SHISA5 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	29 studies	28% ± 12%	Explore
natural killer cell	26 studies	31% ± 12%	Explore
CD8-positive, alpha-beta T cell	24 studies	31% ± 11%	Explore
CD4-positive, alpha-beta T cell	22 studies	27% ± 7%	Explore
regulatory T cell	19 studies	34% ± 10%	Explore
B cell	16 studies	27% ± 8%	Explore
mature NK T cell	16 studies	32% ± 12%	Explore
non-classical monocyte	15 studies	30% ± 12%	Explore
naive B cell	15 studies	28% ± 7%	Explore
memory B cell	14 studies	24% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	39% ± 13%	Explore
T cell	14 studies	28% ± 8%	Explore
fibroblast	13 studies	28% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	31% ± 12%	Explore
classical monocyte	12 studies	29% ± 11%	Explore
gamma-delta T cell	12 studies	37% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	33% ± 10%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	32% ± 5%	Explore
capillary endothelial cell	11 studies	24% ± 10%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	31% ± 8%	Explore
basal cell	10 studies	32% ± 12%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	29% ± 7%	Explore
mucosal invariant T cell	10 studies	34% ± 9%	Explore
macrophage	9 studies	22% ± 7%	Explore
pericyte	9 studies	22% ± 3%	Explore
endothelial cell of artery	9 studies	27% ± 5%	Explore
vein endothelial cell	9 studies	27% ± 10%	Explore
ciliated cell	7 studies	29% ± 9%	Explore
monocyte	7 studies	24% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	36% ± 12%	Explore
connective tissue cell	7 studies	23% ± 4%	Explore
endothelial cell of vascular tree	7 studies	24% ± 6%	Explore
epithelial cell	7 studies	36% ± 16%	Explore
plasmablast	6 studies	36% ± 22%	Explore
plasmacytoid dendritic cell	6 studies	24% ± 5%	Explore
T follicular helper cell	6 studies	28% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	33% ± 11%	Explore
exhausted T cell	5 studies	42% ± 4%	Explore
conventional dendritic cell	5 studies	28% ± 11%	Explore
neuron	5 studies	36% ± 16%	Explore
smooth muscle cell	5 studies	22% ± 3%	Explore
myofibroblast cell	5 studies	24% ± 6%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	41% ± 9%	Explore
respiratory goblet cell	4 studies	24% ± 14%	Explore
secretory cell	4 studies	29% ± 9%	Explore
precursor B cell	4 studies	22% ± 6%	Explore
myeloid cell	4 studies	24% ± 6%	Explore
retinal pigment epithelial cell	4 studies	33% ± 14%	Explore
abnormal cell	4 studies	41% ± 11%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	46% ± 4%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	37% ± 2%	Explore
goblet cell	4 studies	24% ± 7%	Explore
hematopoietic stem cell	4 studies	26% ± 6%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	31% ± 7%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	31% ± 15%	Explore
plasma cell	3 studies	32% ± 4%	Explore
platelet	3 studies	18% ± 2%	Explore
pancreatic A cell	3 studies	36% ± 6%	Explore
glomerular endothelial cell	3 studies	19% ± 1%	Explore
progenitor cell	3 studies	16% ± 1%	Explore
immature B cell	3 studies	33% ± 8%	Explore
intraepithelial lymphocyte	3 studies	27% ± 10%	Explore
GABAergic neuron	3 studies	22% ± 5%	Explore
dendritic cell	3 studies	35% ± 9%	Explore
oligodendrocyte precursor cell	3 studies	23% ± 10%	Explore
T-helper 1 cell	3 studies	28% ± 12%	Explore
T-helper 17 cell	3 studies	19% ± 4%	Explore
double negative thymocyte	3 studies	41% ± 8%	Explore
astrocyte	3 studies	20% ± 2%	Explore
enteroendocrine cell	3 studies	27% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	15 studies	30% ± 8%	Explore
lung	9 studies	24% ± 6%	Explore
lymph node	4 studies	22% ± 4%	Explore
intestine	4 studies	22% ± 9%	Explore
pancreas	3 studies	33% ± 10%	Explore
placenta	3 studies	35% ± 11%	Explore
brain	3 studies	24% ± 4%	Explore
liver	3 studies	23% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	9844.90	1445 / 1445	100%	113.76	183 / 183
lung	100%	9885.54	578 / 578	100%	134.17	1155 / 1155
stomach	100%	5599.72	359 / 359	100%	139.81	286 / 286
thymus	100%	7923.99	653 / 653	100%	158.85	605 / 605
uterus	100%	9179.89	170 / 170	100%	181.80	459 / 459
prostate	100%	11195.13	245 / 245	100%	156.17	501 / 502
ovary	100%	7612.68	180 / 180	100%	166.05	429 / 430
liver	100%	6483.42	226 / 226	100%	102.52	405 / 406
skin	100%	6559.11	1808 / 1809	100%	163.99	471 / 472
intestine	100%	7168.12	966 / 966	100%	157.02	525 / 527
brain	100%	5270.35	2631 / 2642	100%	113.53	705 / 705
bladder	100%	11376.48	21 / 21	99%	245.05	501 / 504
breast	100%	8031.92	459 / 459	99%	151.79	1107 / 1118
kidney	100%	8586.99	89 / 89	99%	119.31	889 / 901
adrenal gland	100%	6569.58	258 / 258	97%	153.07	223 / 230
pancreas	97%	3115.48	317 / 328	99%	152.10	177 / 178
adipose	100%	8660.44	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	87.45	80 / 80
lymph node	0%	0	0 / 0	100%	123.62	29 / 29
spleen	100%	10777.89	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	166.74	45 / 45
ureter	0%	0	0 / 0	100%	398.84	1 / 1
blood vessel	100%	8964.78	1334 / 1335	0%	0	0 / 0
peripheral blood	100%	19897.01	926 / 929	0%	0	0 / 0
heart	99%	4301.10	853 / 861	0%	0	0 / 0
muscle	40%	739.17	323 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0042771	Biological process	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO_0043123	Biological process	positive regulation of canonical NF-kappaB signal transduction
GO_0005788	Cellular component	endoplasmic reticulum lumen
GO_0005783	Cellular component	endoplasmic reticulum
GO_0031965	Cellular component	nuclear membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SHISA5
Protein name	Shisa family member 5 Protein shisa-5 (Scotin) Protein shisa-5 (Putative NF-kappa-B-activating protein 120) (Scotin)
Synonyms	PSEC0133 SCOTIN
Description	FUNCTION: Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis. . FUNCTION: Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis. .
Accessions	ENST00000415268.1 ENST00000443308.6 [Q8N114-5] ENST00000426002.5 [Q8N114-3] ENST00000296444.7 [Q8N114-1] ENST00000417841.5 F8WDS1 F8WFD9 C9IZ46 ENST00000417962.5 ENST00000424965.5 F8WCE2 ENST00000441507.1 ENST00000619810.4 [Q8N114-2] ENST00000444115.5 [Q8N114-2] H7C2R0 ENST00000442747.5 [Q8N114-2] Q8N114

SHISA5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review