MTPN | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	35 studies	41% ± 15%	Explore
endothelial cell	31 studies	28% ± 10%	Explore
macrophage	30 studies	31% ± 9%	Explore
natural killer cell	28 studies	31% ± 11%	Explore
conventional dendritic cell	28 studies	42% ± 17%	Explore
classical monocyte	24 studies	45% ± 15%	Explore
non-classical monocyte	23 studies	60% ± 20%	Explore
memory B cell	20 studies	42% ± 12%	Explore
naive B cell	20 studies	42% ± 12%	Explore
CD8-positive, alpha-beta T cell	20 studies	26% ± 9%	Explore
monocyte	19 studies	41% ± 14%	Explore
fibroblast	19 studies	27% ± 9%	Explore
plasmacytoid dendritic cell	19 studies	43% ± 15%	Explore
CD4-positive, alpha-beta T cell	18 studies	26% ± 9%	Explore
gamma-delta T cell	16 studies	30% ± 12%	Explore
regulatory T cell	16 studies	25% ± 5%	Explore
T cell	15 studies	23% ± 7%	Explore
dendritic cell	15 studies	43% ± 26%	Explore
mast cell	15 studies	28% ± 12%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	34% ± 9%	Explore
pericyte	12 studies	22% ± 7%	Explore
smooth muscle cell	12 studies	22% ± 6%	Explore
mature NK T cell	12 studies	28% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	28% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	30% ± 9%	Explore
mucosal invariant T cell	11 studies	28% ± 6%	Explore
myeloid cell	11 studies	37% ± 18%	Explore
epithelial cell	11 studies	35% ± 20%	Explore
platelet	10 studies	56% ± 16%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	25% ± 5%	Explore
endothelial cell of lymphatic vessel	9 studies	24% ± 9%	Explore
basal cell	9 studies	27% ± 14%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	26% ± 8%	Explore
endothelial cell of vascular tree	9 studies	26% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	27% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	33% ± 9%	Explore
endothelial cell of artery	8 studies	23% ± 6%	Explore
glutamatergic neuron	8 studies	34% ± 16%	Explore
hematopoietic stem cell	8 studies	49% ± 14%	Explore
ciliated cell	8 studies	34% ± 14%	Explore
alveolar macrophage	7 studies	46% ± 14%	Explore
plasmablast	7 studies	38% ± 20%	Explore
secretory cell	7 studies	28% ± 13%	Explore
capillary endothelial cell	7 studies	23% ± 7%	Explore
abnormal cell	7 studies	26% ± 9%	Explore
myofibroblast cell	7 studies	22% ± 6%	Explore
precursor B cell	7 studies	48% ± 11%	Explore
hematopoietic precursor cell	6 studies	45% ± 19%	Explore
plasma cell	6 studies	28% ± 11%	Explore
neutrophil	6 studies	26% ± 4%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	31% ± 9%	Explore
mononuclear phagocyte	6 studies	36% ± 12%	Explore
innate lymphoid cell	6 studies	25% ± 5%	Explore
immature B cell	6 studies	52% ± 10%	Explore
astrocyte	6 studies	29% ± 6%	Explore
vein endothelial cell	6 studies	25% ± 9%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	29% ± 9%	Explore
connective tissue cell	6 studies	29% ± 8%	Explore
leukocyte	5 studies	31% ± 8%	Explore
neuron	5 studies	34% ± 9%	Explore
pro-B cell	5 studies	34% ± 12%	Explore
microglial cell	5 studies	26% ± 7%	Explore
T follicular helper cell	5 studies	21% ± 3%	Explore
squamous epithelial cell	4 studies	37% ± 20%	Explore
exhausted T cell	4 studies	30% ± 13%	Explore
megakaryocyte	4 studies	59% ± 26%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	26% ± 6%	Explore
intermediate monocyte	4 studies	55% ± 24%	Explore
erythrocyte	4 studies	28% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	26% ± 7%	Explore
GABAergic neuron	4 studies	33% ± 14%	Explore
respiratory goblet cell	3 studies	21% ± 4%	Explore
lymphocyte	3 studies	38% ± 11%	Explore
retinal cone cell	3 studies	28% ± 7%	Explore
tissue-resident macrophage	3 studies	21% ± 3%	Explore
Mueller cell	3 studies	24% ± 7%	Explore
germinal center B cell	3 studies	34% ± 8%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	68% ± 0%	Explore
goblet cell	3 studies	19% ± 2%	Explore
group 3 innate lymphoid cell	3 studies	33% ± 14%	Explore
