PQBP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048814Biological processregulation of dendrite morphogenesis
GO_0045087Biological processinnate immune response
GO_0031175Biological processneuron projection development
GO_0051607Biological processdefense response to virus
GO_0032481Biological processpositive regulation of type I interferon production
GO_0000380Biological processalternative mRNA splicing, via spliceosome
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006355Biological processregulation of DNA-templated transcription
GO_0002218Biological processactivation of innate immune response
GO_0043484Biological processregulation of RNA splicing
GO_0071360Biological processcellular response to exogenous dsRNA
GO_0002230Biological processpositive regulation of defense response to virus by host
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0071598Cellular componentneuronal ribonucleoprotein granule
GO_0005737Cellular componentcytoplasm
GO_0010494Cellular componentcytoplasmic stress granule
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0043021Molecular functionribonucleoprotein complex binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePQBP1
Protein namePolyglutamine-binding protein 1 (PQBP-1) (38 kDa nuclear protein containing a WW domain) (Npw38) (Polyglutamine tract-binding protein 1)
Polyglutamine binding protein 1 isoform 2
Polyglutamine binding protein 1
Polyglutamine-binding protein 1 (Polyglutamine tract-binding protein 1)
SynonymsJM26
hCG_19821
NPW38
DescriptionFUNCTION: Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development . Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species . May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery . May be involved in ATXN1 mutant-induced cell death . The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit . Involved in the assembly of cytoplasmic stress granule, possibly by participating in the transport of neuronal RNA granules . Also acts as an innate immune sensor of infection by retroviruses, such as HIV, by detecting the presence of reverse-transcribed DNA in the cytosol . Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production . .

AccessionsENST00000710049.1 [O60828-7]
ENST00000710038.1 [O60828-1]
ENST00000651767.1 [O60828-1]
ENST00000692023.1 [O60828-9]
ENST00000710039.1 [O60828-4]
ENST00000472742.6 [O60828-6]
O60828
ENST00000710041.1 [O60828-6]
ENST00000376566.8 [O60828-4]
ENST00000465859.2 [O60828-7]
ENST00000710044.1 [O60828-1]
ENST00000710033.1 [O60828-4]
Q4VY28
A0A0S2Z4V5
ENST00000710032.1 [O60828-1]
ENST00000443648.6 [O60828-1]
ENST00000396763.6 [O60828-1]
ENST00000456306.2
ENST00000470062.5 [O60828-6]
ENST00000710035.1 [O60828-1]
A0A0S2Z556
ENST00000247140.8 [O60828-4]
ENST00000443648
ENST00000447146.7 [O60828-1]
ENST00000710037.1 [O60828-9]
ENST00000710046.1 [O60828-1]
ENST00000710043.1 [O60828-6]
A0A5H1ZRR1
ENST00000710042.1 [O60828-1]
ENST00000376563.6 [O60828-1]
ENST00000218224.9 [O60828-1]
H7C053