PPCS | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	18 studies	20% ± 3%	Explore
macrophage	13 studies	25% ± 8%	Explore
classical monocyte	13 studies	26% ± 10%	Explore
B cell	13 studies	24% ± 5%	Explore
CD8-positive, alpha-beta T cell	13 studies	20% ± 3%	Explore
regulatory T cell	13 studies	20% ± 4%	Explore
naive B cell	12 studies	20% ± 3%	Explore
gamma-delta T cell	12 studies	22% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	20% ± 3%	Explore
non-classical monocyte	11 studies	32% ± 12%	Explore
CD4-positive, alpha-beta T cell	11 studies	20% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	22% ± 4%	Explore
conventional dendritic cell	10 studies	28% ± 15%	Explore
basal cell	9 studies	30% ± 17%	Explore
epithelial cell	9 studies	39% ± 20%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	9 studies	20% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	23% ± 4%	Explore
memory B cell	9 studies	20% ± 3%	Explore
mucosal invariant T cell	9 studies	19% ± 3%	Explore
plasmacytoid dendritic cell	9 studies	27% ± 8%	Explore
mature NK T cell	8 studies	20% ± 3%	Explore
fibroblast	8 studies	25% ± 11%	Explore
endothelial cell	7 studies	28% ± 10%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	21% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	22% ± 5%	Explore
T cell	6 studies	16% ± 1%	Explore
club cell	6 studies	23% ± 6%	Explore
ciliated cell	6 studies	36% ± 15%	Explore
monocyte	6 studies	21% ± 6%	Explore
T follicular helper cell	6 studies	18% ± 2%	Explore
respiratory goblet cell	5 studies	29% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	23% ± 2%	Explore
epithelial cell of proximal tubule	5 studies	28% ± 6%	Explore
kidney loop of Henle epithelial cell	5 studies	26% ± 7%	Explore
goblet cell	5 studies	26% ± 9%	Explore
enterocyte	5 studies	19% ± 4%	Explore
dendritic cell	5 studies	32% ± 16%	Explore
secretory cell	4 studies	33% ± 16%	Explore
plasma cell	4 studies	27% ± 10%	Explore
abnormal cell	4 studies	18% ± 3%	Explore
endothelial cell of lymphatic vessel	4 studies	21% ± 6%	Explore
innate lymphoid cell	4 studies	20% ± 3%	Explore
duct epithelial cell	3 studies	21% ± 9%	Explore
pancreatic A cell	3 studies	28% ± 3%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	19% ± 4%	Explore
hematopoietic precursor cell	3 studies	24% ± 5%	Explore
smooth muscle cell	3 studies	20% ± 1%	Explore
myeloid cell	3 studies	30% ± 12%	Explore
type II pneumocyte	3 studies	29% ± 14%	Explore
alveolar macrophage	3 studies	21% ± 1%	Explore
intraepithelial lymphocyte	3 studies	23% ± 4%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	24% ± 2%	Explore
endothelial cell of vascular tree	3 studies	18% ± 1%	Explore
exhausted T cell	3 studies	19% ± 3%	Explore
intermediate monocyte	3 studies	33% ± 16%	Explore
glutamatergic neuron	3 studies	25% ± 1%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	23% ± 5%	Explore
intestinal crypt stem cell	3 studies	22% ± 6%	Explore
mast cell	3 studies	23% ± 4%	Explore
hematopoietic stem cell	3 studies	19% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	19% ± 4%	Explore
double negative thymocyte	3 studies	24% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	13 studies	23% ± 6%	Explore
lung	9 studies	26% ± 13%	Explore
kidney	5 studies	20% ± 4%	Explore
intestine	4 studies	23% ± 8%	Explore
pancreas	3 studies	31% ± 2%	Explore
liver	3 studies	24% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	2517.75	459 / 459	100%	71.64	1118 / 1118
esophagus	100%	2101.33	1445 / 1445	100%	32.75	183 / 183
ovary	100%	1620.86	180 / 180	100%	55.70	430 / 430
pancreas	100%	1773.79	328 / 328	100%	45.99	178 / 178
prostate	100%	2532.13	245 / 245	100%	67.60	502 / 502
stomach	100%	2338.45	359 / 359	100%	43.81	286 / 286
uterus	100%	1839.62	170 / 170	100%	52.94	459 / 459
kidney	100%	3136.78	89 / 89	100%	46.27	900 / 901
thymus	100%	2438.15	653 / 653	100%	59.29	604 / 605
intestine	100%	2483.09	966 / 966	100%	49.25	526 / 527
bladder	100%	2204.57	21 / 21	100%	51.30	503 / 504
liver	100%	1733.78	226 / 226	100%	37.63	405 / 406
lung	99%	1804.28	575 / 578	100%	54.52	1155 / 1155
skin	100%	2453.54	1809 / 1809	99%	40.41	465 / 472
adrenal gland	100%	3170.72	258 / 258	97%	28.17	224 / 230
brain	100%	1312.27	2635 / 2642	81%	19.59	573 / 705
adipose	100%	2342.42	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	41.02	29 / 29
spleen	100%	2524.47	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	42.96	45 / 45
ureter	0%	0	0 / 0	100%	22.95	1 / 1
blood vessel	100%	2019.47	1334 / 1335	0%	0	0 / 0
muscle	99%	1256.00	796 / 803	0%	0	0 / 0
heart	96%	1324.83	826 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	93%	25.05	74 / 80
peripheral blood	85%	1297.47	793 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0015937	Biological process	coenzyme A biosynthetic process
GO_0006085	Biological process	acetyl-CoA biosynthetic process
GO_0003015	Biological process	heart process
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0004632	Molecular function	phosphopantothenate--cysteine ligase activity
GO_0042803	Molecular function	protein homodimerization activity
GO_0042802	Molecular function	identical protein binding
GO_0005524	Molecular function	ATP binding

IV. Literature review

[source]

Gene name	PPCS
Protein name	Phosphopantothenoylcysteine synthetase Phosphopantothenate--cysteine ligase (EC 6.3.2.51) (Phosphopantothenoylcysteine synthetase) (PPC synthetase)
Synonyms	COAB
Description	FUNCTION: Catalyzes the second step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine . Has a preference for ATP over CTP as a cosubstrate . .
Accessions	Q5VVM2 Q9HAB8 ENST00000372562.1 [Q9HAB8-2] ENST00000372556.3 Q5VVM3 ENST00000372561.4 [Q9HAB8-1] ENST00000372560.3

PPCS report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review