T-helper 17 cell	3 studies	21% ± 3%	Explore
T-helper 1 cell	3 studies	21% ± 6%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	26% ± 3%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	25% ± 5%	Explore
double negative thymocyte	3 studies	41% ± 8%	Explore
interneuron	3 studies	35% ± 18%	Explore
oligodendrocyte	3 studies	20% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	16 studies	40% ± 13%	Explore
lung	13 studies	27% ± 13%	Explore
brain	7 studies	27% ± 10%	Explore
intestine	5 studies	22% ± 7%	Explore
kidney	5 studies	20% ± 5%	Explore
lymph node	5 studies	24% ± 6%	Explore
bone marrow	4 studies	37% ± 12%	Explore
uterus	4 studies	34% ± 15%	Explore
liver	4 studies	30% ± 12%	Explore
eye	3 studies	24% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
uterus	100%	6160.78	170 / 170	100%	160.18	459 / 459
esophagus	100%	8993.80	1444 / 1445	100%	158.12	183 / 183
brain	100%	8602.78	2638 / 2642	100%	289.99	705 / 705
breast	100%	5863.20	459 / 459	100%	187.95	1116 / 1118
ovary	100%	5014.49	180 / 180	100%	129.30	429 / 430
lung	100%	6908.39	577 / 578	100%	180.98	1152 / 1155
thymus	100%	6414.61	653 / 653	99%	161.88	601 / 605
intestine	100%	5446.53	966 / 966	99%	143.20	523 / 527
prostate	100%	5240.34	244 / 245	100%	123.95	500 / 502
bladder	100%	6342.95	21 / 21	99%	150.12	499 / 504
kidney	100%	4630.43	89 / 89	98%	166.48	885 / 901
stomach	98%	3499.41	353 / 359	100%	131.48	285 / 286
skin	100%	8025.39	1805 / 1809	98%	278.01	463 / 472
adrenal gland	100%	5359.55	258 / 258	97%	134.49	224 / 230
liver	91%	2116.65	205 / 226	87%	61.79	354 / 406
pancreas	70%	1367.78	228 / 328	99%	135.51	176 / 178
adipose	100%	6789.70	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	188.42	29 / 29
spleen	100%	6626.80	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	155.18	45 / 45
ureter	0%	0	0 / 0	100%	49.73	1 / 1
blood vessel	100%	6975.42	1334 / 1335	0%	0	0 / 0
muscle	99%	4055.70	796 / 803	0%	0	0 / 0
peripheral blood	99%	9925.74	916 / 929	0%	0	0 / 0
heart	95%	4588.73	819 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	94%	105.48	75 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_2000812	Biological process	regulation of barbed-end actin filament capping
GO_0071260	Biological process	cellular response to mechanical stimulus
GO_0051247	Biological process	positive regulation of protein metabolic process
GO_0030307	Biological process	positive regulation of cell growth
GO_0010613	Biological process	positive regulation of cardiac muscle hypertrophy
GO_0010557	Biological process	positive regulation of macromolecule biosynthetic process
GO_0043403	Biological process	skeletal muscle tissue regeneration
GO_0051146	Biological process	striated muscle cell differentiation
GO_0006417	Biological process	regulation of translation
GO_0051092	Biological process	positive regulation of NF-kappaB transcription factor activity
GO_0030182	Biological process	neuron differentiation
GO_0006584	Biological process	catecholamine metabolic process
GO_0008361	Biological process	regulation of cell size
GO_0021707	Biological process	cerebellar granule cell differentiation
GO_0016202	Biological process	regulation of striated muscle tissue development
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0008290	Cellular component	F-actin capping protein complex
GO_0030424	Cellular component	axon
GO_0005634	Cellular component	nucleus
GO_0043565	Molecular function	sequence-specific DNA binding

IV. Literature review

[source]

Gene name	MTPN
Protein name	Myotrophin Myotrophin (Protein V-1) Myotrophin (V-1 protein) (cDNA FLJ31663 fis, clone NT2RI2004504, highly similar to MYOTROPHIN)
Synonyms	DKFZp761E1322 tcag7.994 hCG_16971
Description	FUNCTION: Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. .
Accessions	Q69YG1 P58546 ENST00000435723.1 ENST00000393085.4 C9JL85

MTPN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review