RNF149 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	42 studies	42% ± 16%	Explore
T cell	27 studies	26% ± 9%	Explore
natural killer cell	27 studies	24% ± 6%	Explore
CD4-positive, alpha-beta T cell	27 studies	28% ± 6%	Explore
CD8-positive, alpha-beta T cell	25 studies	26% ± 6%	Explore
classical monocyte	24 studies	41% ± 12%	Explore
non-classical monocyte	24 studies	58% ± 14%	Explore
monocyte	23 studies	45% ± 19%	Explore
conventional dendritic cell	21 studies	30% ± 11%	Explore
regulatory T cell	20 studies	32% ± 8%	Explore
plasmacytoid dendritic cell	19 studies	45% ± 15%	Explore
fibroblast	19 studies	25% ± 7%	Explore
endothelial cell	17 studies	27% ± 10%	Explore
dendritic cell	16 studies	41% ± 17%	Explore
mature NK T cell	14 studies	25% ± 6%	Explore
microglial cell	14 studies	42% ± 15%	Explore
myeloid cell	14 studies	46% ± 12%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	27% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	27% ± 7%	Explore
neutrophil	12 studies	57% ± 19%	Explore
mucosal invariant T cell	12 studies	30% ± 7%	Explore
gamma-delta T cell	12 studies	28% ± 7%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	31% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	31% ± 7%	Explore
epithelial cell	11 studies	34% ± 21%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	25% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	23% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	28% ± 6%	Explore
glutamatergic neuron	9 studies	42% ± 24%	Explore
B cell	8 studies	20% ± 5%	Explore
alveolar macrophage	8 studies	64% ± 15%	Explore
leukocyte	8 studies	32% ± 13%	Explore
GABAergic neuron	8 studies	38% ± 20%	Explore
mast cell	8 studies	24% ± 9%	Explore
basal cell	8 studies	32% ± 18%	Explore
adipocyte	8 studies	21% ± 4%	Explore
endothelial cell of lymphatic vessel	8 studies	29% ± 10%	Explore
oligodendrocyte	8 studies	26% ± 8%	Explore
mononuclear phagocyte	7 studies	41% ± 15%	Explore
ciliated cell	7 studies	28% ± 6%	Explore
type I pneumocyte	7 studies	27% ± 9%	Explore
astrocyte	7 studies	29% ± 11%	Explore
plasma cell	6 studies	28% ± 7%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	25% ± 7%	Explore
interneuron	6 studies	35% ± 22%	Explore
T follicular helper cell	6 studies	29% ± 6%	Explore
club cell	6 studies	22% ± 7%	Explore
exhausted T cell	5 studies	31% ± 5%	Explore
abnormal cell	5 studies	27% ± 15%	Explore
lymphocyte	5 studies	36% ± 16%	Explore
retinal cone cell	5 studies	25% ± 6%	Explore
intermediate monocyte	5 studies	56% ± 27%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	37% ± 8%	Explore
type II pneumocyte	5 studies	24% ± 8%	Explore
pericyte	5 studies	26% ± 8%	Explore
smooth muscle cell	5 studies	22% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	26% ± 7%	Explore
squamous epithelial cell	4 studies	38% ± 19%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	38% ± 9%	Explore
innate lymphoid cell	4 studies	20% ± 2%	Explore
oligodendrocyte precursor cell	4 studies	29% ± 8%	Explore
goblet cell	4 studies	32% ± 24%	Explore
T-helper 17 cell	4 studies	23% ± 5%	Explore
secretory cell	3 studies	24% ± 3%	Explore
plasmablast	3 studies	32% ± 15%	Explore
neuron	3 studies	34% ± 13%	Explore
GABAergic interneuron	3 studies	20% ± 4%	Explore
cardiac muscle cell	3 studies	20% ± 4%	Explore
mesothelial cell	3 studies	24% ± 5%	Explore
tissue-resident macrophage	3 studies	53% ± 14%	Explore
