RNF10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051865Biological processprotein autoubiquitination
GO_0031643Biological processpositive regulation of myelination
GO_0006513Biological processprotein monoubiquitination
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0010626Biological processnegative regulation of Schwann cell proliferation
GO_1990116Biological processribosome-associated ubiquitin-dependent protein catabolic process
GO_0099527Biological processpostsynapse to nucleus signaling pathway
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0098978Cellular componentglutamatergic synapse
GO_0022626Cellular componentcytosolic ribosome
GO_0099147Cellular componentextrinsic component of postsynaptic density membrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005515Molecular functionprotein binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameRNF10
Protein nameE3 ubiquitin-protein ligase RNF10 (RING finger protein 10)
E3 ubiquitin-protein ligase RNF10 (EC 2.3.2.27) (RING finger protein 10)
Ring finger protein 10
SynonymsKIAA0262
hCG_27770
RIE2
DescriptionFUNCTION: E3 ubiquitin-protein ligase that catalyzes monoubiquitination of 40S ribosomal proteins RPS2/us5 and RPS3/us3 in response to ribosome stalling . Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): RNF10 acts by mediating monoubiquitination of RPS2/us5 and RPS3/us3, promoting their degradation by the proteasome . Also promotes ubiquitination of 40S ribosomal proteins in response to ribosome stalling during translation elongation . The action of RNF10 in iRQC is counteracted by USP10 . May also act as a transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression (By similarity). Acts as a regulator of Schwann cell differentiation and myelination (By similarity). .

AccessionsENST00000538796.5
H0YGL7
H0YG28
ENST00000545419.5
H0YGX5
ENST00000538254.1
ENST00000325954.9 [Q8N5U6-1]
H0YF69
ENST00000537740.1
A0A024RBP0
A0A0G2JKT9
H0YFQ9
F5H5Z1
F5H3A4
ENST00000536869.5
ENST00000542438.1
ENST00000540046.5
ENST00000546262.6
F5H510
ENST00000413266.6 [Q8N5U6-2]
Q8N5U6
ENST00000539486.1
ENST00000542207.5
ENST00000537997.1
F5H5P6
H0YFN9