin binding
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding
GO_0003779	Molecular function	actin binding

IV. Literature review

[source]

Gene name	SPTAN1
Protein name	Spectrin alpha, non-erythrocytic 1 SPTAN1 protein Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)
Synonyms	NEAS SPTA2
Description	FUNCTION: Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
Accessions	ENST00000627441.3 ENST00000704204.1 A0A994J7B0 ENST00000635806.1 ENST00000706487.1 [Q13813-2] ENST00000637867.1 A0A0D9SFF6 ENST00000630804.2 ENST00000630981.1 A0A1B0GW19 A0A1B0GTD1 A0A994J6W6 A0A994J498 ENST00000637032.2 Q13813 ENST00000372731.8 [Q13813-1] A0A5F9ZHC3 A0A994J4G5 ENST00000636337.1 ENST00000704203.1 ENST00000630866.2 ENST00000636257.1 A0A0D9SGF6 A0A1B0GWE2 Q14917 ENST00000358161.9 [Q13813-3] ENST00000672130.1 A0A0D9SF54 ENST00000704206.1 ENST00000636483.1 A0A1B0GTB7 A0A0D9SFH4 ENST00000372739.7 [Q13813-2] ENST00000704205.1 ENST00000704202.1 ENST00000637903.1 ENST00000704207.1 A0A1B0GV13 A0A994J6W3 A0A1B0GUH3

SPTAN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review