hepatocyte	3 studies	47% ± 26%	Explore
inflammatory macrophage	3 studies	34% ± 7%	Explore
granulocyte	3 studies	22% ± 4%	Explore
adventitial cell	3 studies	20% ± 4%	Explore
group 3 innate lymphoid cell	3 studies	22% ± 3%	Explore
transit amplifying cell	3 studies	35% ± 26%	Explore
brush cell	3 studies	26% ± 7%	Explore
T-helper 1 cell	3 studies	33% ± 4%	Explore
memory B cell	3 studies	16% ± 1%	Explore
mucus secreting cell	3 studies	23% ± 5%	Explore
renal principal cell	3 studies	19% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	16 studies	27% ± 9%	Explore
brain	15 studies	32% ± 18%	Explore
lung	13 studies	29% ± 8%	Explore
liver	5 studies	29% ± 15%	Explore
kidney	4 studies	26% ± 9%	Explore
heart	4 studies	22% ± 4%	Explore
adipose	4 studies	28% ± 4%	Explore
lymph node	3 studies	33% ± 12%	Explore
breast	3 studies	19% ± 1%	Explore
intestine	3 studies	19% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	2501.14	21 / 21	100%	52.50	504 / 504
breast	100%	2736.55	459 / 459	100%	42.09	1118 / 1118
intestine	100%	2339.84	966 / 966	100%	42.79	527 / 527
lung	100%	5569.79	578 / 578	100%	46.41	1155 / 1155
ovary	100%	2594.81	180 / 180	100%	25.57	430 / 430
prostate	100%	2273.69	245 / 245	100%	32.81	502 / 502
stomach	100%	1981.82	359 / 359	100%	39.68	286 / 286
esophagus	100%	2813.10	1444 / 1445	100%	50.26	183 / 183
uterus	100%	2311.97	170 / 170	100%	44.22	458 / 459
liver	100%	1854.52	226 / 226	100%	25.29	405 / 406
thymus	100%	2177.87	652 / 653	99%	30.03	601 / 605
pancreas	100%	1931.51	327 / 328	99%	53.77	177 / 178
kidney	100%	2133.69	89 / 89	98%	51.97	884 / 901
skin	100%	3680.01	1809 / 1809	97%	23.75	458 / 472
adrenal gland	100%	2362.97	258 / 258	97%	17.28	223 / 230
brain	93%	1134.23	2452 / 2642	82%	13.69	581 / 705
adipose	100%	3366.40	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	30.32	29 / 29
peripheral blood	100%	19250.26	929 / 929	0%	0	0 / 0
spleen	100%	9116.05	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	38.20	45 / 45
ureter	0%	0	0 / 0	100%	32.40	1 / 1
blood vessel	100%	2193.31	1332 / 1335	0%	0	0 / 0
heart	93%	1254.83	804 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	89%	16.38	71 / 80
muscle	82%	746.99	661 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0043409	Biological process	negative regulation of MAPK cascade
GO_0016567	Biological process	protein ubiquitination
GO_0006511	Biological process	ubiquitin-dependent protein catabolic process
GO_0071466	Biological process	cellular response to xenobiotic stimulus
GO_0031647	Biological process	regulation of protein stability
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005770	Cellular component	late endosome
GO_0005794	Cellular component	Golgi apparatus
GO_0016020	Cellular component	membrane
GO_0005737	Cellular component	cytoplasm
GO_0061630	Molecular function	ubiquitin protein ligase activity
GO_0046872	Molecular function	metal ion binding

IV. Literature review

[source]

Gene name	RNF149
Protein name	Ring finger protein 149 E3 ubiquitin-protein ligase RNF149 (EC 2.3.2.27) (DNA polymerase-transactivated protein 2) (RING finger protein 149) (RING-type E3 ubiquitin transferase RNF149)
Synonyms	DNAPTP2
Description	FUNCTION: E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation. .
Accessions	F8WCD0 Q8NC42 ENST00000295317.4 ENST00000424632.5

RNF149 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review