RNASET2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	45 studies	54% ± 23%	Explore
B cell	40 studies	48% ± 17%	Explore
conventional dendritic cell	27 studies	66% ± 19%	Explore
CD4-positive, alpha-beta T cell	27 studies	38% ± 13%	Explore
classical monocyte	25 studies	51% ± 16%	Explore
plasmacytoid dendritic cell	25 studies	79% ± 17%	Explore
non-classical monocyte	24 studies	75% ± 20%	Explore
regulatory T cell	23 studies	39% ± 10%	Explore
monocyte	22 studies	50% ± 15%	Explore
T cell	21 studies	29% ± 8%	Explore
dendritic cell	21 studies	59% ± 23%	Explore
natural killer cell	20 studies	21% ± 5%	Explore
naive B cell	20 studies	42% ± 12%	Explore
memory B cell	19 studies	56% ± 12%	Explore
CD8-positive, alpha-beta T cell	19 studies	26% ± 7%	Explore
plasma cell	17 studies	36% ± 18%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	16 studies	36% ± 11%	Explore
microglial cell	16 studies	65% ± 24%	Explore
myeloid cell	15 studies	49% ± 21%	Explore
mast cell	13 studies	22% ± 5%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	38% ± 14%	Explore
neutrophil	11 studies	42% ± 15%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	27% ± 7%	Explore
mature NK T cell	10 studies	23% ± 6%	Explore
gamma-delta T cell	10 studies	27% ± 3%	Explore
mucosal invariant T cell	10 studies	30% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	28% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	23% ± 3%	Explore
epithelial cell	8 studies	49% ± 24%	Explore
leukocyte	8 studies	45% ± 14%	Explore
T follicular helper cell	8 studies	48% ± 9%	Explore
plasmablast	7 studies	34% ± 14%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	22% ± 4%	Explore
alveolar macrophage	6 studies	39% ± 8%	Explore
CD4-positive helper T cell	6 studies	31% ± 6%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	35% ± 15%	Explore
mononuclear phagocyte	6 studies	58% ± 29%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	29% ± 11%	Explore
abnormal cell	6 studies	39% ± 17%	Explore
innate lymphoid cell	6 studies	34% ± 17%	Explore
immature B cell	6 studies	51% ± 16%	Explore
ciliated cell	6 studies	40% ± 26%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	45% ± 16%	Explore
hematopoietic precursor cell	5 studies	43% ± 18%	Explore
secretory cell	5 studies	43% ± 27%	Explore
fibroblast	5 studies	21% ± 4%	Explore
intermediate monocyte	5 studies	67% ± 24%	Explore
goblet cell	5 studies	31% ± 8%	Explore
basal cell	5 studies	27% ± 13%	Explore
platelet	4 studies	20% ± 7%	Explore
exhausted T cell	4 studies	37% ± 13%	Explore
IgA plasma cell	4 studies	28% ± 6%	Explore
IgG plasma cell	4 studies	36% ± 9%	Explore
hematopoietic stem cell	4 studies	24% ± 3%	Explore
pro-B cell	4 studies	25% ± 5%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	24% ± 4%	Explore
intestinal crypt stem cell	4 studies	25% ± 5%	Explore
T-helper 17 cell	4 studies	36% ± 11%	Explore
respiratory goblet cell	3 studies	24% ± 6%	Explore
monocyte-derived dendritic cell	3 studies	68% ± 16%	Explore
endothelial cell	3 studies	41% ± 27%	Explore
common myeloid progenitor	3 studies	39% ± 13%	Explore
lymphocyte	3 studies	30% ± 14%	Explore
precursor B cell	3 studies	35% ± 9%	Explore
tissue-resident macrophage	3 studies	59% ± 27%	Explore
intraepithelial lymphocyte	3 studies	24% ± 4%	Explore
GABAergic neuron	3 studies	31% ± 15%	Explore
glutamatergic neuron	3 studies	25% ± 8%	Explore
granulocyte	3 studies	35% ± 13%	Explore
granulocyte monocyte progenitor cell	3 studies	50% ± 21%	Explore
group 3 innate lymphoid cell	3 studies	39% ± 8%	Explore
T-helper 1 cell	3 studies	45% ± 12%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	40% ± 14%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	26% ± 3%	Explore
