MORF4L2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0006281Biological processDNA repair
GO_0042981Biological processregulation of apoptotic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_2000779Biological processregulation of double-strand break repair
GO_0051726Biological processregulation of cell cycle
GO_1905168Biological processpositive regulation of double-strand break repair via homologous recombination
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005886Cellular componentplasma membrane
GO_0000786Cellular componentnucleosome
GO_0035267Cellular componentNuA4 histone acetyltransferase complex
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMORF4L2
Protein nameMortality factor 4-like protein 2 (MORF-related gene X protein) (Protein MSL3-2) (Transcription factor-like protein MRGX)
Mortality factor 4-like protein 2
Mortality factor 4 like 2
SynonymsKIAA0026
MRGX
DescriptionFUNCTION: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also a component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones.

FUNCTION: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also a component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones. .

FUNCTION: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also a component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones. .

AccessionsENST00000441076.7
ENST00000360458.5
ENST00000451301.5
Q5JXX1
ENST00000442614.5
ENST00000433176.6
Q15014
ENST00000418819.5
ENST00000434230.5
ENST00000422355.5
Q5JXX2
Q5JXX6