PHF20 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	35 studies	27% ± 10%	Explore
natural killer cell	33 studies	27% ± 7%	Explore
endothelial cell	27 studies	27% ± 10%	Explore
CD8-positive, alpha-beta T cell	27 studies	24% ± 8%	Explore
macrophage	26 studies	28% ± 14%	Explore
mast cell	24 studies	39% ± 12%	Explore
CD4-positive, alpha-beta T cell	23 studies	24% ± 7%	Explore
T cell	22 studies	24% ± 5%	Explore
fibroblast	19 studies	23% ± 7%	Explore
naive B cell	18 studies	26% ± 8%	Explore
memory B cell	17 studies	29% ± 7%	Explore
pericyte	16 studies	22% ± 9%	Explore
smooth muscle cell	16 studies	20% ± 4%	Explore
non-classical monocyte	16 studies	26% ± 12%	Explore
mature NK T cell	16 studies	27% ± 6%	Explore
gamma-delta T cell	15 studies	31% ± 11%	Explore
regulatory T cell	15 studies	23% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	30% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	28% ± 6%	Explore
classical monocyte	13 studies	23% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	22% ± 5%	Explore
endothelial cell of lymphatic vessel	12 studies	23% ± 7%	Explore
microglial cell	12 studies	35% ± 12%	Explore
mucosal invariant T cell	12 studies	27% ± 5%	Explore
myeloid cell	12 studies	29% ± 10%	Explore
monocyte	11 studies	27% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	29% ± 8%	Explore
conventional dendritic cell	10 studies	28% ± 18%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	30% ± 10%	Explore
plasmacytoid dendritic cell	10 studies	21% ± 9%	Explore
astrocyte	10 studies	28% ± 13%	Explore
leukocyte	9 studies	24% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	24% ± 8%	Explore
dendritic cell	9 studies	34% ± 16%	Explore
adipocyte	9 studies	26% ± 7%	Explore
ciliated cell	8 studies	25% ± 7%	Explore
type I pneumocyte	8 studies	25% ± 7%	Explore
oligodendrocyte	8 studies	28% ± 10%	Explore
glutamatergic neuron	7 studies	44% ± 23%	Explore
epithelial cell	7 studies	34% ± 14%	Explore
retinal cone cell	7 studies	32% ± 10%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	23% ± 7%	Explore
GABAergic neuron	7 studies	39% ± 18%	Explore
neuron	6 studies	36% ± 14%	Explore
interneuron	6 studies	35% ± 20%	Explore
hematopoietic stem cell	6 studies	25% ± 7%	Explore
myofibroblast cell	6 studies	22% ± 5%	Explore
innate lymphoid cell	6 studies	29% ± 8%	Explore
type II pneumocyte	6 studies	23% ± 5%	Explore
oligodendrocyte precursor cell	6 studies	25% ± 10%	Explore
hematopoietic precursor cell	5 studies	32% ± 15%	Explore
mononuclear phagocyte	5 studies	27% ± 7%	Explore
capillary endothelial cell	5 studies	18% ± 4%	Explore
retina horizontal cell	5 studies	24% ± 7%	Explore
retinal rod cell	5 studies	22% ± 3%	Explore
cardiac muscle cell	5 studies	24% ± 4%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	28% ± 13%	Explore
endothelial cell of vascular tree	5 studies	23% ± 12%	Explore
basal cell	5 studies	30% ± 16%	Explore
endothelial cell of artery	4 studies	22% ± 3%	Explore
vein endothelial cell	4 studies	25% ± 12%	Explore
lymphocyte	4 studies	43% ± 11%	Explore
granulocyte	4 studies	39% ± 17%	Explore
muscle cell	4 studies	32% ± 10%	Explore
abnormal cell	4 studies	27% ± 13%	Explore
connective tissue cell	4 studies	19% ± 1%	Explore
club cell	4 studies	21% ± 4%	Explore
T follicular helper cell	4 studies	26% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	26% ± 3%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	24% ± 9%	Explore
retinal bipolar neuron	3 studies	25% ± 5%	Explore
