PPP1R10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010667Biological processnegative regulation of cardiac muscle cell apoptotic process
GO_0032206Biological processpositive regulation of telomere maintenance
GO_1904290Biological processnegative regulation of mitotic DNA damage checkpoint
GO_0006606Biological processprotein import into nucleus
GO_0072357Cellular componentPTW/PP1 phosphatase complex
GO_0000781Cellular componentchromosome, telomeric region
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0004864Molecular functionprotein phosphatase inhibitor activity
GO_0003677Molecular functionDNA binding
GO_0008157Molecular functionprotein phosphatase 1 binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene namePPP1R10
Protein nameSerine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53) (PP1-binding protein of 114 kDa) (Phosphatase 1 nuclear targeting subunit) (Protein FB19) (p99)
Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53)
PPP1R10 protein
SynonymsCAT53
hCG_26006
PNUTS
FB19
DescriptionFUNCTION: Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity). .

FUNCTION: Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers. .

AccessionsENST00000420949.6
ENST00000376511.7
ENST00000429597.6
ENST00000426299.6
Q2L6I0
Q58F28
ENST00000383586.8
ENST00000449113.6
Q96QC0
ENST00000424446.6