PTBP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0033119Biological processnegative regulation of RNA splicing
GO_0006397Biological processmRNA processing
GO_0070886Biological processpositive regulation of calcineurin-NFAT signaling cascade
GO_0051148Biological processnegative regulation of muscle cell differentiation
GO_0000381Biological processregulation of alternative mRNA splicing, via spliceosome
GO_0008380Biological processRNA splicing
GO_0045595Biological processregulation of cell differentiation
GO_0043484Biological processregulation of RNA splicing
GO_0048025Biological processnegative regulation of mRNA splicing, via spliceosome
GO_0075522Biological processIRES-dependent viral translational initiation
GO_0035307Biological processpositive regulation of protein dephosphorylation
GO_0005730Cellular componentnucleolus
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0003729Molecular functionmRNA binding
GO_0003723Molecular functionRNA binding
GO_0036002Molecular functionpre-mRNA binding
GO_0008187Molecular functionpoly-pyrimidine tract binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePTBP1
Protein namePolypyrimidine tract-binding protein 1
Polypyrimidine tract-binding protein 1 (PTB) (57 kDa RNA-binding protein PPTB-1) (Heterogeneous nuclear ribonucleoprotein I) (hnRNP I)
Polypyrimidine tract binding protein 1
SynonymshCG_20560
PTB
DescriptionFUNCTION: Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10 . Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9 . Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform . In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation . .

AccessionsENST00000676227.1
A0A087WUW5
ENST00000589575.5
ENST00000394601.8 [P26599-2]
ENST00000349038.8 [P26599-1]
ENST00000635647.1
A0A6Q8PEX4
K7ELW5
A6NLN1
A0A087WTS6
ENST00000356948.11 [P26599-3]
A0A0U1RRM4
ENST00000585956.5
ENST00000585932.5
K7EK45
ENST00000677277.1
ENST00000587191.3
A0A7I2V621
K7ES59
ENST00000621737.4
A0A7I2V4H6
ENST00000679114.1
ENST00000585535.2
A0A0D9SF20
ENST00000350092.8
A0A087WU68
ENST00000586481.5
P26599
ENST00000627714.2
K7EKJ7