SMARCB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0030071Biological processregulation of mitotic metaphase/anaphase transition
GO_0001835Biological processblastocyst hatching
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0045582Biological processpositive regulation of T cell differentiation
GO_0015074Biological processDNA integration
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_2000045Biological processregulation of G1/S transition of mitotic cell cycle
GO_0045663Biological processpositive regulation of myoblast differentiation
GO_0006338Biological processchromatin remodeling
GO_0070316Biological processregulation of G0 to G1 transition
GO_1902459Biological processpositive regulation of stem cell population maintenance
GO_0045597Biological processpositive regulation of cell differentiation
GO_0043923Biological processpositive regulation by host of viral transcription
GO_2000819Biological processregulation of nucleotide-excision repair
GO_0001188Biological processRNA polymerase I preinitiation complex assembly
GO_1901838Biological processpositive regulation of transcription of nucleolar large rRNA by RNA polymerase I
GO_0007399Biological processnervous system development
GO_0006337Biological processnucleosome disassembly
GO_0070365Biological processhepatocyte differentiation
GO_0039692Biological processsingle stranded viral RNA replication via double stranded DNA intermediate
GO_1902661Biological processpositive regulation of glucose mediated signaling pathway
GO_2000781Biological processpositive regulation of double-strand break repair
GO_0045815Biological processtranscription initiation-coupled chromatin remodeling
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005730Cellular componentnucleolus
GO_0071565Cellular componentnBAF complex
GO_0043073Cellular componentgerm cell nucleus
GO_0000228Cellular componentnuclear chromosome
GO_0071564Cellular componentnpBAF complex
GO_0000776Cellular componentkinetochore
GO_0032991Cellular componentprotein-containing complex
GO_0016514Cellular componentSWI/SNF complex
GO_0005654Cellular componentnucleoplasm
GO_0001650Cellular componentfibrillar center
GO_0016363Cellular componentnuclear matrix
GO_0016586Cellular componentRSC-type complex
GO_0035060Cellular componentbrahma complex
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0000785Cellular componentchromatin
GO_0001741Cellular componentXY body
GO_0140092Cellular componentbBAF complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0030957Molecular functionTat protein binding
GO_0031492Molecular functionnucleosomal DNA binding
GO_0042802Molecular functionidentical protein binding
GO_0002039Molecular functionp53 binding
GO_0001164Molecular functionRNA polymerase I core promoter sequence-specific DNA binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSMARCB1
Protein nameIntegrase interactor 1 protein isoform D
Integrase interactor 1 protein isoform F
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
SWI/SNF-related matrix-associated protein
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1)
Integrase interactor 1 protein isoform E
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (BRG1-associated factor 47) (BAF47) (Integrase interactor 1 protein) (SNF5 homolog) (hSNF5)
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SynonymsBAF47
INI1
SNF5L1
hCG_41099
DescriptionFUNCTION: Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1. .

AccessionsENST00000644036.2 [Q12824-1]
A0A2R8Y5N5
ENST00000629690.2
ENST00000630853.1
ENST00000642727.1
ENST00000407082.4
Q86WI7
ENST00000417137.6
A0A2R8YDN6
ENST00000344921.11
ENST00000263121.12
Q12824
Q6Q321
ENST00000635578.1
ENST00000618915.3 [Q12824-1]
ENST00000407422.8 [Q12824-2]
A0A0U1RRB8
A0A0U1RQQ2
ENST00000631333.2 [Q12824-2]
Q86WI8
Q86WI6
C9JTA6
A0A2R8Y5Z2
B5MCL5
ENST00000644619.1
A0A0G2JRV3
ENST00000634926.1
G5E975
ENST00000647057.1
A0A2R8YEE8
ENST00000644462.1
ENST00000629656.2
A0A0G2JSE9