SERINC3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	38 studies	31% ± 12%	Explore
fibroblast	22 studies	26% ± 10%	Explore
pericyte	21 studies	27% ± 9%	Explore
natural killer cell	19 studies	20% ± 3%	Explore
mast cell	16 studies	27% ± 9%	Explore
endothelial cell of lymphatic vessel	16 studies	26% ± 8%	Explore
regulatory T cell	15 studies	21% ± 4%	Explore
macrophage	14 studies	20% ± 4%	Explore
smooth muscle cell	14 studies	22% ± 6%	Explore
classical monocyte	13 studies	21% ± 7%	Explore
capillary endothelial cell	12 studies	29% ± 6%	Explore
vein endothelial cell	12 studies	25% ± 8%	Explore
plasmacytoid dendritic cell	12 studies	25% ± 8%	Explore
gamma-delta T cell	11 studies	23% ± 8%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	21% ± 4%	Explore
endothelial cell of artery	10 studies	31% ± 6%	Explore
endothelial cell of vascular tree	10 studies	26% ± 9%	Explore
oligodendrocyte	10 studies	27% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	21% ± 6%	Explore
basal cell	9 studies	28% ± 9%	Explore
ciliated cell	9 studies	28% ± 10%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	19% ± 3%	Explore
non-classical monocyte	9 studies	23% ± 9%	Explore
CD4-positive, alpha-beta T cell	9 studies	21% ± 5%	Explore
mature NK T cell	9 studies	19% ± 2%	Explore
glutamatergic neuron	9 studies	42% ± 22%	Explore
CD8-positive, alpha-beta T cell	9 studies	22% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	19% ± 3%	Explore
epithelial cell	8 studies	37% ± 16%	Explore
T cell	7 studies	22% ± 7%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	21% ± 5%	Explore
mucosal invariant T cell	7 studies	20% ± 2%	Explore
myofibroblast cell	7 studies	22% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	20% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	22% ± 3%	Explore
T follicular helper cell	6 studies	18% ± 2%	Explore
goblet cell	6 studies	26% ± 8%	Explore
connective tissue cell	6 studies	20% ± 3%	Explore
monocyte	5 studies	20% ± 3%	Explore
neutrophil	5 studies	21% ± 4%	Explore
secretory cell	5 studies	28% ± 10%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	19% ± 4%	Explore
conventional dendritic cell	5 studies	30% ± 12%	Explore
hematopoietic stem cell	5 studies	25% ± 5%	Explore
abnormal cell	5 studies	26% ± 11%	Explore
neuron	5 studies	30% ± 12%	Explore
B cell	4 studies	19% ± 5%	Explore
type I pneumocyte	4 studies	23% ± 3%	Explore
hematopoietic precursor cell	4 studies	24% ± 9%	Explore
leukocyte	4 studies	18% ± 1%	Explore
exhausted T cell	4 studies	23% ± 3%	Explore
retinal ganglion cell	4 studies	53% ± 27%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	20% ± 3%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	20% ± 5%	Explore
GABAergic neuron	4 studies	47% ± 16%	Explore
enteroendocrine cell	4 studies	25% ± 8%	Explore
interneuron	4 studies	41% ± 22%	Explore
ionocyte	3 studies	30% ± 2%	Explore
respiratory goblet cell	3 studies	27% ± 11%	Explore
pancreatic A cell	3 studies	41% ± 12%	Explore
type B pancreatic cell	3 studies	43% ± 12%	Explore
glomerular endothelial cell	3 studies	39% ± 2%	Explore
podocyte	3 studies	29% ± 8%	Explore
plasma cell	3 studies	27% ± 9%	Explore
pro-B cell	3 studies	21% ± 0%	Explore
lymphocyte	3 studies	25% ± 5%	Explore
innate lymphoid cell	3 studies	20% ± 2%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	18% ± 4%	Explore
granulocyte	3 studies	26% ± 1%	Explore
dendritic cell	3 studies	37% ± 16%	Explore
megakaryocyte	3 studies	31% ± 11%	Explore
group 3 innate lymphoid cell	3 studies	25% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	20% ± 4%	Explore
double negative thymocyte	3 studies	27% ± 9%	Explore
platelet	3 studies	23% ± 6%	Explore
astrocyte	3 studies	24% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	9 studies	22% ± 6%	Explore
brain	9 studies	36% ± 18%	Explore
lung	8 studies	27% ± 6%	Explore
kidney	4 studies	20% ± 4%	Explore
bone marrow	4 studies	17% ± 2%	Explore
eye	4 studies	21% ± 5%	Explore
uterus	4 studies	24% ± 8%	Explore
intestine	4 studies	20% ± 6%	Explore
liver	4 studies	27% ± 12%	Explore
pancreas	3 studies	43% ± 12%	Explore
lymph node	3 studies	21% ± 4%	Explore
breast	3 studies	16% ± 0%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	12940.07	258 / 258	100%	170.13	230 / 230
breast	100%	13749.53	459 / 459	100%	172.56	1118 / 1118
esophagus	100%	11118.03	1445 / 1445	100%	144.46	183 / 183
lung	100%	12104.73	578 / 578	100%	126.60	1155 / 1155
stomach	100%	7572.61	359 / 359	100%	153.70	286 / 286
brain	100%	10126.50	2640 / 2642	100%	149.24	705 / 705
intestine	100%	9774.39	966 / 966	100%	157.00	526 / 527
bladder	100%	10162.33	21 / 21	100%	136.60	503 / 504
prostate	100%	9058.87	245 / 245	100%	137.73	501 / 502
uterus	100%	11101.37	170 / 170	100%	109.19	458 / 459
ovary	100%	10141.64	180 / 180	100%	85.94	429 / 430
liver	100%	5369.23	226 / 226	100%	89.09	405 / 406
thymus	100%	11322.12	653 / 653	100%	150.61	603 / 605
kidney	100%	5775.74	89 / 89	100%	121.51	897 / 901
skin	100%	13894.26	1809 / 1809	98%	138.65	462 / 472
pancreas	98%	4352.09	321 / 328	99%	142.45	177 / 178
adipose	100%	15412.07	1204 / 1204	0%	0	0 / 0
blood vessel	100%	15206.10	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	70.75	29 / 29
muscle	100%	9611.66	803 / 803	0%	0	0 / 0
spleen	100%	7870.44	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	99.35	45 / 45
ureter	0%	0	0 / 0	100%	44.77	1 / 1
heart	99%	7153.70	854 / 861	0%	0	0 / 0
peripheral blood	97%	6833.71	899 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	90%	56.17	72 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0009597	Biological process	detection of virus
GO_0051607	Biological process	defense response to virus
GO_0015825	Biological process	L-serine transport
GO_1902237	Biological process	positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO_0006564	Biological process	L-serine biosynthetic process
GO_0045087	Biological process	innate immune response
GO_0000139	Cellular component	Golgi membrane
GO_0016020	Cellular component	membrane
GO_0005886	Cellular component	plasma membrane
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0015194	Molecular function	L-serine transmembrane transporter activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SERINC3
Protein name	Serine incorporator 3 Serine incorporator 3 (Tumor differentially expressed protein 1) Alternative protein SERINC3
Synonyms	DIFF33 SBBI99 TDE1
Description	FUNCTION: Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm . .
Accessions	L8ECD5 ENST00000342374.5 [Q13530-1] ENST00000411544.5 Q13530 L8E9G1 Q5H936 ENST00000255175.5 [Q13530-1]

SERINC3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review