glial cell	3 studies	21% ± 4%	Explore
granule cell	3 studies	22% ± 8%	Explore
retinal ganglion cell	3 studies	40% ± 18%	Explore
mesothelial cell	3 studies	20% ± 4%	Explore
rod bipolar cell	3 studies	22% ± 3%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	23% ± 8%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	40% ± 16%	Explore
adventitial cell	3 studies	21% ± 3%	Explore
alveolar macrophage	3 studies	34% ± 9%	Explore
group 3 innate lymphoid cell	3 studies	41% ± 10%	Explore
goblet cell	3 studies	35% ± 21%	Explore
transit amplifying cell	3 studies	36% ± 23%	Explore
T-helper 17 cell	3 studies	28% ± 8%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	22% ± 4%	Explore
double negative thymocyte	3 studies	33% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	15 studies	23% ± 8%	Explore
brain	15 studies	30% ± 16%	Explore
lung	14 studies	22% ± 5%	Explore
eye	7 studies	26% ± 10%	Explore
intestine	5 studies	19% ± 4%	Explore
heart	4 studies	22% ± 4%	Explore
adipose	4 studies	31% ± 10%	Explore
liver	4 studies	28% ± 13%	Explore
bone marrow	3 studies	22% ± 3%	Explore
kidney	3 studies	19% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2627.79	1445 / 1445	100%	21.89	183 / 183
lung	100%	3141.96	578 / 578	100%	20.83	1155 / 1155
ovary	100%	2811.84	180 / 180	100%	18.63	430 / 430
prostate	100%	2565.53	245 / 245	100%	24.48	502 / 502
stomach	100%	1953.05	359 / 359	100%	23.17	286 / 286
uterus	100%	3304.14	170 / 170	100%	21.97	459 / 459
breast	100%	2904.09	459 / 459	100%	37.30	1117 / 1118
brain	100%	2427.92	2637 / 2642	100%	28.19	705 / 705
intestine	100%	2873.20	966 / 966	100%	21.94	526 / 527
bladder	100%	3246.76	21 / 21	100%	19.71	503 / 504
skin	100%	2980.54	1808 / 1809	100%	24.29	470 / 472
thymus	100%	2315.37	653 / 653	99%	17.94	601 / 605
kidney	100%	1498.94	89 / 89	98%	16.58	887 / 901
adrenal gland	100%	1910.60	258 / 258	97%	14.90	224 / 230
pancreas	83%	697.12	271 / 328	99%	17.93	176 / 178
liver	90%	722.14	203 / 226	89%	8.63	360 / 406
adipose	100%	2966.47	1204 / 1204	0%	0	0 / 0
blood vessel	100%	3549.79	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	17.76	29 / 29
muscle	100%	5769.43	803 / 803	0%	0	0 / 0
spleen	100%	2807.94	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	23.61	45 / 45
ureter	0%	0	0 / 0	100%	10.57	1 / 1
peripheral blood	97%	2645.38	901 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	96%	15.42	77 / 80
heart	96%	1850.18	824 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006325	Biological process	chromatin organization
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0044545	Cellular component	NSL complex
GO_0071339	Cellular component	MLL1 complex
GO_0000123	Cellular component	histone acetyltransferase complex
GO_0031965	Cellular component	nuclear membrane
GO_0003677	Molecular function	DNA binding
GO_0005515	Molecular function	protein binding
GO_0046872	Molecular function	metal ion binding

IV. Literature review

[source]

Gene name	PHF20
Protein name	PHD finger protein 20 PHD finger protein 20 (Glioma-expressed antigen 2) (Hepatocellular carcinoma-associated antigen 58) (Novel zinc finger protein) (Transcription factor TZP)
Synonyms	NZF HCA58 TZP GLEA2 C20orf104
Description	FUNCTION: Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage. .
Accessions	ENST00000374000.8 Q5JWZ0 B0QYY0 ENST00000449988.1 ENST00000374012.8 [Q9BVI0-1] Q9BVI0 ENST00000339089.10 F8WCQ1 B0QZ19 ENST00000420233.1 ENST00000452270.5 Q5JXL1

PHF20 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review