transit amplifying cell	3 studies	22% ± 6%	Explore
connective tissue cell	3 studies	26% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	19 studies	39% ± 13%	Explore
lung	13 studies	24% ± 5%	Explore
intestine	9 studies	27% ± 8%	Explore
brain	9 studies	32% ± 24%	Explore
bone marrow	5 studies	24% ± 10%	Explore
kidney	4 studies	33% ± 9%	Explore
uterus	4 studies	37% ± 21%	Explore
lymph node	4 studies	45% ± 7%	Explore
placenta	3 studies	23% ± 6%	Explore
liver	3 studies	30% ± 6%	Explore
breast	3 studies	23% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	3393.80	245 / 245	99%	9.11	498 / 502
ovary	100%	2214.93	180 / 180	99%	15.15	426 / 430
intestine	100%	3112.82	962 / 966	99%	12.55	522 / 527
stomach	99%	3124.98	355 / 359	98%	10.80	280 / 286
pancreas	100%	1844.80	328 / 328	96%	13.86	171 / 178
bladder	100%	2017.90	21 / 21	91%	10.00	459 / 504
thymus	100%	3695.43	653 / 653	88%	5.69	535 / 605
lung	100%	3152.91	577 / 578	88%	6.43	1012 / 1155
breast	97%	1672.81	445 / 459	89%	6.67	999 / 1118
kidney	98%	1570.67	87 / 89	87%	21.59	786 / 901
uterus	99%	1968.49	169 / 170	84%	8.45	387 / 459
brain	91%	2068.77	2405 / 2642	91%	8.86	640 / 705
adrenal gland	98%	1424.19	253 / 258	76%	6.61	175 / 230
esophagus	90%	1155.65	1298 / 1445	75%	5.76	138 / 183
skin	99%	1609.81	1783 / 1809	52%	3.11	246 / 472
liver	85%	874.28	193 / 226	50%	3.27	204 / 406
lymph node	0%	0	0 / 0	100%	15.70	29 / 29
peripheral blood	100%	19007.48	929 / 929	0%	0	0 / 0
spleen	100%	14531.99	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	3.33	1 / 1
adipose	98%	2030.66	1180 / 1204	0%	0	0 / 0
blood vessel	90%	1316.00	1208 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	69%	3.61	31 / 45
heart	69%	701.23	593 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	48%	2.11	38 / 80
muscle	4%	23.77	29 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0045087	Biological process	innate immune response
GO_0006401	Biological process	RNA catabolic process
GO_0035578	Cellular component	azurophil granule lumen
GO_0005615	Cellular component	extracellular space
GO_0043202	Cellular component	lysosomal lumen
GO_0005764	Cellular component	lysosome
GO_0005758	Cellular component	mitochondrial intermembrane space
GO_0005788	Cellular component	endoplasmic reticulum lumen
GO_0070062	Cellular component	extracellular exosome
GO_0005576	Cellular component	extracellular region
GO_0003723	Molecular function	RNA binding
GO_0004521	Molecular function	RNA endonuclease activity
GO_0004540	Molecular function	RNA nuclease activity
GO_0033897	Molecular function	ribonuclease T2 activity

IV. Literature review

[source]

Gene name	RNASET2
Protein name	Ribonuclease T2 Ribonuclease T2 (EC 4.6.1.19) (Ribonuclease 6)
Synonyms	RNASE6PL hCG_15018
Description	FUNCTION: Ribonuclease that plays an essential role in innate immune response by recognizing and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8 . Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides . In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8 . Also plays a key role in degradation of mitochondrial RNA and processing of non-coding RNA imported from the cytosol into mitochondria . Participates as well in degradation of mitochondrion-associated cytosolic rRNAs . .
Accessions	ENST00000478180.6 ENST00000028008.9 ENST00000421787.5 [O00584-2] A0A804HKZ2 ENST00000508775.6 [O00584-1] J3QQ64 ENST00000684236.1 ENST00000476238.6 [O00584-1] ENST00000611959.2 A0A087WWI1 ENST00000683770.1 D6RHI9 ENST00000620173.5 A0A087WZM2 A0A804HJZ7 ENST00000682774.1 O00584 D6REQ6 A0A804HJ89 ENST00000366855.10

RNASET2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review