RAB11B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0044070Biological processregulation of monoatomic anion transport
GO_2000008Biological processregulation of protein localization to cell surface
GO_0032456Biological processendocytic recycling
GO_0071468Biological processcellular response to acidic pH
GO_0032402Biological processmelanosome transport
GO_0035773Biological processinsulin secretion involved in cellular response to glucose stimulus
GO_0045055Biological processregulated exocytosis
GO_0090150Biological processestablishment of protein localization to membrane
GO_0150093Biological processamyloid-beta clearance by transcytosis
GO_0033572Biological processtransferrin transport
GO_0045054Biological processconstitutive secretory pathway
GO_0001881Biological processreceptor recycling
GO_2001135Biological processregulation of endocytic recycling
GO_0055037Cellular componentrecycling endosome
GO_0030672Cellular componentsynaptic vesicle membrane
GO_0070062Cellular componentextracellular exosome
GO_0055038Cellular componentrecycling endosome membrane
GO_0005794Cellular componentGolgi apparatus
GO_0005829Cellular componentcytosol
GO_0008021Cellular componentsynaptic vesicle
GO_0045335Cellular componentphagocytic vesicle
GO_0030670Cellular componentphagocytic vesicle membrane
GO_0019003Molecular functionGDP binding
GO_0045296Molecular functioncadherin binding
GO_0003925Molecular functionG protein activity
GO_0031489Molecular functionmyosin V binding
GO_0005525Molecular functionGTP binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameRAB11B
Protein nameRas-related protein Rab-11B (EC 3.6.5.2) (GTP-binding protein YPT3)
RAB11B, member RAS oncogene family
SynonymsYPT3
DescriptionFUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis. Promotes Rabin8/RAB3IP preciliary vesicular trafficking to mother centriole by forming a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, thereby regulating ciliogenesis initiation (Probable). On the contrary, upon LPAR1 receptor signaling pathway activation, interaction with phosphorylated WDR44 prevents Rab11-RAB3IP-RAB11FIP3 complex formation and cilia growth (Probable). .

AccessionsENST00000328024.11 [Q15907-1]
M0R377
Q15907
M0R2D0
ENST00000601897.1
ENST00000600719.5
ENST00000594216.1 [Q15907-2]